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This is a HealthLine Online content page created by Healthwise. HealthLine Online helps you make better decisions about your health. Cocaine is a powerful stimulant. It is also called coke, snow, C, flake, or blow. It may be mixed cut with other substances, such as cornstarch, talcum powder, or sugar. It may also contain other drugs, such as fentanyl, procaine, or amphetamine. Small amounts of cocaine make a person feel euphoric, energetic, talkative, and mentally alert. It also decreases appetite and the need for sleep. Some people use cocaine and alcohol together, which can cause stronger, longer-lasting effects. When large amounts of cocaine are taken, the high is more intense. But large doses can cause strange or violent behaviour. For example, the person may have tremors or muscle twitches or become paranoid. After using cocaine, the person feels irritable, tired, and depressed. This is called a coke crash. If a person takes the drug at higher and higher doses a binge , they can get more and more irritable, restless, and paranoid. This can cause a person to hear or see things that aren't there hallucinations. Use of cocaine can lead to serious health problems. They include:. Sometimes sudden death can occur, even with the first use of cocaine. Sudden death from cocaine use may occur because of a heart attack or seizure in which breathing stops. Sudden death is more likely to occur when cocaine is used along with alcohol. The effects of cocaine last about 1 to 2 hours. Cocaine can be detected in a urine drug screen up to 6 days after it has been taken. Signs that a person may be using cocaine include:. Author: Ignite Healthwise, LLC Staff Clinical Review Board All Healthwise education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals. Clinical Review Board All Healthwise education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals. This information does not replace the advice of a doctor. Ignite Healthwise, LLC, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content. If you have questions about your health, dial on your phone or visit HealthLine Online. Home Your Health Cocaine. Top of the page. Overview Cocaine is a powerful stimulant. Two forms of cocaine are: The white powder form. It can be sniffed through the nose snorted or dissolved in water and injected in a vein intravenous, or I. It can also be taken by mouth or rubbed onto the gums. The rock crystal, or freebase, form. It can be smoked. Freebase cocaine is called crack, chips, chunks, or rocks. They include: Changes in heart rhythm and heart attack. Headache, seizure, and stroke. Loss of smell, persistent runny nose, nosebleeds, hoarseness, and destruction of the nasal separation nasal septum when the drug is snorted. Bowel tissue death. Damage to the kidneys. Serious infections, HIV, hepatitis , or allergic reactions when injected into a vein. Weight loss and poor nutrition from loss of appetite. Developing a stimulant use disorder. Signs of use Signs that a person may be using cocaine include: Having supplies for injecting cocaine. These are called an outfit or rig. It may include syringes, spoons with smoke stains, small pieces of glass, and razor blades. Persistent runny nose and nosebleeds, which may be a sign of snorting cocaine. Going long periods of time without sleeping or eating. Personality changes. Credits Current as of: November 15, Current as of: November 15, Help Information Emergency. If you believe you have an emergency, dial

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Shawna was an editor at The Scientist from through She holds a bachelor's degree in biochemistry from Colorado College and a graduate certificate and science communication from the University of California, Santa Cruz. A study on the skin-patch strategy, which the authors hope could one day lead to a means of treating addiction and preventing overdoses in humans, appears today September 17 in Nature Biomedical Engineering. Humans naturally make an enzyme, butyrylcholinesterase, that breaks down cocaine, but the research team wanted something more powerful for their skin grafts. So they used an enhanced form of the protein that another group had designed , which has 4, times the cocaine-hydrolyzing activity as the original. The University of Chicago researchers used CRISPR to insert a gene for the souped-up protein into skin epidermal stem cells from mice, seeded the cells onto circular, 1-centimeter-across patches of scaffolding, and then transplanted the tissue onto mice addicted to cocaine. But the experiment was a success: two weeks after their transplants, a dose of cocaine that otherwise would have been lethal had no discernible effect on the mice—apparently, the enzyme broke down the drug before much, if any, of it could reach their brains. The patches continued to make the enzyme through the end of the experiment, 10 weeks after transplantation. Usually other drugs are involved as well. I guess the individual would have \[to\] use really really large quantities of cocaine to get effects. Li et al. The Scientist regrets the error. With a built-in supply of a powerful cocaine-chomping enzyme, the transplant might also curb addiction. Shawna Williams. View full profile. Learn about our editorial policies. Register for free to listen to this article. Listen with Speechify. Interested in reading more? Become a Member of. Receive full access to more than 35 years of archives , as well as TS Digest , digital editions of The Scientist , feature stories , and much more! Join for free today Already a member? Login Here. Nanoparticles Breathe New Life into Lungs.

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