Sharing knowledge about psychedelics (3)

Sharing knowledge about psychedelics (3)

Princesa Sophia



PAGES:

1, 2;





CGPT (maybe 3.5):

The concept of a "fatal dose" can vary significantly based on individual factors such as body weight, tolerance, and overall health. However, here are some general insights regarding the substances you mentioned:

  1. THC (Tetrahydrocannabinol): There is no established lethal dose of THC. Studies suggest that the median lethal dose (LD50) is extremely high, estimated to be around 1,000 mg/kg in rats, which would translate to an impractically large amount for humans.
  2. CBD (Cannabidiol): Similar to THC, there is no known fatal dose of CBD. It is generally considered safe, with high doses (up to 1,500 mg per day) being well tolerated in humans without serious adverse effects.
  3. Cannabis (overall): Cannabis as a whole has a very high LD50, and there are no documented cases of fatal overdose from cannabis alone. The risk of fatality is more associated with other factors, such as accidents or underlying health conditions.
  4. Psilocybin (found in magic mushrooms): The estimated LD50 for psilocybin is around 280 mg/kg in rats, but there are no confirmed human fatalities from psilocybin overdose. The effects are primarily psychological rather than physical.
  5. LSD (Lysergic acid diethylamide): The estimated LD50 for LSD is around 200 mg/kg in rats, but there are very few documented cases of fatal overdose in humans. Most risks associated with LSD are psychological.
  6. Mescaline: The LD50 for mescaline is estimated to be around 200 mg/kg in rats, but like other psychedelics, there are no confirmed cases of fatal overdose in humans.
  7. DMT (Dimethyltryptamine): There is limited data on the LD50 for DMT, but it is considered to have a low toxicity profile. There are no known cases of fatal overdose from DMT.

It's important to note that while these substances may not have a well-defined fatal dose, they can still pose risks, especially in combination with other substances or in individuals with certain health conditions. Always approach the use of any psychoactive substance with caution and awareness of the potential risks.



ADDICTION AND OVERALL DANGER:


  • NOTE: For those who don't know, there is a difference between someone becoming addicted psychologically and simple "thrive in wanting it", than addictions like alcoholism, which is physical, and by stopping to drink, may lead to physical problems, like, delirium-tremens or even death.





I don't like this graph that much, because i think it depends on the type of users, set of using, the amount you can afford and etc. For example, in no way Ecstasy gives less addiction than LSD, this makes no sense AT ALL, i heard about people that used MDMA everyday, but not people that use LSD everyday (only micro-doses, which are barely anything). Maybe it is talking about physical addiction, which also does not make sense, since LSD, as far as i know, does not gives physical addiction.


The same way i see cannabis in this list, in no way cannabis is more dangerous than MDMA in my view. I wouldn't also say it is less dangerous, but as much. But i believe that weed is so, but so popular (some people only use weed as a drug beyond alcohol and tobacco), that you may gather way more data of stupid people being stupid under weed effect.



Psychedelics are barely addictive, and not physically addictive, only psychologically. Most people that use psychedelics normally refrain repeated uses to at least a week or even months. I myself had a moment where i was rushing to discover the spiritual and i was using once per two weeks, but sometimes once per week, and now i see i was using too much and building tolerance. And so, in most of my life i began to limit myself to use only after one month. And recently, i keep months without using strong psychedelics (more because money, because i think once a month is fine, depends on the dose).


I may warn you that weed may be more addictive to vulnerable individuals. But even in the time i used to smoke weed everyday, i would not consider myself addicted, because when i lacked money or weed, i would not be crying or sell stuff to buy weed. In fact, never ever in my life i heard about people selling stuff to buy weed, but there is lot of cases of people selling random useful objects, emotional memorabilia, jewels and etc to buy crack-cocaine.


In this case, i would in fact blame the vulnerability of the person to get addicted to weed, because this person is very likely prone to addiction in any other thing if that is the case. People can be addicted to anything, chocolate, food, gym, work and etc... So, if we measure how people normally get addicted to stuff (mostly because dopamine reward system) and that we don't simple consider those stuff addictive, we can simple scratch out the idea that weed is addictive, and simple say that it is just "more addictive than LSD"; and most because you can smoke very low doses of weed and it is easy and simple to smoke everyday and the effects don't last as long as orally used psychedelics. Or better, the low effort and the high return from weed makes it simple to "just use it", and this may make people simple "smoke everyday", and then may make some vulnerable people to lose their ability to deal with lack of weed.


~*~


Another thing i heard is the "can give psychosis" argument.

As far as i know, the studies are not exactly conclusive, and it is more like a study made on correlation than on the bio-chemical mechanisms of it.

I made an elaborated article about it where i try to be unbiased and scientific as possible (the article is mine, even thought AI edited to remove colloquial expressiveness):

https://telegra.ph/Beyond-Fear-Cannabis-Psychedelics-Psychosis-and-the-Endocannabinoid-System-09-11



Those people would end up having psychosis one moment or another anyway, they were already psychotic and they don't knew it, and so, of course an increase in brain activity would also increase the part of the brain that deals with psychosis. My theory is simple that the person perceive what they already had a long ago, but now he could see clearly and can't ignore anymore. The psychosis is not fruit of psychedelics, but attenuated by psychedelics.


And so, even if i have psychosis myself and i use it anyway, i think one should be VERY aware that in doing it may reveal a latent psychosis in someone, or that one that knowingly have psychosis should accept that this one have risks by increasing this mental condition. In short, if you are part of Cluster A, you should plan yourself better before using such substances, to everyone i say to "start low", but for Cluster A people i say in especial.


~*~


Numerous studies shows that use of cannabis when teen is not proper. Even if i started using cannabis when i was 15 (iirc), and i don't think i have any problem because of it. I still think we should trust those studies, more because a teenager brain is in development, and i think lot of things may mess up with it.


However, in this case, i see more teenagers abusing alcohol (including me, that think my dependency is fruit of the fact i started drinking when i was 13) and that this is way more harmful (and so, weed made me reduce and hate alcohol when i was smoking it more when i was 16; while, before, i used to "praise" alcohol). And so, this is not a good excuse. The same for tobacco too.


Especially if this argument is used in terms of prohibition, because, a dealer wont ask your ID to sell weed, and so, it is simple easier to avoid teenagers to have contact with weed by legalizing it.

But, once again, i DO NOT recommend the use by minors, even i did that myself and i was not harmed.




PHYSICAL:


MENTAL:


SPIRITUAL:






RECIPES AND DOSES:


!!! VERY IMPORTANT NOTES, DO NOT SKIP THIS LIST !!!

  • Every person have different metabolism, sensibility, mind (i'm schizoid, so i'm more sensible than normal people) and etc. The Height/Weight ratio is very important, that measure is used in pharmacy specifically for being an accurate way to measure a proper dose (i'm not a pharmacist to affirm that).
  • Read: https://en.wikipedia.org/wiki/Dose_(biochemistry)
  • https://en.wikipedia.org/wiki/Toxicology
  • https://en.wikipedia.org/wiki/EC50 // Half maximal effective concentration.
  • https://en.wikipedia.org/wiki/Agonist // There is a list of different agonist types, and so you can use as reference if a substance is partially or fully agonist, which them may lead to normal or stronger potency.
  • https://en.wikipedia.org/wiki/Receptor_antagonist
  • Things like SSRI can reduce a lot the effects, at a point of some people saying it nullifies a trip. Anecdotal, but i once heard in a group a guy that took 3g of a strong mushroom and said he felt nothing, when asked if he uses something, he admitted to use anti-depressants, and then by doing research, the medicine he used had SSRI. It is also dangerous to use in mixture with certain substances, as it can lead to serotonin syndrome.
  • MAOI is used in Ayahuasca, DMT (derived and alike substances) is not easily absorbed by the body, you need a lot of ayahuasca to feel the effect if it was Ayahuasca alone. With MAOI, in lay terms, opens your body to accept chemicals of certain category, and that is why Ayahuasca makes effect. However, because of that, some other substances may lead to bad effects, even some that may be fatal, especially to vulnerable people. Some food you eat may give you headaches, and some other stronger chemicals you use may lead to more potent side-effects that can lead to death! That is why, to use Ayahuasca, is recommended to fast for at least 12h.
  • MAOI is also a type of antidepressant, and you may need to check if some medicines you use may contain it; however, it is the opposite of SSRI, it may INTENSIFY the effects. Passion fruit contain small doses of MAOI (depends on the sub-specie), be aware of that (both in terms of wanting to increase the strength of a trip, or to avoid an increase in case you ate the fruit without being aware of it). MAOI can be used to intensify the trips of numerous substances, you may use it in a proper way if you are an experienced psychonaut. Wachuma have Tyramine and may not be good to mix up. I don't recommend those "hacks" to noobs, neither i recommend to noobs any type of weird mixture.
  • Wiki: "Certain combinations can cause lethal reactions; common examples include SSRIs, tricyclics, MDMA, meperidine, tramadol, and dextromethorphan, whereas combinations with LSD, psilocybin, or DMT appear to be relatively safe. Drugs that affect the release or reuptake of epinephrine, norepinephrine, serotonin or dopamine typically need to be administered at lower doses due to the resulting potentiated and prolonged effect. MAOIs also interact with tobacco-containing products (e.g. cigarettes) and may potentiate the effects of certain compounds in tobacco. This may be reflected in the difficulty of smoking cessation, as tobacco contains naturally occurring MAOI compounds in addition to the nicotine".



LSD BASED STRENGTH CONVERSION:

Totally scientific anecdotal stats based on my experiences, hahaha. And then, of course, this can only list plants i used.

Since LSD have a mathematical precision by being an isolated substance, i think it is a good reference to interpret how strong is the effects of other psychedelics.

Take in mind that plants (or mushrooms) can vary in the amount of the active ingredient (mescaline, THC, DMT and etc), some a lot and some few.


  • 25g of dried Wachuma skin = 75 to 125ug (Wachuma varies a lot in how much mescaline it contains: "from 0.053% up to 4.7% of dry cactus weight" [1]; it might be a surprise or a boring day), Wachuma is one of the psychedelics i most used, it is cheap and easy to prepare, after mushroom and LSD, it is the easiest to use and the taste is pretty tolerable; ratio: 3 to 5 ug/g.
  • 2g of mushroom (i only used the Cambodian variation) = 67 to 75ug, but it can vary, i have not used much mushroom to be honest, but i heard about trips of 2g that was more intense than one expected; ratio: 33.5 to 37.5 ug/g.
  • 7 Argyreia seeds = 75 to 100ug, but Argyreias are normally sold to plant and not to use, and they don't have proper quality system and so i had seeds that only gave me nausea and no trip. I used 7 seeds multiple times in my life, so i have lot of experience to affirm this comparison; ratio: 10.71 to 14.2857 ug/seed.
  • 1 medium weed joint = 67ug, this may be a polemic one, but, for real, if you keep long time without weed and smoke a medium sized one, like about less than 1/2 of a industrial tobacco cigarette, it would be like 67ug of LSD for at least from the 5 minutes to 12 minutes mark.

I once averaged, and i think (no accuracy) that my medium sized joints are around 0.33 grams, so, 0.33 grams would be like 67ug, at least below 15 minutes mark; ratio: 203 ug/g, which makes sense, if you smoke a very good 1 gram of weed in a joint, i think the peak might be around the 203ug indeed, but it also looks a little exaggerated, i don't know, let's keep that way for now. I have never eaten weed, so i don't know how to compare in terms of eating it.

  • 1/3 of my one-hitter of Changa = 300ug to 400ug. Take in mind, it depends of the balance and concentration from the one that makes it. And, yes, it is that strong in the first few minutes, just when you are in the process of inhaling the first hit, you already see kaleidoscopes pulsing in your open-eyes-hallucination. Since i'm totally unsure of how much grams my one-hitter weights, i'm going to guess that a full well compressed (but that you can still easily smoke) of my pipe is about 0.4g of weed, and so, 0.1333g would be about the amount to compare, i may have not even fully smoked the 1/3; ratio: 2250 to 3000 ug/g.
  • Salvia, sadly i could never measure it until it got prohibited in my country, but i would say that very likely 0.5g can be alike 500ug, however, Salvia effect is very different, and you can't use small doses, there is a threshold dose which is already too strong. It also acts in another receptor, and it is more "delirant-like" than "psychedelic", and so, some things that happens in the Salvia would be things i heard when people had overdoses like above 1000ug, so it would be like 1000ug/g, but with somes effects you would expect from 2000ug (what?! Well, this number is just a number, maybe at this point any measure is useless).
  • Ayahuasca is made in temples here, it is prohibited outside of it, even if some people get it or use legal analogues (such stupid laws, uh?!) that are as strong and equal in effect (most used here: Chaliponga + Syrian Rue). Since these brews are done in masses for people, you can never know the concentration and effects, and the plant also varies in concentration of the active principles. I had places i took 4 cups to have something like 67ug, and places i took 2 small coffee cups and had like 75ug.

The last temple i went that i went the most, 3 cups would be like 75ug to 100ug, i would drink mostly 4 cups at the temple, but sometimes 3 cups, by this measure, the place i went would have 50 to 67ug at 2 cups, which i would say is very accurate, and people that don't smoke weed and have Ayahuasca moments only once per one or two months, would normally stop at 2 cups and feel well about it, which is alike what some not-so-drugged-friends i had would feel at 50ug. The cup were those of around 150 to 175ml, and so, the ratio is: 0.1667 to 0.222ug/ml or 0.142857 to 0.190476 ug/ml.



DOSES:

The content can be approximated to:

g * n% / 100.



List works like:


~*~ ~*~ ~*~ ~*~ ~*~ ~*~ ~*~

  • Commentary.

n% of active ingredient per gram, or the number of instances of a substance.

Name of the active ingredient.


Spiritual = dose: approximation of the amount of active ingredient.

Recreational...

Therapeutic (micro-dose)...

~*~ ~*~ ~*~ ~*~ ~*~ ~*~ ~*~



Argyreia Nervosa:

  • Wiki: "LSA weight ranging between exactly similar looking seeds from 3 μg to 34 μg (avg 17 μg). However, in its effects, LSA is about one tenth as potent as its cousin LSD, making a threshold dose level for LSA (D-Lysergic Acid Amide) about 500 μg".
  • This seems strange, since i think 7 seeds are alike 75 to 100ug, but that would mean it is (in terms of LSA), 21 to 238ug, which should be in average 12ug of LSD. No, in no way this is like this, 12ug of LSD barely makes any effect, in fact, i would say it makes no effect.
  • This is also pointed in the wiki: "The psychoactive effects of the seeds may therefore be due to other alkaloids present in them and the safe and effective dose may be difficult to predict".
  • The seeds are almost the size of a pea.
  • By my calculation, if it was only LSA that made effect, then it is 1.19 times weaker than LSD.

17ug per seed (however, it is unlikely that this is the sole case for trip) and 0.136% of the seed weight (converting: (17/0.0136)/1000 = 1.25mg per seed).

LSA (but very likely other ones too).


Spiritual = 7 seeds (8.75mg): 119ug.

Recreational = 5 seeds (6.25mg): 85ug.

Therapeutic = 3 seeds (3.75mg): 51ug.



LSD:

  • ...

Isolated substance, no specific amount per bottler.

LSD.


Spiritual = 75 to 100ug.

Recreational = 50 to 67ug.

Therapeutic = 33 to 49ug.



Psilocybe mushroom:

Cambodian:

0.45%.

Psilocybin.


Spiritual = 2.75g: 0.12375g.

Recreational = 1.5g: 0.0675g.

Therapeutic = 0.75g: 0.03375g.



Wachuma:

  • This is based on dry cactus skin, not cactus powder or raw cactus. Check photo below:
  • Like said, Wachuma may have 0.053% up to 4.7% of dry cactus weight of mescaline. So we can average that to:

2.3235%.

Mescaline.


Spiritual = 25g: 0.580875g of mescaline.

Recreational = 12g: 0.27882g.

Therapeutic (micro-dose) = 8g: 0.18588g.





RECIPES:

1) Very-low nausea Argyreia lemon extract;

2) Basic Wachuma tea;

3) Chaliponga + Syrian rue Ayahuasca analogue;



1) Very-low nausea Argyreia lemon extract:


  • Get 7 seeds of argyreia (or less, but that is my ideal dose).
  • Crush it inside a cup (or somewhere else). You may also bite and spit inside a cup (if that is not too gross for you and it is your cup anyway).
  • Then press a lemon until the juice gets as height like 4/3 to 2 times above the height of the seeds.
  • Leave it inside a dark place for 12h.


  • NOTE: LSA is sensible to light and heat. So, i normally cover the top of the cup with something (plastic, paper with a weight above it and etc) and put it hidden in a dark place (inside a box inside my wardrobe; inside a plastic deep inside the wardrobe).


  • Final:

Should leave it like that for at least 12h, not sure how long is the ideal, but i have let for 24h too. The ideal is to do it the day before, sleep, and wake up with it ready to be used. If one wakes up from 8 - 12h, then by sleeping, eating a breakfast, doing something else, then it would be about 12 - 16h after you wake up and the seeds would be ready to be used.


Then: just drink it all, i think there is LSA left in the pieces of seed, so i drink it with the seeds too.

Have fun and a nice trip!

It is not nausea-proof, but it does remove all the ache of the raw Argyreia.

It is now only the nausea without pain, and like 1/4 to 1/3 of what would be with Raw Argyreia. It may annoy a little, but not in a way that will deflect you from having such trip. The cost-benefit of the trip vs nausea is worth, the effects distract you from it and i could even say the nausea is negligible, and like i said previously, i used lot of Argyreia in my life, so if it is not worth, i would have not done it so many times while i already knew about Wachuma.



2) Basic Wachuma tea:


  • Get 25g of dry Wachuma skins.
  • Throw in a milk pan (can be any pan, but that is easier to fill with water and heat it), not sure if the right word, in portuguese we call "leiteira":


  • Fill the double or a little more of water than you pretend to drink, let all cactus under the water (that i why i recommend the pan above).
  • Squish a whole small lime on the water, the acid of it will help extract more mescaline.
  • Cook until you reduce to like 2/3 of the water, then put this brew somewhere else. Keep the cactus inside the pan.
  • Fill with the same amount (or a little less) of water and reduce to 2/3 again. Do this one more time (three extractions), two more if you want more extraction (not sure of science of it). I add lemon only at the first extraction, not sure if adding more helps, i'm not a chemistry person.
  • Throw the cactus pieces away, put all the saved brew again on the pan and reduce until you think it is proper to drink it easily. I think the ideal is 2/5 of a mug (the average mug in my country is about 300ml), so you can drink in a single "shot". The more you reduce, the stronger the taste is, the less you reduce, the more you have to drink.


Some people said to me long ago (but i can't find anything online to confirm) that you should heat at medium-high to not destroy some mescaline. I'm not sure if that is true. I used to do like this, but i have also once started making it at full heat and it worked.

At the time i started using psychedelics, there had extremely few information online. Erowid was basically the only place to know about it.


It taste like strong passed Chimarrão (Yerba Mate, for spanish speaking latinos), it is easy to drink, but some people may be more fussy towards it. I may be biased, since i drink sugar-less strong black coffee everyday, but some people can't drink coffee without sugar. For me, Wachuma is super easy and fine to drink, Ayahuasca is three times worse in my opinion (pretty specific, but accurate). That is why i say that after LSD and mushrooms, Wachuma is the easiest psychedelic to use: fast to make, not that bad, easy to drink.


There is people that complain about the taste, they are probably literally gay or a girl. I literally only knew about girls complaining about taste, since girls tends to like sweet stuff. I mean, it does not taste good, of course, and it depends on the dose, concentration and etc, if you keep drinking with small sip by small sip, this would rapidly become nauseating and then i would agree you can complain about the taste. That is why i recommend 2/5 of a mug.


You don't need to drink it at once, you can drink, wait a little, drink more. I think this is a good approach, since Wachuma can vary a lot in the amount of mescaline it have. And i think my Mega Wachuma day, the cactus was strong in special, since my friends that took 16g were in a strong trip.



3) Chaliponga + Syrian rue Ayahuasca analogue:


W.I.P.





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