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The rise is thought to reflect both more people consuming the drug and the widespread availability of high dose pills and high purity MDMA powder. While some causes of death such as liver failure and SIADH water intoxication are pretty random, others such as hyperthermia, overheating , dehydration and possibly cardiovascular incidents are more predictable and potentially avoidable. MDMA dose, polydrug use and behaviours like physical exertion and not rehydrating might all be possible points of intervention that could reduce these risks of harms associated with the use of MDMA. We also know that the risk of harm increases with frequency of use. Doses of over mg are considered high, because this the upper limit used in human studies and shown to be safe within clinical settings. In the absence of any obvious change in either accompanying behaviours or polydrug use patterns, the recent spike in deaths is most likely to be attributable to more people taking MDMA and the larger doses some people especially younger are taking. MDMA time to onset and redosing. The effects of MDMA when taken orally usually begin after 30—45 mins this can show very wide variation with onset being much quicker after dissolved powder and much slower with some highly compressed pills. After a dose of mg people report peaking at 60—90 mins and start to come down after hours. Consequently, many users take further doses if they want their evening to continue. The problem is that the way our bodies breakdown MDMA can be unpredictable and varies between people and redosing can be difficult to get right. MDMA is broken down in your body by enzymes in your liver. This means that your body may become less effective at breaking down MDMA after a certain dose. The consequence of this is that small increases in MDMA dose can lead to unexpectedly large increases in blood level. The higher the blood level of MDMA, the greater the increases are in things like heart rate, blood pressure and other stresses on your body. The scientific term for disproportionate increases in blood level following small increases in dose is known as non-linear kinetics. That is very sensible. But because of differences in our genetic make-up, people breakdown MDMA differently, especially after they have taken a first dose. Second doses taken by different people can lead to very different effects; one might feel unwell, while another just gets a better buzz. In addition, the link between how much you take, and your blood level depends on the size of each dose, the time you leave between doses and whether or not you have consumed alcohol. GDS has already identified that being drunk before you take your first dose is big risk for seeking emergency medical treatment. So dosing is complex, and the results may be unpredictable. Ending up in the emergency department is fortunately rare, suggesting most people have worked out how to use MDMA without experiencing severe harm. The risks are higher for young people and women. This year we want your help to better identify dosing patterns associated with risk. We want to know how and when you decide to take a second dose or third dose how this alters your experience. This will add to the findings from previous surveys and will help us develop even more nuanced advice to people, who we know want to have fun, stay safe and keep their mates safe. So if you have taken MDMA in the last 12 months and want to help us make drug use safer for other people, please take minutes to take part in GDS www. If you value our research, we would greatly appreciate your contribution Please help us continue in our work. GDS Drug policy and the law: understanding your views and experiences GDS What would it take to get you to stop skinning up your joints with tobacco? GDS No and low alcohol beverages: are they worth a shot? A bit of science…. The higher the blood level of MDMA, the greater the increases are in things like heart rate, blood pressure and other stresses on your body The scientific term for disproportionate increases in blood level following small increases in dose is known as non-linear kinetics.

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Ecstasy comes in pill or powder form. Ecstasy pills can be white, coloured, round, square or pressed into any shape. Some pills have designs stamped into them, like well known company logos that the pills are then named after. They both taste bitter and unpleasant. Ecstasy pills are usually swallowed, although some people crush them up and snort them. The amount of MDMA in ecstasy pills varies massively. Some pills sold as ecstasy actually contain other, more dangerous, drugs that take longer to kick in. Drinking too much including water can also be dangerous. Users should sip no more than a pint of water or non-alcoholic drink every hour. MDMA users often start by dabbing just a small amount of powder and waiting for the effects to kick in. Like with pills, drinking too much including water can also be dangerous. Ecstasy can also make people feel more in tune with their surroundings and like the music is more intense, which is why people sometimes take it in nightclubs and at parties. Lots of people feel very chatty and uninhibited on ecstasy, which makes them open up and talk about things they might not do normally. When taken orally, ecstasy normally takes 30 minutes to kick in, but it could take as little as 20 minutes, or it may take over an hour or more. Some other more dangerous drugs sold as ecstasy take longer to kick in. Users tend to feel high for 2 to 4 hours. You might still experience some physical effects, like a fast heart beat or insomnia not being able to sleep , for a few hours after you stop feeling high — especially if you take a lot. This can last for several days. How long a drug can be detected for depends on how much is taken and which testing kit is used. This is only a general guide. Evidence suggests that long-term users can suffer from memory problems and may develop depression and anxiety. Even testing kits may not find everything. You may be at risk from other drugs and ingredients added to the pill or powder, as well as to the ecstasy itself. Ecstasy pills are sometimes cut with amphetamines like speed , caffeine and other substances that have some similar effects but are cheaper to produce. Some pills are cut with stimulants that are slower to kick in than MDMA, and so users have taken more of the pill or pills and then overdosed. Always start by taking a half or a quarter of a pill first — you may find that is enough. MDMA powder can also be cut with other ingredients. You should always start by taking a very small amount to begin with and wait for the effects to kick in before deciding whether to take anymore. It's possible to build up tolerance to ecstasy, which means people need to take more of the drug to get the same buzz. You may also develop a psychological dependence, which is a strong desire to keep on using even if you think your use is having harmful consequences. Supplying someone else, even your friends, can get you life in prison, an unlimited fine or both. Like drink-driving, driving when high is dangerous and illegal. If the police catch people supplying illegal drugs in a home, club, bar or hostel, they can potentially prosecute the landlord, club owner or any other person concerned in the management of the premises. Skip to main content. Quick info. How the drug works varies from person to person. How it looks, tastes and smells What does it look like? How do people take it? Ecstasy pills Ecstasy pills are usually swallowed, although some people crush them up and snort them. How it feels How does it make you feel? Some users have reported feelings of: anxiety panic attacks confused episodes paranoia and even psychosis after taking ecstasy. Physical side effects can include: dilated pupils tingling sensations tightening or moving of the jaw muscles gurning raised body temperature a faster heartbeat and nausea. To kick in When taken orally, ecstasy normally takes 30 minutes to kick in, but it could take as little as 20 minutes, or it may take over an hour or more. How long it lasts Users tend to feel high for 2 to 4 hours. Ecstasy can normally be detected in a urine test between 1 to 4 days after taking it. The risks Physical health risks Because the strength of ecstasy pills are so unpredictable, if you do decide to take ecstasy, you should start by taking half or even a quarter of the pill and then wait for the effects to kick in before taking anymore — you may find that this is enough. Use of ecstasy has been linked to liver, kidney and heart problems. Some users report getting colds and sore throats more often when they take ecstasy. Anyone with a heart condition, blood pressure problems, epilepsy or asthma can have a very dangerous reaction to the drug. Ecstasy affects the body's temperature control. Dancing for long periods in a hot atmosphere, like a club, increases the chances of overheating and dehydration. Users should take regular breaks from the dance floor to cool down and watch out for any mates who are on it — as they might not realise they're in danger of overheating or getting dehydrated. This is because ecstasy can cause the body to release a hormone which stops it making urine. If you drink too quickly you might affect your body's salt balance, which can be as deadly as not drinking enough water. Mixing Is it dangerous to mix with other drugs? Mixing drugs is always risky but some mixtures are more dangerous than others. What happens if I mix Ecstasy and Select a drug. Addiction Can you get addicted? The law Class: A This is a Class A drug, which means it's illegal to have for yourself, give away or sell. Possession can get you up to 7 years in prison, an unlimited fine or both. Was this information useful? Yes No.

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