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MDMA, commonly known as ecstasy, is primarily a recreational drug that causes euphoric feelings, increased empathy with others, and enhanced sensations. Sounds and colors are often experienced more intensely, making MDMA a popular recreational drug at raves and music festivals. It is most commonly taken as an oral tablet that comes in a variety of shapes and colors, but it can also be snorted or smoked. A common myth perpetuated by both the scientific community and media outlets is that MDMA was first synthesized and patented by the German pharmaceutical company Merck as an appetite suppressant. Merck did synthesize the drug in , but the appetite suppressant story is an urban legend. Instead, it was developed as a potentially life-saving blood clotting medicine. Very little, if any, testing was done in the early years after its first synthesis. A chemist named Max Oberlin predicted that MDMA might mimic adrenaline since the chemicals shared a similar molecular structure. Not long after these initial studies, however, the prices of a chemical precursors skyrocketed and testing was put on hold. It is not exactly known when the first human trials with MDMA were conducted, but the US military is known to have tested it and other drugs on humans in the s. Alexander Shulgin first read about MDMA in the early s at which point he synthesized it and tested on himself, becoming the first person to officially record ecstasy use in a human subject in Since , MDMA has been listed as a schedule I drug in the United States, making it effectively illegal for all uses, but some limited clinical trials have been approved and conducted in recent years. In , a federal court sided with the ACLU who argued that punishments for MDMA possession and use were based on outdated science which led to overly severe prison sentences, \\\\\\\\\\\\\\[3\\\\\\\\\\\\\\] but other courts have upheld the previous sentencing laws. Full results from the survey are below. These trends appear to be holding relatively steady:. Its appearance in published reports and literature reached a peak in the early- to mid- s and has fallen quite a bit since then:. Google search interest over the past decade or so has slowly but steadily increased before plateauing the past few years:. MDMA affects the brain by increasing activity levels of three different neurotransmitters: Its effects on the serotonin system cause characteristic changes in mood, appetite, sexual arousal, and sleep cycles. Spikes in serotonin after taking MDMA likely account for feelings of emotional closeness and empathy that are commonly reported by users. Potentially fatal neurological complications can occur following MDMA ingestion, likely due to short-term hypertension and dehydration that is induced by the drug. Necrosis of liver and heart tissue has also been reported in individuals where death was associated with the use of amphetamine derivatives. Clinical studies with pure MDMA have been conducted on over individuals without the occurrence of severe adverse effects. Most tablets available for recreational use contain between 80 and mg of MDMA. MDMA usually produces a relaxed, euphoric state, including emotional openness, empathy, reduction of negative thoughts, and a decrease in inhibitions. Sounds and colors can also appear more intense. Some adverse physiological effects can occur after ingesting MDMA and include elevated blood pressure and heart rate, nausea, chills, sweating, tremor, jaw clenching, hyperreflexia, urinary urgency, muscle aches or tension, hot and cold flushes, nystagmus, and insomnia. At higher doses, these physiological changes can result in severe adverse reactions. Secondary complications from increased body temperature are a risk, especially when taking higher doses of MDMA. Although one of the most famous ecstasy-related deaths was caused by overhydration, MDMA itself will not make you drink yourself to death. The victim in this infamous case thought that by drinking a large amount of water, they would counteract an unpleasant ecstasy experience. Unfortunately, MDMA also makes it harder for the body to process water, meaning she died from water retention. The main cause of ecstasy-related deaths is a lack of education. When used responsibly, it is a relatively safe drug. Many people take it in a spiritual or therapeutic context. It can be used for various forms of personal and relationship development , and clinical trials are using it to treat sufferers of post-traumatic stress disorder. There is no evidence that moderate use of MDMA less than mg every few weeks can cause damage to your brain. Frequent, high dose use can cause heart problems and memory problems. Overdoses can be lethal. The trials are being funded by MAPS. The drug used in these trials is pure, with dosages strictly controlled — unlikely the typical use of recreational ecstasy. Patients who have undergone this therapy typically have a particularly treatment-resistant form of PTSD many of them are war veterans. They report that MDMA-assisted therapy helped them approach their past trauma with a greater sense of acceptance, warmth, and compassion for themselves, allowing them greater opportunity to cope and heal. Preliminary results from a few studies suggest MDMA is also a promising treatment for social anxiety in individuals with autism. Early results suggest this is accomplished with infrequent or even single doses, eliminating the need for frequent administration of the drug, thereby mitigating the possible adverse side effects and many of the costs associated with longer-term, more involved therapies. This same mechanism appears operate in treating patients with life-threatening illnesses who experience clinical anxiety as well. Opinions vary among spiritual leaders and guides, but MDMA is sometimes cited as an tool that can be used for spiritual growth. Some spiritual teachers laud its ability to induce feelings of oneness, interconnectedness, empathy, compassion, warmth and kindness towards others, and, importantly, a lack of self-consciousness. States such as these are often catalysts for spiritual epiphanies and further spiritual and personal development. As one Benedictine monk put it:. There is a special quality to this conversation. One feels a heaviness, a sense of the weight of the moment, of something profound, of the seriousness of life itself. It is a space that is inner, without masks, without pretense, utterly open and honest. It is not an erotic intimacy, but a philosophical and mystical intimacy. Does this make any sense? One has the consciousness that this is an inner communication rarely achieved in ordinary discourse. There really are no adequate words to express this state of awareness, only to say, that it is essential in my experience. MDMA can be used in many different sets and settings to invoke spiritual development — from sitting quietly and introspecting, to meditating in groups, to therapy, even rolling at raves can have a spiritual quality if the user approaches it with the right intentions. MDMA could also be a useful tool for building or repairing relationships. The emotional intimacy produced by ecstasy could be the key to understanding our relationships and perhaps finding the places that need work. MDMA is structurally close enough to amphetamines that it can return a positive result in standard urine drug screens up to 5 days after use. It is also detectable in hair samples for up to 90 days. Testing kits can be purchased online , allowing you to test the purity and concentration of your pills. Making sure that you are actually ingesting MDMA, at sensible doses, is a crucial part of safe drug use. Ecstasy is most commonly ingested as an oral tablet. In powder form, MDMA crystal can be ingested orally or insufflated snorted. Many people mix the crystal into their drinks to avoid the bitter taste. Effects will take up to an hour to appear. MDMA depletes your serotonin levels, and microdosing could leave you with a long hangover. MDMA should probably only be used once a month at most, to avoid any dangers of long-term neurotoxicity. Therefore, it will produce a tolerance lasting several days. MDMA should not be mixed with other drugs, as some combinations can be very dangerous. Characterization of three new psychotomimetics. The Pharmacology of Hallucinogens. Pharmacological Reviews , 55 3 , — Journal of Psychopharmacology , 20 2 , — Drug and Alcohol Dependence , 60 1 , — Progress in Neuro-Psychopharmacology and Biological Psychiatry , 64 , — The New York Times. Novel psychopharmacological therapies for psychiatric disorders: The Lancet Psychiatry , 3 5 , — Your email address will not be published. MDMA is a potentially illegal substance, and we do not encourage or condone the use of this substance where it is against the law. However, we accept that illegal drug use occurs, and believe that offering responsible harm reduction information is imperative to keeping people safe. For that reason, this guide is designed to ensure the safety of those who decide to use the substance. Overview 01 MDMA, commonly known as ecstasy, is primarily a recreational drug that causes euphoric feelings, increased empathy with others, and enhanced sensations. Google search interest over the past decade or so has slowly but steadily increased before plateauing the past few years: Pharmacology 03 Receptor interactions MDMA affects the brain by increasing activity levels of three different neurotransmitters: Toxicology Potentially fatal neurological complications can occur following MDMA ingestion, likely due to short-term hypertension and dehydration that is induced by the drug. So although sensible use is relatively safe, it can be harmful in large amounts. Personal Growth 07 Opinions vary among spiritual leaders and guides, but MDMA is sometimes cited as an tool that can be used for spiritual growth. As one Benedictine monk put it: FAQ 08 Can it be detected in a drug test? Does it produce tolerance? Can I mix it with other drugs? Footnotes 09 \\\\\\\\\\\\\\[1\\\\\\\\\\\\\\] Shulgin, A. Learn more about MDMA. Leave a Reply Cancel reply Your email address will not be published.