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Chronic thioridazine treatment in animals has been reported to produce less dopaminergic supersensitivity than other neuroleptics. This difference may be due to the potent calcium channel inhibitory effect of thioridazine. To test this hypothesis Swiss-Webster mice were treated chronically 28 d with calcium channel inhibitors CCI's — diltiazem, nifedipine or verapamil — with or without haloperidol. Following three days of drug withdrawal, mice were tested for amphetamine-induced locomotion and apomorphine-induced cage climbing. Co-administration of diltiazem or verapamil but not nifedipine prevented the development of haloperidol-induced behavioral supersensitivity to apomorphine. Co-administration of CCI's with haloperidol did not affect the development of amphetamine supersensitivity. These data support the hypothesis that coadministration of haloperidol and a CCI verapamil or diltiazem, but not nifedipine would mimic the effects of thioridazine treatment alone. This is a preview of subscription content, log in via an institution to check access. Rent this article via DeepDyve. Institutional subscriptions. Anath J Current psychopathological theories of tardive dyskinesia and their implications for future research. Neuropsychobiology 8: — PubMed Google Scholar. Axelsson J, Thesleff S A study of supersensitivity in denervated mammalian skeletal muscle. J Physiol London — Google Scholar. Biol Psychiatry — Neurosci Lett — Article PubMed Google Scholar. Biol Psych — Psychopharmacology — Life Sci — Goldstein JA Calcium and neurotransmission. Biol Psychiatry Letter Am J Psychiatry — Grebb JA Nifedipin and flunarizine block amphetamine-induced behavioral stimulation in mice. Pharmacol Biochem Behav — Middlemiss DN, Spedding M A functional correlate for a dihydropyridine binding site in the rat brain. Nature 94— Neuropharmacol — Article Google Scholar. Science — Protais P, Costentin J, Schwartz JC Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum. Psychopharmacology 1—6. Robertson A, MacDonald C Atypical neuroleptics clozapine and thioridazine enhance amphetamine-induced stereotypy. Pharmacol Biochem Behav 97— Starke K, Spath L, Wichman T Effects of verapamil, diltiazem and ryosidine on the release of dopamine and acetylcholine in rabbit caudate nucleus slices. Naunyn-Schmiedebergs Arch Pharmacol — Thorgeirsson G, Rudolph SA Diltiazem-like effect of thioridazine on the dihydropyridine binding sites of the calcium channel of rat myocardial membranes. Biochem Biophys Res Commun — Turner TS, Goldin SM Calcium channels in rat brain synaptosomes: identification and pharmacological characterization. J Neurosci 5: — J Pharmacol Exp Ther 88— Westlin WF Tardive dyskineasia and thioridazine Letter. Arch Gen Psychiatry Download references. You can also search for this author in PubMed Google Scholar. Reprints and permissions. Grebb, J. Diltiazem or verapamil prevents haloperidol-induced apomorphine supersensitivity in mice. Neural Transmission 68 , — Download citation. Received : 28 March Revised : 02 June Issue Date : September Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Home Journal of Neural Transmission Article Diltiazem or verapamil prevents haloperidol-induced apomorphine supersensitivity in mice Original Papers Published: September Volume 68 , pages —, Cite this article. Journal of Neural Transmission Aims and scope Submit manuscript. Summary Chronic thioridazine treatment in animals has been reported to produce less dopaminergic supersensitivity than other neuroleptics. Access this article Log in via an institution. Interactions of calmodulin kinase II with the dopamine transporter facilitate cocaine-induced enhancement of evoked dopamine release Article Open access 13 June Differential effects of acute and chronic antagonist and an irreversible antagonist treatment on cocaine self-administration behavior in rats Article Open access 24 May References Anath J Current psychopathological theories of tardive dyskinesia and their implications for future research. Author information Author notes J. Shelton Authors J. Grebb View author publications. View author publications. Rights and permissions Reprints and permissions. About this article Cite this article Grebb, J. Copy to clipboard. Search Search by keyword or author Search. Navigation Find a journal Publish with us Track your research.

Herald of Steel

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Waking up inside the ruins of an orphanage, Alexander finds himself chained and sold to slavery. A modern metallurgist, trapped in ancient times, watch as he tries to play with the cards fate dealt him. He will make plate armor, invent paper, build roads, teach governance and many more, as he tries to carve a place for himself. But how can such things not attract jealous eyes? The naval superpower- Cantagena, The unstoppable army of- Exolas, The superpower of the east- Adhania, The mercantile confederation- Sybarsis, The religious fanatics- Iyizarid, And the ever-present- Barbarians of the Barren Forrest, All want something from each other. In this ocean of sharks, follow a small carp as it struggles to leap through the dragon gate and establish a dynasty to outlast them all. The cover is not mine. If you are the owner of this cover, comment and I will remove it. After a long time in the darkness, a lost soul is transported to another world, and there the soul is given another chance and is reborn as a boy In a world of swords and magic, Zaos is given another chance after hearing an unknown voice asking him to protect someone. While he couldn't remember many things about his old life, he still decided to live his new as much as possible. Even though it looked like he was destined to do something, Zaos chose to follow his own path as much as possible. He tried that Weird things were happening in the kingdom he was born, and before he could imagine Zaos was throw in the middle of a war in which some were trying to revive the god of the world, and others were trying to prevent it. Zaos will fight in this war while he also looks for the person he is supposed to protect. The story, all names, characters, and incidents portrayed in this production are fictitious. No identification with actual persons living or deceased , places, buildings, and products is intended or should be inferred. Hurry, retreat! The best way to declare war on a spy as an ordinary person is to become a spy as well. As a spy, if you want to go to war with a powerful espionage organization, join an equally powerful espionage organization. If you are unable to join any powerful espionage organization, then establish your own espionage organization and fight until destruction or victory. This is the war of spies, telling the story of how a group of ordinary people achieved extraordinary success. Born as the heir to the world's most powerful family of magicians, with a talent for magic that rivals that of the gods, Adall knew happiness only to have it forcibly ripped away from him shortly thereafter. Overnight, he would be banished from his family and condemned to a pathetic life of wandering. Or so it was supposed to happen How did he become so powerful? Why am I unable to inflict even the slightest injury on him, even using my most powerful spells? Why must I lose to someone I could have killed with a mere murderous intent not long ago? His new calling will be to instill fear and despair in the hearts of his enemies. Inian shook his head, 'I know I couldn't. It's a rush, but I couldn't stay in constant danger for my entire life. I know that I can survive and be fine with you at my side, but eventually, I will need a quiet job. I think that I may want to do this for the rest of my life. It's great money, fun, and I get to fly around on a ship! I had just hoped maybe hoped that you would enjoy this as much as I did, and we could stay doing this for the rest of our lives. With nations at war fighting for land that giant monsters roam, Inian must find his place in the world. Hearing an echo of a voice saying that he is destined to rule with enormous power, what will he do with this knowledge? Will he protect himself and his family while keeping the peace? Or will he destroy the world instead? Will his son, Alaric face the same questions? Follow them on their journey and watch as one becomes the Ruler of Iron and Flesh! To make matters worse, he wakes up near Bunker Hill, mere hours before the famed Battle of Bunker Hill begins. Realizing the unique situation he finds himself in, the lieutenant takes the opportunity to change the fate of the battle and ensure an overwhelming American victory. Guided by his 'patronizing' 'God' and the American revolutionaries, Lieutenant Kim embarks on a journey to help America gain its independence and to ensure the nation upholds its 'most promising' ideals from the very beginning. Author's Warning: The story is very rough in the first few chapters and as some readers pointed out, some parts are laughable, such as 'American idealism'. However, the pace and quality of the story improve from chapter four and onwards. You will enjoy the story if you are interested in history, worldbuilding, and the butterfly effect along with a few badass characters. So even if you are a bit turned off initially, I promise that the story improves quickly. Some early details were accidentally left out, as I wrote the first two chapters a year before writing the third chapter. If you wish to support my writing, feel free to support me on Patreon. All my chapters will be free, but I appreciate a tip! In a land torn apart by war and ambition, Null Blackfyre carves a path to power with an iron will and unmatched martial prowess and a system. Download the app and become a Privileged reader today! Come take a sneak peek at our authors' stockpiled chapters! Download the app to get more new chapters! If possible, join me in the Win-Win event. Win me more chances of exposure through this event! Reveal spoiler. So far its amaizing. Just read 11 chapters and got me hooked up already. In the beginning Im confused about the countries whose enemy whose, maybe you can make a glosary or something. Im also curious how can a metalurgist good at medic and war strategic. Anyway just keep the momentun author, its promising already. Hi, This is the author shamelessly tooting his own horn. This story sprouted with me asking a simple question, 'what if I got stuck in Alexander The Great's time? Could I survive? Do you think you could have survived in ancient times with your modern knowledge? Follow me and find out. It feels like the story stopped moving, also the mc is a beta submissive to women he gets insulted in his face every time he just does nothing Such an incredible novel. The world is so amazing that i feel completely immersed in it. One of the absolute best in this site. I promise you wont regret reading this. Updating my review because I'm really not enjoying where the novel is going in the latest chapters. Really great the first couple hundred chapters but it eventually turns from bad to worse. All in all its massive drop in quality. I've stopped supporting his work, I'm no longer paying coins to read. Is there ntr netorare? This is it. The author had to have put crack cocaine in this book with how good it is. The intrigue, use of suspense, worldbuilding, schemes e. I highly recommend it any prospective readers. If Menes losses again, Alexander should replace this black general.. All he does it lose big battles. Why bring cavalry when you just want to play hide and seek in the Hills? I love this Kingdom building web novel. The world building and character development is amazing and realistic. I love how creating a blast furnace create political and economic problems. Like winning every war. Throughout the novel, the MC is also depicted as an intelligent and lustful man. However, woman can be dangerous. Perhaps, now the Mc will become acute when facing woman. This novel is amazing. Slowly building up the technology latter and adding new reforms. I love it. IMHO, this is the one of the best novel about kingdom building and war I've ever read. Currently, I've already read all available chapters. I wish author continue such breathtaking novel. Good luck everyone! The description is interesting, but I have a question. Does the MC have any desire to conquer more territory or is he just trying to survive? Herald of Steel Author: FerriticMatrix. The Guardians' Throne - The First Magic Swordsman After a long time in the darkness, a lost soul is transported to another world, and there the soul is given another chance and is reborn as a boy Spy-x-War Showdown The best way to declare war on a spy as an ordinary person is to become a spy as well. Not enough ratings. The War of the Primals Born as the heir to the world's most powerful family of magicians, with a talent for magic that rivals that of the gods, Adall knew happiness only to have it forcibly ripped away from him shortly thereafter. Dominion Of The Crown In a land torn apart by war and ambition, Null Blackfyre carves a path to power with an iron will and unmatched martial prowess and a system. Table of Contents. Latest Update Famous Bathhouse Part-5 4 hours ago. More Privileged Chapters Download the app and become a Privileged reader today! Frozentech Lv11 Frozentech. Dekol Lv14 Dekol FerriticMatrix Author FerriticMatrix. BaldRhaegar Lv4 BaldRhaegar. Melshan Lv7 Melshan. AncestorDuck Lv3 AncestorDuck. Daoistwaterdrop Lv14 Daoistwaterdrop. KrazyNight Lv11 KrazyNight. DaoistK80guv Lv10 DaoistK80guv. Power Ranking Power Stone See who voted. More about this book No One 17 and Under Admitted mature rating.

Triesenberg buy cocaine