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Author: Cheng Hua. Interactions between the variables of predisposing i. Genetic variations to addiction susceptibility and environmental factors such as stress or social defeat also alter brain-reward mechanisms impart vulnerability to addiction. The emergence and maintenance of addiction might be the consequences of chronic exposure to drugs remodeling the chromatin structure including FosB, Cdk5, G9a, and BDNF around genes. Only few drugs for substance use disorders SUDs are approved by the FDA, But QSP approaches provide valuable strategies for designing novel prevention or treatment towards drug addiction. Conjugate vaccines and monoclonal antibodies treatments generating high-affinity anti-drug IgG antibodies neutralizing drug doses in the serum might lead the immunotherapy for SUDs in the future. Kranzler H. Drug Alcohol Depend ,83 Suppl. Addiction , Suppl. S Hebebrand J. Psychol Med ,16, Orford J. Findings from a sample of treatment-seeking patients with CB. Boredom proneness interacts with cue-induced craving and avoidance expectancies in explaining symptoms of Internet-communication disorder. Neuroadaptation, stress, and conditioning factors. CJ Yang X. Nat Genet ,33 S3 Suppl. Cell Stem Cell ,22 4 , C2 Koob G. CD Bentley A.
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