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Findings could help address an unmet medical need and shed light on the molecular underpinnings of addiction. Researchers at University of California San Diego School of Medicine and the Salk Institute for Biological Studies have created a unique, cell-by-cell atlas of the amygdala, a small structure deep within the brain that plays a crucial role in controlling emotional responses to drugs. The findings, published October 5, in Nature Neuroscience , helped the researchers identify a potential new treatment for cocaine addiction, a disease that is poorly understood at the molecular level and has virtually no approved pharmacological treatments. Cocaine is a widely used illicit drug and addiction to cocaine is a major public health concern, associated with a rising number of overdose deaths and a high rate of relapse. Despite the threat cocaine addiction poses, not every person who uses cocaine develops an addiction. According to the National Institute on Drug Abuse , an estimated 4. The researchers studied brain samples from rats that had been allowed to self-administer cocaine for an extended period before being cut off from the drug for a period of abstinence. Jess Zhou, a UC San Diego graduate student working with McVicker, developed the bioinformatics workflow needed to assemble their sequencing data into a molecular atlas of the rat amygdala. The results revealed never-before-seen connections between addiction behaviors and genes involved in energy metabolism. In addition to identifying molecular factors that influence cocaine addiction behaviors, the researchers were able to test a drug in the rats that helped reverse these behaviors by targeting an enzyme involved in both energy metabolism and signaling between neurons. The researchers are now working on larger sample-size studies that can help determine how much of the effects they observed were based on preexisting genetics in the rats and how much were based on responses to extensive cocaine usage. Disclosures: Abraham A. Keep up with all the latest from UC San Diego. Subscribe to the newsletter today. Signup to get the latest UC San Diego newsletters delivered to your inbox. Award-winning publication highlighting the distinction, prestige and global impact of UC San Diego. Cellular Atlas of Amygdala Reveals New Treatment Target for Cocaine Addiction Findings could help address an unmet medical need and shed light on the molecular underpinnings of addiction. Story by: Miles Martin - milesmartin ucsd. Published Date October 05, Article Content Researchers at University of California San Diego School of Medicine and the Salk Institute for Biological Studies have created a unique, cell-by-cell atlas of the amygdala, a small structure deep within the brain that plays a crucial role in controlling emotional responses to drugs. Unraveling these genetics will be key to improving personalized medicine for addictions. Topics covered: cocaine addiction neurons neuroscience brain amygdala Share This:. You May Also Like. Open laptop with stethoscope on keyboard and human hands in background. Subscription Notification Close Confirmation. Thank you!

Cellular Atlas of Amygdala Reveals New Treatment Target for Cocaine Addiction

Naryn where can I buy cocaine

According to the World Drug Report, about million people worldwide, which is roughly 5. Some 31 million of people who use drugs suffer from drug use disorders, meaning that their drug use is harmful to the point where they may need treatment. Some , people died in as a result of drug use. Of those deaths, , were directly associated with drug use disorders mainly overdoses. Some 50 representatives of governmental bodies, international organizations, civil society and media took part at the State Coordination Committee on drug control meeting held on 28 June, devoted to the 26 June - International Day Against Drug Abuse and Illicit Drug Trafficking. The coordination committee aims at consolidation of efforts of all state institutions in creating an effective model of coordination in the sphere of drug control at national level. According to the World Drug Report , presented today by the United Nations Office on Drugs and Crime UNODC , drug markets are expanding, and the production of cocaine and opium reaches absolute record levels, presenting numerous challenges on several fronts. Between and , the number of deaths caused directly by drug use increased by 60 percent. I am convinced that a systematic approach and active efforts at all available levels will contribute to combating illicit drug trafficking and will have a positive impact on security both in the Kyrgyz Republic and in the region as a whole. The Kyrgyz Ministry of Interior, the State Committee on National Security of the KR, the State Border Service of the Kyrgyz Republic and the State Penitentiary Service signed a regulation on cooperation in the sphere of combating illicit trafficking of drugs, psychotropic substances and their precursors. During the meeting, issues on the national and regional drug situation reviewed, results of the implementation of the Action Plan for the implementation of the Government's Antinarcotics Program announced, access to legal drugs and psychotropic substances for medical purposes in the country discussed. US dollars to support for drug control efforts in Kyrgyzstan. These efforts will be aimed at supporting strong national legislation on drug control, national operational capacities on drug law enforcement, as well as for enhancing the capacities of other competent authorities in maintaining the legal turnover of controlled narcotic drugs, psychotropic substances and precursors under the ratified UN conventions. As part of a balanced and comprehensive integrated strategy, the health consequences of drug use especially for the young and vulnerable population will also be addressed. WorldDrugDay, under the slogan - 'Listen First'. Welcome to the United Nations. United Nations. Site Search Search the site. Home Contacts Fraud Alert.

Naryn where can I buy cocaine