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Anti-TNFs are first-line biological agents in our country, and for that reason, the discrimination of patients who will be refractory of those therapies before treatment is relevant to prevent IBD patients from the exposition to multiple therapeutic failures. Therefore, we wanted to isolate robust and reproducible transcriptional markers able to specifically predict the response to anti-TNF therapy, which will contribute to targeted prevention, improve individual outcomes and decrease therapy expenditures. R package was used to perform the differential expression analyses and calculation of receiver operating characteristic ROC. Cytoscape software and Morpheus broadinstitute. We isolated a transcriptional signature composed of eight metalloproteases MMPs with high association with disease activity. Most of the transcripts of that signature were significantly upregulated in colon biopsies of non-responder patients to anti-TNFs before treatment in three different microarray datasets, but not in vedolizumab-treated patients. Overall, our study revealed a novel and robust MMP-transcriptional signature associated with anti-TNF but not vedolizumab therapy response. Nevertheless, our results should be corroborated in independent cohorts of patients with UC to test their efficacy and sensitivity in the clinical setting. Our data definitively contribute to the change from a reactive approach to predictive, preventive and personalised medicine. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Advertisement intended for healthcare professionals. Sign in through your institution. ECCO Journals. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Journal Article. P Isolation of a novel metalloproteinases transcriptional signature with robust anti-TNF therapy predictive power in patients with Ulcerative Colitis. Oxford Academic. Google Scholar. R Ferreiro-Iglesias. M Porto. L Nieto. M Barreiro-de Acosta. J Conde-Aranda. Select Format Select format. Permissions Icon Permissions. Abstract Background. All rights reserved. For permissions, please email: journals. Issue Section:. Download all slides. Views More metrics information. Total Views Email alerts Article activity alert. Advance article alerts. New issue alert. Subject alert. Receive exclusive offers and updates from Oxford Academic. Citing articles via Google Scholar. Mucosal cytokine expression associated with deep endoscopic mucosal healing in ulcerative colitis. The circulating methylome in childhood-onset inflammatory bowel disease. The intestinal mucin isoform landscape reveals region-specific biomarker panels for inflammatory bowel disease patient stratification. More from Oxford Academic. Clinical Medicine. Medicine and Health. Authoring Open access Purchasing Institutional account management Rights and permissions. Get help with access Accessibility Contact us Advertising Media enquiries.

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We were in McAllen, a city that sprawls across the Texas-Mexican border. We had come to investigate the smuggling of American weapons across the border where they are driving a spiral of violence. Barely known is the fact, that US gun laws are having a deadly impact in Mexico , too. According to a report from the US Government Accountability Office, a staggering 70 percent of all crime guns recovered and traced in Mexico between and could be traced back to the United States. Mexico is witnessing an unprecedented explosion in violence caused by the wars over the drug trade. It had been a relief to reach the safety of McAllen after crossing the border in Reynosa. Two heavily armed police escorts had given us protection and it was made clear that under no circumstances must we stop to film on the Mexican side. But those who live in Reynosa do so facing an escalating murder rate. In September alone, over people were killed, up by percent from the year before. This border state has the highest number of disappeared people in Mexico and the hills around the state capital are still home to the cartels who make it too dangerous for security forces to start proper searches for dead bodies. Captain Edgar Vallejo Arosa and his team told us that the cartels often had more weapons and ammunition than they did. They showed us houses that had seen gun battles, but it was the visit to the state prison that proved most memorable: Barely two months earlier, a massive riot had broken out after corrupt officers had allegedly helped smuggle in weapons. Vallejo Arosa told us prisoners shot at officers with long guns and had a supply of around 6, bullets. Three officers from his team died before the prison was retaken. He said weak US gun laws carried some blame but that requests to introduce stricter controls on the sale of automatic weapons in the US had fallen on deaf ears. We would like these sales to be limited to sport guns, for personal defence. Once we were in Texas, we found that US federal investigators agreed. Nicole Strong and Frank Ortega, agents for the Bureau of Alcohol, Tobacco, Firearms and Explosives ATF explained that they, too, face a problem of legislation: the US lacks a firearms trafficking statute meaning there is no law under which the trafficking of firearms to be prosecuted. The firearms trafficking statute One of the few legal tools that the ATF has to spot potential traffickers is an Obama-era reporting requirement for multiple purchases of assault rifles. This obliges a licensed firearms dealer in a US border state to report any buyer who purchases several semi-automatic rifles of a particular type within a short period of time. Not much, one might think, but even this reporting requirement is under fire. A handful of congressmen are using a bill to try and cancel it, and with President Donald Trump at the helm, they may well succeed. None of this, however, appeared to concern the unidentified man who sold us the AK in the car park of the filling station. On his website, he had at least four other rifles for sale, but as long as he can credibly claim that he is a private seller rather than a commercial one, he can trade virtually outside the limits of the law and sell them to anyone without asking who they are. A week after patrolling with the officers from the Tamaulipas State Police, who are targeted with these kinds of rifles every day, it was an extremely gratifying thing to do. Video Duration 26 minutes 00 seconds By Juliana Ruhfus. Published On 21 Mar 21 Mar Sponsored Content.

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