Pth C Sex

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Affiliations
1 1 Department of Endocrinology and Metabolic Diseases, Kartal Dr. Lutfi Kirdar Training and Research Hospital , Istanbul, Turkey .
2 2 Department of Family Medicine, Kartal Dr. Lutfi Kirdar Training and Research Hospital , Istanbul, Turkey .
Sule Temizkan et al. Metab Syndr Relat Disord. 2015 Dec.
Affiliations
1 1 Department of Endocrinology and Metabolic Diseases, Kartal Dr. Lutfi Kirdar Training and Research Hospital , Istanbul, Turkey .
2 2 Department of Family Medicine, Kartal Dr. Lutfi Kirdar Training and Research Hospital , Istanbul, Turkey .
Background: In this study, we aimed to investigate whether high parathormone (PTH) levels in obese patients contribute to the metabolic complications of obesity.
Methods: A total of 400 obese subjects aged 18-65 years were included. Anthropometric bioelectrical bioimpedance measures, blood tests, and 75 gram oral glucose tolerance test results were evaluated.
Results: Of the 400 obese subjects, 335 were female. The mean age was 39 ± 10 years. The median body mass index was 36 (interquartile range 34-41). Subjects were divided into quartiles according to blood PTH levels. Groups included quartile 1 [n = 100, median PTH; 42 (range 36-45)], quartile 2 [n = 100, median PTH; 55 (51-59)], quartile 3 [n = 100, median PTH; 73 (68-78)], and quartile 4 [n = 100, median PTH; 99 (89-125)]. Quartiles were evaluated with a generalized linear model adjusted for age, sex, and season of recruitment. Systolic and diastolic blood pressure, fasting glucose, homeostatic model assessment-estimated insulin resistance, insulin sensitivity index, triglyceride level, and high-density lipoprotein cholesterol (HDL-C) were not different among quartiles. PTH and 25 hydroxyvitamin D (25(OH)D) were not associated with higher odds of prevalent metabolic syndrome in obese subjects (odds ratio, OR, 0.99 [95% confidence interval, CI, 0.981.00], P = 0.38 and 0.99 95% CI 0.96-1.01], P = 0.46, respectively). Decreased 25(OH)D levels were significantly correlated with higher odds of low HDL-C (OR 0.96 [95% CI 0.93-0.99], P = 0.04).
Conclusions: PTH does not contribute to the occurrence of metabolic components of obesity, but there is a positive correlation between 25(OH)D and HDL-C.
Guasch A, Bulló M, Rabassa A, Bonada A, Del Castillo D, Sabench F, Salas-Salvadó J. Guasch A, et al. Cardiovasc Diabetol. 2012 Dec 11;11:149. doi: 10.1186/1475-2840-11-149. Cardiovasc Diabetol. 2012. PMID: 23228198 Free PMC article.
Lee SH, Kim SM, Park HS, Choi KM, Cho GJ, Ko BJ, Kim JH. Lee SH, et al. Nutr Metab Cardiovasc Dis. 2013 Aug;23(8):785-91. doi: 10.1016/j.numecd.2012.04.013. Epub 2012 Jul 3. Nutr Metab Cardiovasc Dis. 2013. PMID: 22762845
Alemzadeh R, Kichler J. Alemzadeh R, et al. Metab Syndr Relat Disord. 2016 Apr;14(3):167-74. doi: 10.1089/met.2015.0099. Epub 2016 Jan 29. Metab Syndr Relat Disord. 2016. PMID: 26824485
Lloyd LJ, Langley-Evans SC, McMullen S. Lloyd LJ, et al. Int J Obes (Lond). 2012 Jan;36(1):1-11. doi: 10.1038/ijo.2011.186. Epub 2011 Nov 1. Int J Obes (Lond). 2012. PMID: 22041985 Free PMC article. Review.
Crespo PS, Prieto Perera JA, Lodeiro FA, Azuara LA. Crespo PS, et al. Public Health Nutr. 2007 Oct;10(10A):1121-5. doi: 10.1017/S1368980007000596. Public Health Nutr. 2007. PMID: 17903319 Review.

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Pth C Sex