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Since , it has been operating a site at DESY, seeking to answer research questions using high-intensity X-rays. The results should help to design more effective drugs, develop new vaccines more quickly and facilitate the tailoring of enzymes. Enzymes that are able to break down plastic waste, for example. The method is also useful in biotechnology: it reveals the shape and mobility of enzymes. Based on this, it is possible to understand them and tailor them to make efficient biocatalysts for industry. Furthermore, a method that has been continuously refined by EMBL for several years now also stands to benefit: X-ray imaging can be performed with a high sample throughput while imaging tissues or organisms at a cellular resolution. The technique is already helping scientists to better understand the life cycle of the pathogen that causes malaria and thus to identify new drug targets in the long term. It is also possible to observe the effects of pollutants and climate-related temperature increases on certain marine organisms. These can be used to deliver vaccines, making them a prerequisite for developing and deploying modern mRNA vaccines. With this technique, proteins do not have to be forced into crystalline form, but can be studied in solution, corresponding more closely to their natural state. Changes in the solution — such as salinity, pH value or temperature — may lead to changes in the molecular structure which can be observed with the help of small-angle X-ray scattering. These observations are crucial to understanding the function of the molecule. The technique is not limited to proteins. In future, for example, a robot will use a laser to cut out the pre-grown protein crystals on the beamline and place them in the sample holder. Thanks to a special modification of the new accelerator ring, all three beamlines can continue to operate in their current positions. This means that the laboratories for sample preparation and crystal growth can also stay where they are — an invaluable benefit. Protein crystallography provides an important basis for developing new pharmaceuticals. Researchers who want to study changes in their protein crystals scan microcrystals on so-called chips picture above. PETRA IV promises significant advances in protein crystallography The new facility will allow more experiments to be carried out at high energies, leading to a high resolution. Even the individual hydrogen atoms in a protein can be identified. The more narrowly focused beam can improve the measurement of small protein crystals — which is important when studying enzyme reactions, for example. The higher-intensity beam means that measurements can be performed with a higher temporal resolution. This makes it possible to track how proteins respond to increases in temperature, light or substances, thereby allowing a fourth dimension to be studied. These lead to less radiation damage, especially in small crystals, thereby making it easier to measure properties under lifelike conditions. EMBL beamline P The reactions of proteins to light, temperature or small molecules are investigated in a time-resolved manner in collaboration with the university of Hamburg. PETRA IV will permit even more precise measurements Expanded possibilities: The biomolecules to be studied can be analysed under different conditions at lower concentrations and in a shorter time. Increased precision: The intense X-ray beam allows very dilute samples to be analysed. Real-time observations: The excellent properties of the beam facilitate time-resolved measurements with a sub-millisecond resolution, making it possible to observe how different biomolecules react with each other. Innovative 3D X-ray microscope for much more detailed images The coherence of the radiation is greater, making it more like a laser. This is favourable for capturing extremely high-contrast images. In the future, data from weakly absorbing and unstained samples will provide better image quality and allow samples to be viewed in greater detail. The goal is to increasingly combine different imaging techniques and to also use the high-resolution X-ray imaging at neighbouring beamlines for this purpose. That way it will be possible to zoom in on a section of the image after having obtained an overview of the sample. The robotic arm MARVIN is part of the Crystal Harvester, which cuts crystals from sample plates and automatically mounts them in sample holders under liquid nitrogen. EMBL intends to use the two-year conversion to PETRA IV to optimise its beamlines and fit them with state-of-the-art technology, which is essential in order to remain competitive with other synchrotrons in the long term. FAQs glossary. Further research topics. Healthcare How can diseases be better tackled? New materials How can we save resources? Energy How can we make more resilient materials? New technologies What do we need for the digital world of tomorrow? Earth and the environment How do we preserve our ecosystems? Cultural heritage How can we preserve our cultural treasures? Zum Seitenanfang.

‘A little hyped up’: experts downplay claims over Petra archaeological find

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Researchers urge caution after Jordan tomb excavation and say new clues about Nabataean culture may lie elsewhere. What exactly were their origins? How did their society operate? And why did they hand-carve such spectacular monuments into the reddish rock of the Jordanian desert? Described by the team behind it as like finding the holy grail of Petra archaeology, a large tomb has been excavated immediately in front of the Khazneh, or treasury, the most celebrated of its magnificent facades. Inside were 12 bodies and a range of grave goods, reportedly made from bronze, iron and pottery. The Nabataeans were an Arab tribe whose origins are still debated, but who rose to wealth and power in the centuries before the Christian era thanks to their position on the trading routes of valuable aromatics such as frankincense and myrrh from the Arabian peninsula to the Mediterranean. At the peak of the Nabataean civilisation, their power stretched from Damascus to northern Arabia. Hegra , in present Saudi Arabia, where Wadeson is a research consultant, is another important Nabataean archaeological site. Wadeson said the classical-style architecture at Petra, the Nabataean capital, drew on these extensive cultural connections, but while they were certainly a literate culture, they left very few written records. So our ancient textual sources about them are often in-passing comments from Greeks and Romans. Even tomb inscriptions are rare in Petra, she said, although some at Hegra have offered intriguing suggestions of a very different society to their contemporaries, in which women could own property and may have had real power. Were they sacred courtesans in the temple? Papyri, for example, might still remain. This kind of evidence could still be discovered. View image in fullscreen. Reuse this content. Most viewed.

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