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Cannabis sativa contains more than known compounds, of which the terpene chemicals, called cannabinoids, are unique to this species. The cannabinoids, which occur as the corresponding acids in the plant material, are the major psychoactive components in this species. The compounds are decarboxylated from the inactive acidic form into the active form by means of smoking. Previous research has made use of the tobacco industry's standard method and adaptations thereof to produce a cannabis smoke condensate. In this study the method of smoke production, which includes the puff frequency, puff length, and puff volume, was tested and the concentration of the major cannabinoid, Delta 9 -tetrahydrocannabinol THC , and the amount of by-products produced under the different conditions were quantified. This study aimed at combining the existing methodology and at providing quantitative results on the influence of the preparation method on the concentration of THC in the smoke. The results indicate that the method of smoke production influences the amount of THC produced e. The THC concentration in the smoke condensate varied between Abstract Cannabis sativa contains more than known compounds, of which the terpene chemicals, called cannabinoids, are unique to this species. Publication types Research Support, Non-U. Substances Hallucinogens Smoke Dronabinol.

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