Amanda Araujo en double penetration

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Amanda Araujo en double penetration
Home University of Barcelona Department of Physical Chemistry Maria Antonia Egea
University of Barcelona | UB · Department of Physical Chemistry
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Background:
Memantine, drug approved for moderate to severe Alzheimer's disease, has not shown to be fully effective. In order to solve this issue, polylactic-co-glycolic (PLGA) nanoparticles could be a suitable solution to increase drug's action on the target site as well as decrease adverse effects. For these reason, Memantine was loaded in biod...
Purpose:
The main goal of this study was to encapsulate Pioglitazone (PGZ), in biodegradable polymeric nanoparticles as a new strategy for the treatment of ocular inflammatory processes.

Methods:
To improve their biopharmaceutical profile for the treatment of ocular inflammatory disorders, nanospheres (NSs) of PGZ were formulated by factorial de...
Glaucoma is a multifactorial neurodegenerative disease associated with retinal ganglion cells (RGC) loss. Increasing reports of similarities in glaucoma and other neurodegenerative conditions have led to speculation that therapies for brain neurodegenerative disorders may also have potential as glaucoma therapies. Memantine is an N-methyl-d-asparta...
The aim of the present study is to elucidate the neuronal pathways associated to NSAIDs causing a reduction of
the risk and progression of Alzheimer's disease. The research was developed administering the active enantiomer
of ibuprofen, dexibuprofen (DXI), in order to reduce associated gastric toxicity. DXI was administered from three
to six-month-...
Context:
The stabilization of flurbiprofen loaded poly-Ɛ-caprolactone nanoparticles (FB-PƐCL-NPs) for ocular delivery under accurate freeze-drying (FD) process provide the basis for a large-scale production and its commercial development.

Objective:
Optimization of the FD to improve long term stability of ocular administration's FB-PƐCL-NPs Meth...
Dexibuprofen loaded pegylated poly(lactic-co-glycolic) nanospheres prepared by solvent diffusion method were designed to increase Dexibuprofen brain delivery reducing systemic side effects. Nanospheres exhibited a mean particle size around 200 nm (195.4 nm), monomodal population and negative surface charge. Drug loaded nanospheres showed a sustaine...
Cationic lipid nanoparticles (LNs) have been tested for sustained release and site-specific targeting of epigallocatechin gallate (EGCG), a potential polyphenol with improved pharmacological profile for the treatment of ocular pathologies, such as age-related macular edema, diabetic retinopathy, and inflammatory disorders. Cationic EGCG-LNs were pr...
Pranoprofen (PF)-loaded poly (lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) were optimized and characterized as a means of exploring novel formulations to improve the biopharmaceutical profile of this drug. These systems were prepared using the solvent displacement technique, with polyvinyl alcohol (PVA) as a stabilizer. A factorial design wa...
Solid lipid nanoparticles (SLNs) produced from multiple emulsions technology theoretically enclose an inner aqueous compartment suitable for hydrophilic biomolecules. This paper reports a 3(3) full factorial design study to optimize SLNs formulations for hydrophilic biomolecules. The concentrations of solid lipid, lipophilic and hydrophilic emulsif...
Poly(D,L-lactide-co-glycolide) and poly(D,L-lactide-co-glycolide) with poly(ethylene glycol) nanospheres (NSs) incorporating flurbiprofen (FB) were freeze-dried with several cryoprotective agents and sterilized by γ-irradiation. Only when 5.0% (w/v) hydroxypropyl-β-cyclodextrin (HPβCD) was used, a complete resuspension by manual shaking and almost...
Flurbiprofen (FB)-loaded nanostructured lipid carriers (NLCs) based on Compritol®888 ATO (C888; FB-C888NLC) were developed for anti-inflammatory ocular therapy. NLCs prepared by high-pressure homogenization technique following a factorial design had low particle size (<199 nm), high entrapment efficiency (∼90%), and long-term physical stability. Pr...
The suitability of solid lipid nanoparticles (SLN) for the encapsulation of risperidone (RISP), an antipsychotic lipophilic drug, was assessed for oral administration. The hot high pressure homogenization (HPH) and the ultrasound (US) technique were used as production methods for SLN. All the studies on the SLN formulations were done in parallel, i...
A novel nanocarrier based on solid lipid nanoparticles (SLNs) was developed for insulin delivery using a novel double emulsion method. Physical stability of particles was assessed by size analysis using dynamic light scattering (DLS), matrix crystallinity by differential scanning calorimetry (DSC) and toxicity analysis by Drosophila melanogaster te...
Triamcinolone acetonide (TA) is a corticosteroid drug currently administered by intravitreal injection for a broad spectrum of inflammatory, edematous and angiogenic ocular diseases. To increase the drug's bioavailability by ocular instillation, TA was encapsulated in nanostructured lipid carriers (NLC), previously optimized by our group using a fa...
The purpose of this study was to design and optimize a new topical delivery system for ocular administration of flurbiprofen (FB), based on lipid nanoparticles. These particles, called nanostructured lipid carriers (NLC), were composed of a fatty acid (stearic acid (SA)) as the solid lipid and a mixture of Miglyol(®) 812 and castor oil (CO) as the...
The potential use of nanostructured lipid carriers (NLC) composed of a fatty acid [stearic acid (SA)] or a triglyceride (glyceryl behenate) as solid lipids, and a mixture of medium chain triglycerides and castor oil as liquid lipids, for skin administration of flurbiprofen (FB), has been explored. Two different optimized NLC formulations (FB-SANLC...
Packaging small drug molecules, such as non-steroidal anti-inflammatory drugs (NSAIDs) into nanoparticulate systems has been reported as a promising approach to improve the drug's bioavailability, biocompatibility and safety profiles. In the last 20 years, lipid nanoparticles (lipid dispersions) entered the nanoparticulate library as novel carrier...
Due to the multiple barriers imposed by the eye against the penetration of drugs, the ocular delivery and targeting are considered difficult to achieve. A major challenge in ocular drug therapy is to improve the poor bioavailability of topically applied ophthalmic drugs by overcoming the severe constraints imposed by the eye on drug absorption. One...
The need of an enzymatic cleaner for soft contact lens care with an improved ocular safety and stability profile led us to evaluate the use of nanoparticles (NPs) of poly(D,L-lactide-coglycolide) (PLGA) and methyl trypsin (MT). NPs were prepared by double emulsion–solvent evaporation technique. A factorial design was performed to select the lactic...
The purpose of this study was to develop a novel nanostructured lipid carrier (NLC) for the intravitreal-targeting delivery of triamcinolone acetonide (TA) by direct ocular instillation. A five-level central composite rotable design was used to study the influence of four different variables on the physicochemical characteristics of NLCs. The analy...
Dry eye syndrome or the keratoconjunctivitis sicca is a common disease of tear film and ocular surface developed in numerous aetiologies. Tear film instability and ocular surface disturbances that subsequently influence the tear film are among the primarily causes of this disease, but many other factors are involved in tear film disorders. Clinical...
Novel strategies for ocular anti-inflammatory therapies are extensively beinginvestigated to increase drug bioavailability and decrease adverse side effects of commontreatments. Colloidal carriers based on lipid materials are becoming a suitable alternativedue to several advantages, including solubilization of hydrophobic/lipophilic antiinflammator...
Novel strategies for ocular anti-inflammatory therapies are extensively being investigated to increase drug bioavailability and decrease adverse side effects of common treatments. Colloidal carriers based on lipid materials are becoming a suitable alternative due to several advantages, including solubilization of hydrophobic/lipophilic anti-inflamm...
Poly(lactide-co-glycolide) acid (PLGA) nanospheres incorporating flurbiprofen (FB) were produced by the solvent displacement technique, for ocular applications aiming to avoid/minimize inflammation induced by surgical trauma. In this work, a PLGA of low viscosity has been tested and the results obtained were compared with those previously reported...
Unlabelled:
The eyes are among the most readily accessible organs in terms of location in the body, yet drug delivery to eye tissues is particularly problematic. Poor bioavailability of drugs from ocular dosage forms is mainly due to precorneal loss factors (e.g., tear dynamics, nonproductive absorption, transient residence time in the cul-de-sac,...
Poly(D,L-lactide-co-glycolide) nanospheres incorporating flurbiprofen were prepared by the solvent displacement technique for purposes of assessing (i) drug-polymer physicochemical interactions, (ii) flurbiprofen release from the polymer matrix and (iii) eye permeation of the drug formulated in the colloidal system. The resulting nanospheres were o...
Abstract Entrapment of methotrexate in biodegradable colloidal systems was studied. Nanospheres were characterized in terms of morphometrical properties, such as particle diameter and particle size distribution. The ability of two surfactants, and dextrans of different molecular weights to improve the entrapment of the drug in a polymeric matrix wa...
Abstract The physical and chemical properties of tramcinolone acetonide nanocapsules, prepared by interfacial polymerization of isobutyl-2-cyanoacrylate at the oil/water I interface, have been studied. The joint effect of monomer and oil in organic phase on the size and encapsulation efficiency has been analyzed. Polymer coating around the oil drop...
This study reports on the preparation and evaluation of cyclophosphamide loaded-polyalkylcyanoacrylate nanospheres obtained by emulsion polymerization. Characterization by differential scanning calorimetry, infrared spectroscopy and X-ray diffraction can reveal state dispersion of the drug inside the nanospheres. Such information predicts the stabi...
A model of a corneal apparatus for the study of drug permeation across the corneal tissues is evaluated. The instrument was designed to measure drug transport in living rabbit corneas, which are placed hermetically into a chamber, separating it into two compartments (epithelial and endothelial). The device also allows the measurement and recording...
This work is focused on the ex vivo study of corneal permeation of two anti-inflammatory drugs: diclofenac, and flurbiprofen (as a model of hydrophilic and lipophilic drug, respectively) loaded to cyclodextrins or polymeric nanoparticles in order to determine differences in their corneal permeation against free drug or commercial eye drops. These s...
Poly(lactic/glycolic) acid nanoparticles incorporating flurbiprofen (FB) were prepared by the solvent displacement technique using poloxamer 188 as a stabilizer to improve the availability of the drug for the prevention of the inflammation caused by ocular surgery. A 2(3) + star design was applied to investigate the influence of several factors suc...
The influence of four laminin-derived peptides on bilayer organization is studied. Spectroscopic methods applied were based on pyrene fluorescence properties (quenching, I1/I3, and monomer/excimer equilibrium), asymmetric membrane fluorescence (NBD-PE/dithionite), and polarization fluorescence (TMA-DPH). Also, the ability of these peptides to relea...
The effects of different feeding rates on the lipids fatty acid profile of sharpsnout seabream (Diplodus puntazzo) tissues were studied. During a 15-day period, four fish groups were allowed to feed to satiation, at two-thirds and one-third of satiety, and starved, respectively. Reducing food intake progressively increased the n-3:n-6 relationship...
The effect of replacing fishmeal with soybean meal in the diet and also partial dietary protein replacement with carbohydrates, on sharpsnout sea bream (Diplodus puntazzo) total lipid fatty acid profile was studied. A group of sharpsnout sea bream of 200 g were fed a diet containing either 0%, 20%, 40% or 60% of protein from soybean meal. In a seco...
The physical and chemical stabilities of several formulations of cyclophosphamide-loaded polybutylcyanoacrylate (PBCA) nanospheres developed for an ophthalmic application as an immunosuppressive agent were studied over 6 months of storage at 4, 25 and 40 degrees C in different experimental conditions. The physical stability of nanospheres was follo...
A new method for the determination of ibuprofen, non-steroid anti-inflammatory agent, loaded to poly-ε-caprolactone nanospheres was developed and validated by fluorescence spectroscopy. The method was demonstrated to be valid for, precision, accuracy and linearity, being the sensitivity, 7.89 106 mg/ml, adequate for these assays. Results obtained s...
Changes in biological indices (weight, length, gonadosomatic index, condition factor, hepatosomatic index, intraperitoneal fat ratio and fillet portion), and body composition were examined in sharpsnout seabream (30 to 500 g) maintained in culture for one and a half years. Growth was rapid during May–September, and slow from October to April. Gonad...
Four hydrophobic laminin-related peptides and their corresponding parent peptides were synthesized to use them to target liposomes to tumoral cells. The peptide sequence was YIGSR((NH(2))), and hydrophobic residues linked to the alpha-amino terminal end were decanoyl, myristoyl, stearoyl, and cholesteryl-succinoyl. Before use in biological systems,...
The fatty acid composition and lipid content of white muscle, liver and mesenteric fat, in reared v. wild sharpsnout sea bream (Diplodus puntazzo) were compared. The mesenteric fat index fat weight/body weight) and the lipid contents of both white muscle and liver proved consistently higher in farmed v. wild sharpsnout sea bream (79.0 (SE 13.1) v....
In order to improve the rearing conditions and profitability of cultured sharpsnout seabream, it appears essential to learn about this species' feeding demands. As a first step, we have studied sharpsnout seabream nutritional utilization of three commercial diets with different protein/energy (P/E) ratios. Experiments were performed with two fish s...
The physicochemical properties of aceclofenac nanocapsules, prepared by interfacial precipitation of poly-e-caprolactone at the oil/water interface, have been studied. A Central Composite Design was used to investigate the influence of polymerization adjuvants on these properties on the elaboration of aceclofenac-loaded poly-e-caprolactone nanocaps...
The association of an antineoplastic agent, ciclophosphamide, to biodegradable alkylcyanoacrylate nanospheres has been carried out, analysing the effect of several formulation variables, such as, concentration of drug, monomer, superficial active agent and suspending agent in the morphometrical properties by photon correlation spectroscopy. The dru...
In view to their ocular application, aceclofenac loaded nanocapsules were maked using two different polymers, poly-isobutyl-cyanoacrilate and poly-ε-caprolactone. Encapsulation efficiences between 63 and 95%, with mean size between 211 and 377 nm were obtained, depending on the polymer used, the drug and oil (Miglyol®) initial concentrations and th...
A new method for the determination of cyclophosphamide content of polyalkylcyanoacrylate nanoparticles was developed. The analyses were carried out by inductively coupled plasma atomic emission spectrometry (ICP-AES) by measuring the phosphorus content in the drug. The results obtained by this non-selective technique were compared with those given...
The effects of temperature and two different initial pH (2.67 and 7.00) on poly-epsilon-caprolactone (P epsilon CL) nanospheres loaded with flurbiprofen (FB) (aqueous suspensions) were studied to investigate their influence on the stability and physicochemical characteristics of these drug delivery systems. The drug release behavior was also studie...
We report the preparation and evaluation of flurbiprofen loaded-poly-epsilon-caprolactone nanospheres obtained by solvent displacement method. Characterization by thermal methods, infrared spectroscopy and X-ray diffraction analysis can reveal the dispersion state of the drug inside the nanospheres. Such information predicts the stability of the pa...
A new method for the determination of Poloxomer 188 on the flubiprofen poly-ε-caprolactone nanospheres was developed. The analyses were carried out by infrared spectrometry (IRTF). The IRTF method was demonstrated to be valid for sensitivity, precision, accuracy and specificity. Results obtained suggest that the procedure is appropriate for the det...
The association of an antiinflammatory agent, aceclofenac, to biodegradable alkylcyanoacrylate nanocapsules has been carried out, analising the effect of several variables: concentration of drug, Miglyol® 812, Lutrol® F-68, Isobutylcyanoacrylate and pH in the morphometrical properties by photon correlation spectroscopy. The amounts of drug entrappe...
The interactions between flurbiprofen (FB) and different polymers are studied in order to improve the bioavailability of FB. FB-polymer phase diagrams [poly(ethylene glycol) (PEG) 4000, PEG 6000, and poly-epsilon-caprolactone] were constructed and compared with the modeling diagrams. Thermoanalytical methods (differential scanning calorimetry, ther...
The main goal of this work was the study of the association of an antiinflamatory agent, flurbiprofen, to poly-ε-caprolactone nanospheres, analising the stability of these colloidal systems in different pH conditions. The effect of pH and drug concentration in the morphometrical properties and the association efficiency was evaluated by photon corr...
The main goal of this work was the study of the association of an antiinflammatory agent, flurbiprofen, to poly-ξ-caprolactone nanospheres, analising the stability of these colloidal systems in different pH conditions. The effect of pH and drug concentration in the morphometrical properties and the association efficiency was evaluated by photon cor...
In this work cornea lipid model monolayers, at the air–water interface, containing different percentages of cholesterol were developed. The different membrane models were characterized by the compression isotherms, compressibility and area per molecule values. The influence of cholesterol variations on the interaction of flurbiprofen sodium with th...
The association of an antiinflamatory agent, flurbiprofen, to poli-ε-caprolactone nanocapsules has been carried out analising the effect of pH and the concentration of drug in the morphometrical properties by photon correlation spectroscopy. The amounts of drug entrapped into the nanocapsutes has also been evaluated by hight performance liquid chro...
The association of an antiinflammatory agent, flurbiprofen, to poly-ε-caprolactone nanocapsules has been carried out analysing the effect of pH and the concentration of drug in the morphometrical properties by photon correlation spectroscopy. The amounts of drug entrapped into the nanocapsules has also been evaluated by high performance liquid chro...
The synthesis on a solid support of a dodecapeptide containing a HAV-VP2 exposed sequence is described. The surface activity of this p
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