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Depending on the dose, purity of the substance, and frequency of dosing, MDMA can be neurotoxic , meaning it is harmful to the cells of the nervous system. Specifically, studies have found that high doses of MDMA given to rodents can damage the nerve cells neurons that release the feel-good neurotransmitter serotonin. While the flood of serotonin that happens during an MDMA trip is, in part, what makes it such a potent medicine, the drop in serotonin levels after the trip can make us feel down, tired, depressed, or flu-like in the days that follow. One theory is that MDMA creates unstable molecules known as free radicals. Oxidation caused by free radicals can injure our cells and even damage our DNA. Over time, oxidative stress increases the risk of numerous chronic health issues. Thankfully, certain types of nutrients might help offset the oxidative stress associated with MDMA. Popular antioxidants you can find in the grocery store include green tea, berries, walnuts, and dark chocolate. When it comes to oxidation associated with MDMA, the antioxidants alpha lipoic acid, acetyl-L-carnitine, N-acetyl cysteine, and ascorbic acid may be worth supplementing. One week after receiving MDMA, the rats in this study were killed and their brains were examined. A study on acetyl-L-carnitine ALC likewise yielded promising outcomes. All of the rats were killed two weeks later, and their brains were examined. The brains of the rats that received only MDMA were found to have significant evidence of neurotoxicity and mitochondrial damage. Serotonin plays an important role in our ability to regulate body temperature. In fact, hyperthermia is another proposed mechanism by which MDMA causes neurotoxicity. NAC is a precursor to a very important antioxidant known as glutathione. And it might just prevent MDMA-induced hyperthermia. This was measured by rectal thermometers, which I can only imagine were hilariously tiny. Prior to being killed, the rats were also placed in a maze so that their memory could be assessed. Another study found that vitamin C given before MDMA reduced the risk of hyperthermia and protected against the dip in serotonin levels typically seen after using MDMA. Vitamin C is one of the most under-celebrated antioxidants. Widely available and affordable, vitamin C may even help protect the brain against certain aspects of opioid addiction. In fact, other studies have shown that MDMA-related harm can linger in both animals and humans. This risk is especially high in women, as a study of ravers in Amsterdam found that women might be more susceptible than men to the neurotoxic effects of MDMA. This study confirmed similar findings from a study comparing the neurotoxicity from MDMA in female and male rats. Teenagers may also be at increased risk of MDMA-related neurotoxicity, as at least two rat studies have suggested. The study confirms previous research suggesting that habitual use of ecstasy may cause long-term cognitive and psychiatric issues. However, a meta-analysis of 16 studies of Ecstasy users compared to controls showed decreased levels of the serotonin reuptake transporter SERT , the primary receptor that MDMA binds to in the brain. There was an association of time since last use, but not with lifetime occasions of Ecstasy use. These findings suggest that changes in SERT levels may be reversible over time, and other variables, such as a number of doses taken per occasion, may play a role in the degree of changes in SERT levels. In summary: taking ecstasy too many times can potentially change your brain for the worse, and it is unclear if those changes will resolve on their own. As with any medicine, the risks of MDMA must be weighed against the benefits. For individuals seeking to overcome post-traumatic stress disorder PTSD , repair their marriage , or otherwise learn, grow, and heal, the risk of side effects that come with a limited number of MDMA-assisted psychotherapy sessions may very well be worth the risk. Using some over-the-counter antioxidants may significantly reduce that risk or even shrink it to zero. Some scientific evidence suggests that we can minimize the risk of side effects from MDMA by taking antioxidant supplements. Based on the data, possible supplement regimens to accompany MDMA sessions could include any combination of the following:. Other powerful antioxidants may also be helpful. Nevertheless, these supplements all have pretty good safety profiles:. Drawing on common sense, it also seems intuitive to avoid other activities and substances that cause oxidative stress when planning an MDMA trip. This includes avoiding alcohol-containing beverages, cigarettes and second-hand cigarette smoke , and foods made with refined sugars or heavily processed ingredients. It also means avoiding settings where there may be high radiation, chemicals, or poor air quality. As infections also cause oxidation in the body, it may be helpful to reschedule any MDMA sessions if you have a cold, flu, herpes outbreak, unexplained fever, or other signs of infection. It can also be a good idea to avoid getting a vaccine the same week as doing an MDMA session. Because of the effects that MDMA can have on anti-diuretic hormone ADH levels in the body, I typically recommend that folks keep their water intake to under 3 liters of electrolyte-enhanced water. The risk with 5-HTP supplements, however, is that they can actually work at increasing serotonin levels. Eating Disorders Workshop - Oct 24th. Get Therapy Education Articles. February 20, Updated: March 28, Follow your Curiosity Sign up to receive our free psychedelic courses, 45 page eBook, and special offers delivered to your inbox. Sign Up. The content provided is for educational and informational purposes only and should be a substitute for medical or other professional advice. Articles are based on personal opinions, research, and experiences of the author s and do not necessarily reflect the official policy or position of Psychedelic Support. Clinical Observations on the Role of Microdosing in Psychotherapy. Potential Treatment of Psilocybin for Lyme Disease. Nina Izel Harm Reduction - October 8,

Chitre buy Ecstasy