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In microbiology, the Minimum Inhibitory Concentration (MIC) is a test that determines the lowest concentration of a antimicrobial agent needed to inhibit the visible in-vitro growth of a challenge microorganism. To establish the MIC, an antimicrobial agent is incubated across a dilution range with the challenge microorganism typically at a suspension concentration of one million colony forming units (CFU) per milliliter (mL). Growth of the microorganism is determined by turbidity. Test samples exhibiting no antimicrobial activity will be turbid (i.e., cloudy) due to the presence of the microorganism whereas the lack of turbidity indicates that the growth of the challenge microorganism has been inhibited. Once the MIC of an antimicrobial agent is calculated, microorganisms are labeled as susceptible, susceptible-dose dependent (SSD), intermediate, or resistant to the antimicrobial agent.
The MIC test is often taken one step further to determine the Minimum Bactericidal Concentration (MBC) and Minimum Fungicidal Concentration (MFC) of agents. The MBC and MFC refers to the minimum concentration of an antimicrobial agent that reduces the viability of the initial microorganism inoculation by ≥99.9%. In contrast to the MIC that establishes the lowest concentration of antimicrobial agent that inhibits growth, the MBC and MFC identify the lowest concentration of antimicrobial agent that results in death of the microorganism. The MBC and MFC tests have been powerful methods to compare the germ-killing activity of several antimicrobial agents at once, often for screening purposes. In general, if the MBC/MFC is no more than four times the MIC, the antimicrobial agents are regarded as bactericidal/fungicidal. In some cases, the MBC/MFC of an antimicrobial agent is very close to its MIC. If the MBC/MFC of the tested agent against the tested microorganism is ≥ 32 times the MIC, it can be determined that the microorganism has developed resistance to the tested antimicrobial agent.
MIC and MBC/MFB evaluations are typically required in the following circumstances:
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Minimum Bactericidal Concentration (MBC) and Minimum Fungicidal Concentration ( MFC ) assays determine the lowest concentration of an antimicrobial agent required to achieve bactericidal and fungicidal killing, defined as a 99.9% reduction in the initial inoculum.
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The MBC and MFC refers to the minimum concentration of an antimicrobial agent that reduces the viability of the initial microorganism inoculation by ≥99.9%. In contrast to the MIC that establishes the lowest concentration of antimicrobial agent that inhibits growth, the MBC and MFC identify the lowest concentration of antimicrobial agent that results in death of the microorganism.
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The number of agents in Manulife's "Asia Other" segment, which consists of mainland China, Singapore, Vietnam and other emerging markets, fell to 99,567 in the three months ended June 30, from...
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August 11, 2022, 6:42 PM · 2 min read
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TORONTO (Reuters) - Manulife Financial Corp saw the number of agents in its China and Vietnam businesses drop in the second quarter to the lowest since the fourth quarter of 2019, due to increased regulation and lingering pandemic challenges, contributing to a decline in sales in the key region.
The number of agents in Manulife's "Asia Other" segment, which consists of mainland China, Singapore, Vietnam and other emerging markets, fell to 99,567 in the three months ended June 30, from 114,309 in the previous quarter.
These markets accounted for 87% of all agents in Asia.
Talent shortages that have hit most sectors globally have been exacerbated in some markets in Asia - where Manulife, Canada's biggest life insurer, aims to derive half of all core earnings from by 2025 - by local factors including more stringent regulations.
Manulife Asia Chief Executive Damien Green attributed the decline to economic headwinds due to the pandemic, a push to boost the professionalism of agents, and the introduction of new product and sales practice regulations in China.
"We've seen people return to their home provinces to support their families during recent waves of the pandemic," Green added. "But we expect that recruitment will normalize as markets recover."
Canadian rival Sun Life Financial, which also has significant Asian operations, does not disclose agent numbers. Local media have reported that insurers in Asia and Hong Kong were tapping laid off workers in the education, aviation and hospitality sectors for talent to shore up falling sales due to an agent shortage.
On Wednesday, Manulife posted second-quarter core profit that fell to 78 Canadian cents, from 83 cents a year earlier. The decline was driven by largely expected weakness in its global wealth and asset management business, due to equity market declines as well as lower Asia sales.
Despite the challenges, Manulife is confident of meeting its medium-term core earnings growth target of 15% for Asia, Green said. The company has also said it aims to obtain half of its core earnings from Asia by 2025.
Manulife shares fell 1.1% to C$23.93 in morning trading in Toronto, compared with a 0.7% gain in the benchmark Canadian stock index.
"Profitability remains below management's medium-term target," Edward Jones analyst James Shanahan wrote in a note. "Progress relative to (management's) goals would go a long way toward strengthening investor perceptions and driving stronger performance."
(Reporting by Nichola Saminather; Additional reporting by Niket Nishant in Bengaluru; Editing by David Holmes)
An international food crisis exacerbated by the Ukraine war has spurred Canada to boost an over $6 billion annual foreign aid budget to help the most hard-hit countries in Africa and the Middle East, Canada's aid minister said on Thursday. "The Ukraine crisis is creating shock waves when it comes to supply chain and especially food security and impacting the most vulnerable at the most difficult time," said Harjit Sajjan, Canadian Minister of International Development. "We are making adjustments to reflect this ... People are going hungry because the prices of food have gone up," Sajjan told Reuters in an interview in Jordan, the first leg of a regional tour that also takes him to Egypt and Lebanon.
BEIJING (Reuters) -China's factory-gate inflation eased in July to a 17-month low, defying global cost pressures as slower domestic construction weighed on raw material demand, although consumer price increases hit a two-year high as pork supplies tightened. The producer price index (PPI) rose 4.2% year-on-year, the National Bureau of Statistics (NBS) said on Wednesday, versus an uptick of 6.1% in June and analysts' median forecast of 4.8%. China's producer price growth has slowed from a 26-year high in October last year, giving policymakers some leeway to stimulate the flagging economy even as central banks elsewhere scramble to hose down rampant inflation with aggressive interest rate hikes.
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"U.S.-China engagement on climate is sorely needed...to ensure that bilateral tensions do not irreparably harm the ability to reduce emissions"
STORY: China's military has "completed various tasks" around Taiwan but will conduct regular patrols, it said on Wednesday, potentially signaling an end to days of war games but also that Beijing will keep up its pressure on the island.Furious at a visit to Taipei last week by U.S. House Speaker Nancy Pelosi, China had extended its largest-ever exercises around the self-ruled island it claims as its own beyond the four days originally scheduled.Last week's drills included launches of ballistic missiles, some of which flew over the island's capital of Taipei, and simulated sea and air attacks in surrounding skies and waters.
A federal judge ruled Wednesday that Walgreens can be held responsible for contributing to San Francisco's opioid crisis for over-dispensing highly addictive drugs for years without proper oversight and failing to identify and report suspicious orders as required by law. San Francisco City Attorney David Chiu said the pharmacy chain “continually violated what they were required to do under the federal Controlled Substances Act,” failing to track opioid prescriptions, preventing pharmacists from vetting prescriptions and “nor did they see the many red flags of physicians and others who were dramatically over-prescribing.” “Pharmacists were pressured to fill, fill, fill," he said, “and as a result, Walgreens filled our streets with opioids.”
(Bloomberg) -- House Speaker Nancy Pelosi said the US couldn’t let China establish a “new normal” around Taiwan, hours after Beijing announced plans for regular military patrols near the democratically governed island. Most Read from BloombergDozens in China Infected With New ‘Langya’ Virus Carried by ShrewsMedia Tallies Show Extremely Tight Presidency Race: Kenya UpdateMusk Sells Another $6.9 Billion of Tesla Ahead of Twitter TrialUS Inflation Runs Cooler Than Forecast, Easing Pressure on FedCh
Now that Raleigh-Durham International Airport’s London and Paris flights have relaunched, so has the push for additional international service. But what are the most likely destinations?
Let’s talk about electric vehicles (EVs) and their batteries. The high price of gasoline – still up about $2 since President Biden took office – has boosted interest in EVs. Greater customer curiosity will lead naturally to higher demand, and now we get to batteries, and lithium. Lithium is a metallic element essential in the construction of high-voltage battery systems, and every EV built needs an average of 8 kilos of the metal. Industry experts are saying that lithium demand will far outstrip
Among the dozens of stocks to enact splits this year are two industry leaders that scream value and one cash-rich company that's clobbering its shareholders.
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So you'd like to retire a millionaire. Who wouldn't? (Well, maybe billionaires.) In many ways, it all boils down to math: Invest a particular sum (ideally regularly), earn a particular return, and in a particular number of years, you'll get there.
The Senior Citizens League projects the annual cost-of-living adjustment for 2023 to come in at 9.6%, down slightly from the prior month's estimate as inflation cooled a bit.
Quantum computing – the idea that the weird world of quantum mechanics can be harnessed to make faster computers able to solve problems that traditional ones cannot – has always sounded impossibly futuristic. So you may be surprised to hear that you can go on to one computer company’s website and start to use its quantum computers, via the “cloud”, right now.
Persistent supply issues have deflated expectations for the Chinese automaker
(Bloomberg) -- Micron Technology Inc., the leading US maker of memory semiconductors, became the latest chipmaker to declare that demand is falling off rapidly. It warned investors that revenue won’t meet projections, sending industry stocks tumbling.Most Read from BloombergMusk Sells $6.9 Billion of Tesla to Avoid Twitter Fire SaleUK Plans for Blackouts in January in Emergency Energy PlanTrump Under Intense Legal Scrutiny After FBI Searches Mar-a-LagoRussia Is Scouring the Globe for Weapons to
ATCO, AFG and PFLT made it to the Zacks Rank #1 (Strong Buy) income stocks list on August 10, 2022.
Investment research firm New Constructs has added Rivian to its list of “zombie” companies, citing cash as a potential problem for the car maker
(Reuters) -Wednesday's consumer price index report showing U.S. inflation didn't accelerate in July was the first "positive" reading on price pressures since the Federal Reserve began tightening policy, Chicago Fed President Charles Evans said, even as he signaled he believes the Fed has plenty more work to do. With consumer prices unchanged last month compared to June, but up 8.5% from a year earlier, inflation is still "unacceptably" high, and the Fed will likely need to lift its policy rate, currently in the 2.25%-2.5% range, to 3.25%-3.5% this year and to 3.75%-4% by the end of next year, Evans said. The remarks suggest Evans, among the 19 central bankers who set U.S. monetary policy, expects to soon slow what's been the Fed's steepest round of interest-rate hikes in decades.

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