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Declaration: As with all diagnostic tests, a definitive clinical diagnosis should not be based on the result of a single test, but should only be made by the physician after all clinical and laboratory findings have been evaluated. The test device contains membrane strips which are pre-coated with drug conjugate on the test band T. A red colored anti-colloidal gold conjugate pad is placed at the right end of the membrane. After dipping into urine the gold-conjugates move upward chromatographically by capillary action and the antibodies get to the test region. If there is no drug molecule in the urine the antibody gold conjugate attaches to the drug conjugate to form a visible line. Therefore, the formation of a visible precipitant in the test zone occurs when the test urine is negative for the drug. When sufficient concentration of the drug is present, it will fill the limited antibody binding sites. This will prevent attachment of the colored antibody-colloidal gold conjugate to the drug conjugate zone on the test band region. Therefore, absence of the colored band on the test region indicates a positive result. This control line should always appear, regardless of the presence of drug and metabolite. This means that negative urine will produce two colored bands, and positive urine will produce only one band. The presence of this colored band in the control region therefore serves as 1 verification that sufficient volume has been added, and 2 that proper flow was obtained. For In Vitro use only 2. For professional use only 3. Urine specimens may be potentially infectious. Proper handling and disposal methods should be established. Avoid cross-contamination of urine samples by using a new specimen collection container and specimen pipette for each urine sample. Fresh urine does not require any special handling or pretreatment. Urine samples should be collected such that testing can be performed as soon as possible after the specimen collection, preferably during the same day. Specimens that have been refrigerated must be equilibrated to room temperature prior to testing. Specimens previously frozen must be thawed, equilibrated to room tempera-ture, and mixed thoroughly prior to testing. Note: Urine specimens and all materials coming in contact with them should be handled and disposed of as if capable of transmitting infection. Avoid contact with skin by wearing gloves and proper laboratory attire. Do not open pouches until ready to perform the assay. Remove the protective cap form the test device and hold the absorbent strips into the urine sample for at least 10 seconds. Be aware that the urine does not come into contact with the part of the test that is marked with MAX. If the urine comes into direct contact with the open test window, the test gets invalid. Only remove the test strips out of the urine sample when you can see a control line at every single parameter. At least wait till you can see red color on every test window. This assures that enough urine has been absorbed for the correct performance of the test. The line in the test region T is the drug probe line; the line on the control region C is the control line, which is used to indicate proper performance of the device. The color intensity of the test line may be weaker or stronger than that of the control line. The above information is just for reference. The actual technical specifications are subject to the insert provided with the product. Toggle navigation. The following drug types can be detected with the test:. This assay provides only a preliminary analytical test result. Clinical consideration and professional judgement should be applied to any drug of abuse test result, particularly when preliminary positive results are indicated. The assay should not be used without proper supervision and is not intended for over the counter sales to lay persons. It is only for professional use. Urine based screening tests for drugs of abuse range from simple immunoassay tests to complex analytical procedures. The speed and sensitivity of immunoassays have made them the most widely accepted method for screening urine for drugs of abuse. The following drugs are detected with this test:. They are usually taken orally, intravenously, or by smoking. Amphetamines are readily absorbed from the gastrointestinal tract and are then either deactivated by the liver or excreted unchanged in the urine. Amphetamines increase the heart rate and blood pressure and suppress the appetite. Some studies indicate that heavy abuse may result in permanent damage to certain essential nerve structures in the brain. The Drug Screen AMP is based on the principle of the highly specific immunochemical reactions of antigens and antibodies which are used for the analysis of specific compounds in biological fluids. Barbiturates are a class of central nervous system depressants. Phenobarbital is a long acting barbiturate derivative that has been used as a daytime sedative and very extensively as an anti-convulsant. Pentobarbital and Secobarbital are two examples of short acting barbiturate sedatives. Abuse of barbiturates can lead not only to respiratory collapse, coma and even death. Barbiturates are taken orally, rectally, or by intravenous and intramuscular injection. Short acting barbiturates will generally be excreted in urine as metabolites, while the long-acting barbiturates will primarily appear unchanged. The Drug Screen BAR is based on the principle of the highly specific immunochemical reactions of antigens and antibodies which are used for the analysis of specific compounds in biological fluids. Benzodiazepines are the most widely used anxialytic drugs. They are used extensively as anti-anxiety agents, hypnotics, muscle relaxants and anti-convulsants. They are taken orally or sometimes by injection. Benzodiazepines are metabolized in the liver. Some metabolites of benzodiazepines also exhibit pharmacological activities. Benzodiazepines and metabolites are excreted into the urine. Their use can result in drowsiness and confusion. Benzo-diazepines potentiate alcohol and other CNS depressants. Psychological and physical dependence on benzodiazepines can develop if high doses of the drug are given over a prolonged period. The Drug Screen BZO is based on the principle of the highly specific immunochemical reactions of antigens and antibodies which are used for the analysis of specific compounds in biological fluids. Derived from leaves of coca plant, cocaine is a potent central nervous system stimulant and a local anesthetic. Among the psychological effects induced by using cocaine are euphoria, confidence and a sense of increased energy, accompanied by increased heart rate, dilation of the pupils, fever, tremors and sweating. Cocaine is excreted in urine primarily as benzoylecgonine in a short period of time. Benzoylecgonine has a biological half-life of 5 to 8 hours, which is much longer than that of cocaine 0. The Drug Screen COC is based on the principle of the highly specific immunochemical reactions of antigens and antibodies which are used for the analysis of specific compounds in biological fluids. This test is a rapid, visual, competitive immunoassay that can be used for the qualitative detection of benzoylecgonine, the major metabolite of cocaine, in human urine. Marijuana is a hallucinogenic agent derived from the flowering portion of the hemp plant. Higher doses used by abusers produce central nervous system effects, altered mood and sensory perceptions, loss of co-ordination, impaired short-term memory, anxiety, paranoia, depression, confusion, hallucinations and increased heart rate. A tolerance to the cardiac and psychotropic effects can occur, and withdrawal syndrome produces restlessness, insomnia, anorexia and nausea. When marijuana is ingested, the drug is metabolised by the liver. The Drug Screen THC is based on the principle of the highly specific immunochemical reaction of antigens and antibodies which are used for the analysis of specific compounds in biological fluids. Methadone is a synthetic analgesic drug that is originally used in the treatment of narcotic addicts. Among the psychological effects induced by using methadone are analgesia, sedation and respi-ratory depression. Overdose of methadone may cause coma or even death. It is administered orally or intravenously and is metabolized in the liver. The kidneys are a major route of methadone excretion. Methadone has a biological half-life of hours. The Drug Screen MTD is based on the principle of the highly specific immunochemical reactions of antigens and antibodies which are used for the analysis of specific compounds in biological fluids. This test is a rapid, visual, competitive immunoassay that can be used for the qualitative detection of methadone in human urine. Methamphetamine, amphetamine, and metabolites are potent sympathomimetic agents. Acute higher doses lead to enhanced stimulation of the central nervous system and include euphoria, alertness, and a sense of increased energy and power. More acute responses produce anxiety, paranoia, psychotic behavior, and cardiac dysrhythmias. The pattern of psychosis which may appear at high doses may be indistinguishable from schizophrenia. Methamphetamine is excreted in urine as amphetamine and oxidized as deaminated and hydroxylated derivatives. Thus the presence of the parent compound in the urine indicates methamphetamine use. The Drug Screen M-AMP is based on the principle of the highly specific immunochemical reactions of antigens and antibodies which are used for the analysis of specific compounds in biological fluids. The opiates such as heroin, morphine, and codeine are derived from the resin of opium poppy. Heroin is quickly metabolized to morphine. Thus, morphine and morphine glucuronide might both be found in the urine of a person who has taken only heroin. The body also changes codeine to morphine. The Drug Screen MOR is based on the principle of the highly specific immunochemical reactions of antigens and antibodies which are used for the analysis of specific compounds in biological fluids. They have addictive effects leading to substance abuse. They may induce alertness, increased energy, reduced hunger and overall feeling of well being. Ecstasy ECTSASY appear in the urine within three hours after administration any type and be present for hours after the last dose 2,3,4. Tricyclic antidepressants, commonly called TCAs have been prescribed since the s for depression. They are the oldest antidepressants we use today. Until recently TCAs were the clear first choice of physicians for the vast majority of people with major depressive disorder. TCAs work by raising the levels of serotonin and norepinephrine in the brain by slowing the rate of reuptake, or reabsorption, by nerve cells. It may take several weeks to see the desired result. Tricyclic antidepressant TCA overdose remains the leading cause of death from intentional drug overdose. Cardiac arrhythmias and hypotension are the major contributors of death in TCA overdose. Much of the cardiotoxicity from TCAs results from quinidine-like actions on the cardiac action potential and a negative inotropic action. Glucagon has been shown to reverse the depression in cardiac contractility, blood pressure and heart rate in quinidine toxicity. The Drug Screen TCA is based on the principle of the highly specific immunochemical reactions of antigens and antibodies which are used for the analysis of specific compounds in biological fluids. Read the results after 10 minutes or at the latest after 15 minutes as follows:. Two colored lines appear in the viewing window. Only one colored line appears in the control region C. The absence of a test line indicates a positive result. Not all parameters have to be positive at the same time in one test. Please look at every parameter individually. If no line appears in the control region, the test or rather the respective parameter is invalid and should be repeated. A very faint line in the test region indicates that the respective drug in the sample is near the cut-off level of the test. These samples should be re-tested or confirmed with a more specific method before a positive determination is made. If only one parameter e. BZO does not show a control line, you only have to retest the respective parameter with a single test. There is a possibility that technical or procedural errors as well as other substances and factors not listed may interfere with the test and cause false results. If it is suspected that the samples have been mislabeled or tampered with, a new specimen should be collected and the test should be repeated. Good laboratory practice recommends the use of control materials to ensure proper kit performance. Quality control specimens are available from commercial sources. When testing the positive and negative controls, use the same assay procedure as with a urine specimen. We obtained for every single parameter about 60 positive urine samples from clinical laboratories. Furthermore, negative urine samples have been tested. The following results have been obtained:. The accuracy was determined by spiking. The specificity for the Drug Screen Multi 10 Device Test was tested by adding various drugs, drug metabolites, and other compounds that are likely to be present in urine. All compounds were prepared in drug-free normal human urine. Allobarbital 1, Barbital Butalbital 2, Butethal MDMA 1, MAMP 1, MDA 3, Nortriptylin 1. Amitriptylin 1. Imipramin Nordoxepin 1. Doxepin 3. Protriptylin 2. Perphenazin Promazin Trimipramin 2. With exception of the above, for the respective parameter listed positive-reacting drugs resp. Methanol Methaqualone. Orphenadrine Oxalic acid. Pentazocine Penicillin-G. Phenothiazine Phenelzine. Pheniramine L-Phenylephrine. Primidone Promethazine. Procaine 2-Propylantan-acid. Pseudoephedrine d-Propoxyphene. Quinidine Quinine. Riboflavine Salicylic acid. Tenocyclidine Theophylline. Thioridazine cis-Thiothixen. Aniline O. CRC Crit. Toxicol, , 10, Baselt, R. Disposition of Toxic Drugs and Chemicals in Man. Biomedical Publications, Davis, CA, Ellenhorn, M. Medical Toxicology. Elsevier Science Publishing Company, Inc. Gilman, A. The Pharmacological Basis of Therapeutics, eds. Gorodetzkym, C. Greenblatt, D. Benxodiazepines in Clinical Practice. New York: Raven Press, Harvey, R. Lippincotts Illustrated Reviews. Hofmann F. McBay, A. Search for:. Recent Posts. Recent Comments. Copyright Lab Reagent. Barbiturate: Barbiturates are a class of central nervous system depressants. Benzodiazepines: Benzodiazepines are the most widely used anxialytic drugs. Methadone: Methadone is a synthetic analgesic drug that is originally used in the treatment of narcotic addicts. Methamphetamine: Methamphetamine, amphetamine, and metabolites are potent sympathomimetic agents. Tricyclic Antidepressants: Tricyclic antidepressants, commonly called TCAs have been prescribed since the s for depression. Positive: Only one colored line appears in the control region C. Important Note: Not all parameters have to be positive at the same time in one test. Invalid: If no line appears in the control region, the test or rather the respective parameter is invalid and should be repeated. Note: A very faint line in the test region indicates that the respective drug in the sample is near the cut-off level of the test. The assay is designed for use with human urine only.

ACCU-TELL MULTI-DRUG URINE TEST (CE)

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