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The most popular drug of abuse in Egypt is the prescription painkiller tramadol. With an illegal drug trade reaching billion Egyptian pounds in , Egypt now plan to open an addiction treatment centre in each governorate with free treatment for patients. If such a huge number of them are addicted, this means the future of Egypt is in danger. This is why the country should have serious programs and plans to fight this threat. Randox Toxicology produce an accurate drug profile to ensure confidence in results. March 6, Request Demo.

Egypt fights a losing battle against drugs

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Drug dependence is a chronic brain disease characterized by craving and recurrent episodes of relapse. Tramadol HCl is a promising agent for withdrawal symptoms management, considering its relatively low abuse potential and safety. Oral administration, however, is not preferred in abstinence maintenance programs. Introducing an implantable, long-lasting formula is suggested to help outpatient abstinence programs achieve higher rates of treatment continuation. Tramadol implants T and T were prepared on polycaprolactone polymer ribbons by the wet method. Implants were surgically implanted in the back skin of rats. After 14 days, the CPP score was recorded. Elevated plus maze and open field tests were performed for anxiety-related symptoms. Striata were analyzed for neurochemical changes reflected in dopamine, 3,4-dihydroxyphenyl acetic acid, gamma-aminobutyric acid, and serotonin levels. Brain oxidative changes including glutathione and lipid peroxides were assessed. The tramadol implants T and T reduced heroin CPP and limited naloxone-induced withdrawal symptoms. The striata showed increased levels of 3,4-dihydroxyphenyl acetic acid, and serotonin and decreased levels of gamma-aminobutyric acid and dopamine after heroin withdrawal induction, which were reversed after implanting T and T Implants restore the brain oxidative state. Nonsignificant low naloxone-induced withdrawal score after the implant was used in naive subjects indicating low abuse potential of the implants. The presented tramadol implants were effective at diminishing heroin CPP and withdrawal in rats, suggesting further investigations for application in the management of opioid withdrawal. All rights reserved. Abstract Drug dependence is a chronic brain disease characterized by craving and recurrent episodes of relapse.

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