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Chronic thioridazine treatment in animals has been reported to produce less dopaminergic supersensitivity than other neuroleptics. This difference may be due to the potent calcium channel inhibitory effect of thioridazine. To test this hypothesis Swiss-Webster mice were treated chronically 28 d with calcium channel inhibitors CCI's — diltiazem, nifedipine or verapamil — with or without haloperidol. Following three days of drug withdrawal, mice were tested for amphetamine-induced locomotion and apomorphine-induced cage climbing. Co-administration of diltiazem or verapamil but not nifedipine prevented the development of haloperidol-induced behavioral supersensitivity to apomorphine. Co-administration of CCI's with haloperidol did not affect the development of amphetamine supersensitivity. These data support the hypothesis that coadministration of haloperidol and a CCI verapamil or diltiazem, but not nifedipine would mimic the effects of thioridazine treatment alone. This is a preview of subscription content, log in via an institution to check access. Rent this article via DeepDyve. Institutional subscriptions. Anath J Current psychopathological theories of tardive dyskinesia and their implications for future research. Neuropsychobiology 8: — PubMed Google Scholar. Axelsson J, Thesleff S A study of supersensitivity in denervated mammalian skeletal muscle. J Physiol London — Google Scholar. Biol Psychiatry — Neurosci Lett — Article PubMed Google Scholar. Biol Psych — Psychopharmacology — Life Sci — Goldstein JA Calcium and neurotransmission. Biol Psychiatry Letter Am J Psychiatry — Grebb JA Nifedipin and flunarizine block amphetamine-induced behavioral stimulation in mice. Pharmacol Biochem Behav — Middlemiss DN, Spedding M A functional correlate for a dihydropyridine binding site in the rat brain. Nature 94— Neuropharmacol — Article Google Scholar. Science — Protais P, Costentin J, Schwartz JC Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum. Psychopharmacology 1—6. Robertson A, MacDonald C Atypical neuroleptics clozapine and thioridazine enhance amphetamine-induced stereotypy. Pharmacol Biochem Behav 97— Starke K, Spath L, Wichman T Effects of verapamil, diltiazem and ryosidine on the release of dopamine and acetylcholine in rabbit caudate nucleus slices. Naunyn-Schmiedebergs Arch Pharmacol — Thorgeirsson G, Rudolph SA Diltiazem-like effect of thioridazine on the dihydropyridine binding sites of the calcium channel of rat myocardial membranes. Biochem Biophys Res Commun — Turner TS, Goldin SM Calcium channels in rat brain synaptosomes: identification and pharmacological characterization. J Neurosci 5: — J Pharmacol Exp Ther 88— Westlin WF Tardive dyskineasia and thioridazine Letter. Arch Gen Psychiatry Download references. You can also search for this author in PubMed Google Scholar. Reprints and permissions. Grebb, J. Diltiazem or verapamil prevents haloperidol-induced apomorphine supersensitivity in mice. Neural Transmission 68 , — Download citation. Received : 28 March Revised : 02 June Issue Date : September Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Home Journal of Neural Transmission Article Diltiazem or verapamil prevents haloperidol-induced apomorphine supersensitivity in mice Original Papers Published: September Volume 68 , pages —, Cite this article. Journal of Neural Transmission Aims and scope Submit manuscript. Summary Chronic thioridazine treatment in animals has been reported to produce less dopaminergic supersensitivity than other neuroleptics. Access this article Log in via an institution. Interactions of calmodulin kinase II with the dopamine transporter facilitate cocaine-induced enhancement of evoked dopamine release Article Open access 13 June Differential effects of acute and chronic antagonist and an irreversible antagonist treatment on cocaine self-administration behavior in rats Article Open access 24 May References Anath J Current psychopathological theories of tardive dyskinesia and their implications for future research. Author information Author notes J. Shelton Authors J. Grebb View author publications. View author publications. Rights and permissions Reprints and permissions. About this article Cite this article Grebb, J. Copy to clipboard. Search Search by keyword or author Search. Navigation Find a journal Publish with us Track your research.

Triesenberg buy cocaine