The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.The dietary reference intake established by the Food and Nutrition Board for niacin ranges from 14-18 milligrams niacin daily by mouth for adults, with an upper intake level of 35 milligrams daily by mouth. Niacinamide and niacin are used in cosmetics, as well as hair and skin products. The concentration of niacinamide varies from a low of 0.0001% in night preparations to a high of 3% in body and hand creams, lotions, powders, and sprays. Niacin concentrations range from 0.01% in body and hand creams, lotions, powders, and sprays to 0.1% in paste masks (mud packs).
For age-related macular disease (eye disease), 500 milligrams of immediate-release niacin has been taken by mouth. For preventing clogged arteries, 3,000-4,000 milligrams of niacin has been taken by mouth daily alone or in combination with other cholesterol therapy for 0.5-6.2 years. For heart disease, 0.125-12 grams of niacin has been taken by mouth daily for up to five years. For erectile dysfunction, 500-1,500 milligrams of niacin (Niaspan®) has been taken by mouth for 12 weeks. For high cholesterol, 300-1,2000 milligrams of niacin has been taken by mouth daily for 6-44 weeks as wax-matrix, immediate-release (crystalline); 2 grams of niacin has been injected into the vein over 11 hours. The maximum recommended daily dose is 3 grams. For high cholesterol (in combination with statins or bile acid sequestrants) 500-4,000 milligrams of extended-release or regular niacin has been taken by mouth daily for eight weeks to 6.2 years. Extended-or sustained-release niacin may be started at a dose of 500 milligrams daily and titrated up to 3 grams daily.
For high cholesterol levels in HIV-infected patients 500-2,000 milligrams of extended-release niacin (Niaspan®) has been taken by mouth daily for 44 weeks to two years. For high blood phosphorous levels, a single 375 milligram dose of extended-release nicotinic acid has been taken by mouth. For osteoarthritis, 3 grams of niacinamide has been taken by mouth daily for 12 weeks. For pellagra, or niacin deficiency, 50-1,000 milligrams of niacin has been taken by mouth daily. For skin conditions, 2-5% of niacinamide cream has been applied to the skin for up to 12 weeks. For type 1 diabetes mellitus prevention, 200-3,000 milligrams of niacinamide has been taken by mouth daily for up to one year; 20-40 milligrams per kilogram of niacinamide has been taken daily by mouth for up to one year and lacked evidence of benefit. For type 2 diabetes, 0.5 grams of nicotinamide has been taken by mouth three times daily for six months. There is no proven safe or effective dose for niacin in children.
20-40 milligrams per kilogram has been taken by mouth daily for up to five years, and lacked evidence of benefit.Having enough niacin, or vitamin B3, in the body is important for general good health. As a treatment, higher amounts of niacin can improve cholesterol levels and lower cardiovascular risks. As a cholesterol treatment, niacin has strong evidence. Several studies have shown that it can boost levels of good HDL cholesterol and lower triglycerides as well or better than some prescription drugs. Niacin also modestly lowers bad LDL cholesterol. It's often prescribed in combination with statins for cholesterol control, such as Crestor, Lescol, or Lipitor. However, niacin is only effective as a cholesterol treatment at fairly high doses. These doses could pose risks, such as liver damage, gastrointestinal problems, or glucose intolerance. So don't treat yourself with over-the-counter niacin supplements. Instead, get advice from your health care provider, who can prescribe FDA-approved doses of niacin instead.
Niacin has other benefits. There's good evidence that it helps reduce atherosclerosis, or hardening of the arteries in some people. For people who have already had a heart attack, niacin seems to lower the risk of a second one. In addition, niacin is an FDA-approved treatment for pellagra, a rare condition that develops from niacin deficiency. Niacin has also been studied as a treatment for many other health problems. There's some evidence that it might help lower the risk of Alzheimer's disease, cataracts, osteoarthritis, and type 1 diabetes. However, more research needs to be done.Vitamin B3, also called niacin, is one of the eight B-complex water-soluble vitamins. Niacin has a wide range of uses in the body, helping functions in the digestive system, skin and nervous system. Niacin, a name coined from nicotinic acid vitamin, comes in several forms, including niacinamide (nicotinamide) and inositol hexanicotinate. Each of these forms has various uses as well. Food sources of niacin include yeast, meat, fish, milk, eggs, nuts, green vegetables, beans and enriched breads and cereals.
The human body can also make niacin from the amino acid tryptophan, according to the National Institutes of Health (NIH). Like other B vitamins, niacin helps the body break down carbohydrates, fats and proteins into energy, according to the University of Maryland Medical Center. In addition, it plays a role in gland and liver function. “Niacin has a role in producing certain hormones in the adrenal glands and helps remove harmful chemicals from the liver,” Dr. Sherry Ross, women’s health expert at Providence Saint John’s Health Center in Santa Monica, California, told Live Science. It also can play a part in improving health. According to NIH, it is also used for treating migraine headaches, circulation problems and dizziness, and to reduce the diarrhea associated with cholera. It is also used to lower cholesterol and triglycerides in the blood. The Mayo Clinic reported that niacin can raise HDL (good) cholesterol by more than 30 percent. Some studies have found the taking niacin may help stroke patients.
When rats with ischemic stroke were given niacin, their brains grew new blood vessels, according to researchers at Henry Ford Hospital in Detroit, Michigan. Ischemic stroke is caused by an obstruction within a blood vessel supplying blood to the brain and accounts for 87 percent of all cases. A 2000 study published in the journal Stroke also used rats and found that treatment with nicotinamide may repair damage to the brain caused by strokes. B3 may also be helpful to cancer patients. A recent study found that nicotinamide significantly reduces the incidence of nonmelanoma skin cancers in those with a history of basal cell carcinoma or squamous cell carcinoma. It may be good for other skin conditions, too. In a double-blind trial by the State University of New York, the topical application of a 4 percent niacinamide gel twice a day for two months resulted in a similar acne improvement when compared to 1 percent clindamycin gel. Those who have intimacy problems may also benefit from niacin.
According to a study published in The Journal of Sexual Medicine, vitamin B3 was found to improve the ability to maintain an erection in men with moderate to severe erectile dysfunction. One side effect of taking niacin supplements is mild flushing. Ross described it as a feeling of warmth, itching, redness or a tingly feeling under the skin. The flushing is harmless and usually subsides within one or two hours, according to the British Columbia Drug and Poison Information Center (DPIC). Some over-the-counter niacin tablets deliver the dose in a short burst, which makes the reaction more intense. Timed-release tablets deliver the vitamin more slowly, which reduces the intensity of the flushing. However, this type of niacin may cause liver damage in some people, according to the DPIC. Other side effects can include stomach upset, intestinal gas, dizziness and pain in the mouth, the NIH reported. In the United States and other developed countries, niacin deficiency is rare and is typically found in alcoholics.
According to the University of Maryland Medical Center, symptoms of mild niacin deficiency include fatigue, canker sores, vomiting, depression, poor circulation and indigestion. More severe niacin deficiency can cause a condition called pellagra. The symptoms of pellagra include digestive problems, inflamed or flakey skin, diarrhea and mental impairment. The normal recommended daily allowance (RDA) of niacin is dependent on age, gender, health conditions and reproductive status. For women and men, the average RDA is 14 to 16 milligrams a day, according to the NIH. Those taking medications or those that have medical conditions should contact a medical professional before taking niacin due to drug interactions and side effects. Getting too much niacin is possible, even for healthy individuals. “When taking it, you need to check for interactions with other meds and make sure your labs tests are normal," said Dr. Kristine Arthur, internist at Orange Coast Memorial Medical Center in Fountain Valley, California.