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The First Pass Effect FPE is a built-in protective mechanism which we have, that causes toxic substances that we swallow, to be broken down before they get distributed throughout our bodies to places where they can cause harm. The FPE works by taking the blood which contains toxins absorbed from our gastrointestinal tract GI tract straight to the liver where they are broken down. This metabolic procedure normally makes the toxins water soluble, so they can be excreted through the kidneys. Notice from the diagram credit Wikipedia how all the blood vessels that carry substances which have been absorbed from the stomach and intestines these are coloured red, yellow, green, and purple into the Hepatic portal vein coloured black and into the liver. The FPE is of vital interest to the pharmaceutical industry because our bodies do not distinguish between toxins and pharmaceuticals. For example, the antiviral drug, Remdesivir cannot be administered orally because the entire dose would be eliminated by the liver. In this case remdesivir must be administered by a non-oral route. Another example is glyceryl trinitrate nitroglycerine , which is a medicament used for heart failure, high blood pressure, anal fissures, painful periods, and to treat and prevent chest pain caused by decreased blood flow to the heart angina. It is completely eliminated from the body by the FPE and must be administered intravenously, as a sublingual spray or tablet , or as a patch applied to the skin. Nicotine is a toxic alkaloid found in the leaves of some plants; it acts on the central nervous system CNS. If such leaves are eaten, we are protected because of the FPE, all the nicotine is metabolised by the liver before it can act on the CNS. Cocaine is another plant-based alkaloid that acts on the CNS. To do this, it must get to the brain, so when taken orally, the FPE prevents this from happening, unless a very large amount is digested. Solanine is a glycoalkaloid that is an acetylcholinesterase inhibitor; its complete mode of toxification is still being investigated. It is found in species of the nightshade family within the genus Solanum, such as the potato Solanum tuberosum , the tomato Solanum lycopersicum , and the eggplant Solanum melongena. It can occur naturally in any part of the plant, including the leaves, fruit, and tubers. Of particular concern are green tomatoes and potatoes that have turned green normally by exposure to the sun. The green parts contain seven times the level of solanine than the rest of the potato. That is, it has a low oral toxicity. This low oral toxicity is a result of its quick removal from the body into both the urine and the faeces, usually within 12 hours, thanks to the FPE, thereby preventing it accumulating in the tissues. In the liver, it is metabolised to the water soluble solanidine and excreted through the kidneys. The First Pass Effect is just one example of design built into our bodies, all of which are for our benefit and enable us to function the way God intended. He loves us and we have been created in His image so that we may intimacy with Him. Examples of design are ubiquitous throughout creation and of course, they all point to the Designer. To say that everything came about through random process of atoms banging into each other is preposterous and laughable. Your email address will not be published. Post Comment. Introduction The First Pass Effect FPE is a built-in protective mechanism which we have, that causes toxic substances that we swallow, to be broken down before they get distributed throughout our bodies to places where they can cause harm. A few examples of the FPE preventing illness and even death Nicotine is a toxic alkaloid found in the leaves of some plants; it acts on the central nervous system CNS. Conclusion The First Pass Effect is just one example of design built into our bodies, all of which are for our benefit and enable us to function the way God intended. Search for:. Print this page: Print. Leave a Reply Cancel reply Your email address will not be published. Save my name, email, and website in this browser for the next time I comment. Be kept informed! Subscribe to my monthly blog.

HILLARY AND BILL CLINTON, THE DRUGS VOLUME

Oberammergau where can I buy cocaine

Libraries and archives collect materials from different cultures and time periods to preserve and make available the historical record. As a result, materials such as those presented here may reflect sexist, misogynistic, abusive, racist, or discriminatory attitudes or actions that some may find disturbing, harmful, or difficult to view. Both a humor and literary magazine, The Pine Needle was a University of Maine periodical that began publication in the fall of , the first post-World War II semester that saw GIs returning to campus. Of the 32 student staff members listed in the publication's November mast head, the Managing Editor Dana T. The Needle reflected an edginess, sophistication, and rebellion not found in previous UMaine student publications which reflected a sense of homely, shared cultural experiences among students. While past student publications relied on veiled euphemisms for drunkenness and dating on campus, The Needle crashed out of the gates with an emphasis on sex and sexualizing co-eds, as well as the use of drugs, tobacco, and alcohol by students returning from war. Cover art for this issue is by Bonnie Cratty of Bangor. The chalk illustration depicts a pair of disembodied lips smoking a pipe hovering above a fuller pair of disembodied lips smoking a cigarette. Tobacco smoke trails upward, spelling out the words 'Pine Needle. Following graduation, Cratty found employment with the U. Displaced Persons Commission in Frankfurt, Germany. She later transferred to the office of the U. Consulate, Munich, Germany and finally the U. Army Intelligence School, Oberammergau, Germany. Following her marriage to Major Meade Klemme of the U. Air Force, the couple settled in Fairfield, California. General University of Maine Publications. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. In addition, no permission is required from the rights-holder s for educational uses. For other uses, you need to obtain permission from the rights-holder s. Advanced Search. Home My Account Accessibility Statement. Skip to main content. Document Type Other. The Pine Needle, November Editor Dana T. Whitman, managing editor. Ralph Flynn, assistant editor. William Horner, feature editor. Publisher University of Maine. Publication Date Publisher location Orono, Maine. Version publisher's version of the published document. Rights Statement. Search Enter search terms:. Elsevier - Digital Commons.

Oberammergau where can I buy cocaine