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While 400 IU of vitamin E is more than the recommended dietary allowance for adults, it is not more than the tolerable upper intake level for the vitamin. The amount is generally considered safe and unlikely to cause serious side effects. However, research about the safety of the dosage amounts of vitamin E supplements is ongoing. If you would like more information about the latest research and potential risks associated with your vitamin E dosage, talk to your doctor. Although getting too much vitamin E through food is unlikely to cause any adverse side effects, getting too much through supplements may be dangerous. It is unlikely that taking 400 IU of vitamin E a day through supplementation would cause adverse side effects, but it is possible. Excessive amounts of vitamin E may interrupt blood coagulation and may cause excessive bleeding. Getting too much may also prevent blood platelets from aggregating. Although more research needs to be done, an increased risk of hemorrhagic stroke and even death may also be possible when you get too much of the vitamin through supplementation over an extended period of time.
Generally speaking, keep your vitamin E intake through supplements as close to your recommended dietary allowance amount as possible. This will ensure that you benefit by getting enough of the vitamin but will decrease your chances of experiencing undesirable side effects. The recommended dietary allowance for vitamin E is 15 mg for all people who are 14 years old or older. This is the equivalent to 22.4 IU, which is considerably less than a dose of 400 IU. Talk to your doctor if you believe you may benefit from taking more than the recommended dietary allowance. Getting 400 IU of vitamin E a day is generally considered safe because it is not over the tolerable upper intake level. Getting more than the tolerable upper intake level increases your risk of experiencing unpleasant side effects. The tolerable upper intake level for vitamin E for teenagers between the ages of 14 and 18 is 800 mg, or about 1,200 IU. The tolerable upper intake level for adults over the age of 18 is 1,000 mg, or about 1,500 IU.
Never take more than these amounts unless specifically instructed by a doctor to so. Most people do not experience adverse side effects when taking less than the tolerable upper intake level of a certain vitamin or mineral. However, two meta-analyses of randomized trials have brought up concerns that vitamin E may be unsafe even at doses lower than the tolerable upper intake level, according to the U.S. Office of Dietary Supplements. One of these analyses found that the risk of death began to increase at a dose of just 150 IU a day, while the other analysis found that a dose range of 10 IU to 5,000 IU a day significantly increased mortality risk. It is important to note, however, that the participants in these studies typically had chronic diseases or other risk factors, and the same results may not occur in other healthy adults. In addition, other research reviews have not found evidence that vitamin E supplements increased the risk of mortality in healthy adults. For those concerned about these potential risks, err on the side of caution.
Stick as close to the recommended dietary allowance as possible, and avoid doses of 400 IU of vitamin E a day unless specifically instructed to do so by a doctor. Side Effects of a Vitamin E Supplement Vitamin E Overdose Symptoms Side Effects of Vitamin E Suppositories Weight Loss and Vitamin E Benefits of Vitamin E for Men What Are the Benefits of Amino Acids and Vitamins? Benefits of Vitamin E 400 IU Vitamin E for Vaginal Dryness Recommended Vitamin E Dosage 43 Supplements Exposed: Which Ones to Consider, Which Ones to Avoid How to Use Vitamin E Oil in the Vaginal Area Daily Dose: The Vitamins You Should or Shouldn't Be Taking What Are the Benefits of Vitamin E Regarding Sexual Activity for Men? Side Effects of Vitamin E When Taken With Blood Pressure Medication What is The Best Time to Take Vitamin E? Benefits of Vitamin E SuppositoriesDosing & UsesDosage Forms & Strengths 15 mg PO qDay; not to exceed 1000 mg/day
<18 years: 15 mg PO qDay; not to exceed 800 mg/day >18 years: 15 mg PO qDay; not to exceed 1000 mg/day <18 years: 19 mg PO qDay; not to exceed 800 mg/day >18 years: 19 mg/day PO qDay; not to exceed 1000 mg/day 60-75 units PO qDay 400 units PO twice or four times daily Swallow capsules whole, do not crush or chew Dosage Forms & Strengths Swallow capsules whole, do not crush 1-3 years: 6 mg PO qDay; not to exceed 200 mg/day 3-8 years: 7 mg PO qDay; not to exceed 300 mg/day 8-13 years: 11 mg PO qDay; not to exceed 600 mg/day 13-18 years: 6 mg PO qDay; not to exceed 800 mg/day Cystic Fibrosis Supplementation (Off-label) 1-12 months: 40-50 units/day 1-3 years: 80-150 units/day 4-8 years: 100-200 units/day >8 years: 200-400 units/day InteractionsInteraction CheckerEnter a drug nameNo Results ContraindicatedSerious - Use AlternativeSignificant - Monitor CloselyMinorSeverityName Increased risk of hemorrhagic stroke
Recent evidence suggests that Vitamin E may suppress action of other antioxidants Very modest but statistically significant increase in all-cause mortality with supplemental intake of vitamin E =400 IU/day Hypersensitivity to vitamin E or formulation components Vitamin E, at RDA levels, does not increase bleeding time or affect warfarin except at megadoses (~10x RDA or higher) - adjustment of warfarin may be necessary for such doses Discontinue high dose Vitamin E supplementation 1 month before surgery, may resume after recovery Use with caution in Vitamin K deficiency, bleeding propensity or lesions (bleeding peptic ulcers, hemophilia etc) Vitamin E increases efficacy & decreases toxicity of antineoplastic drugs Pregnancy Category: A (RDA levels) Lactation: Excreted in breast milk; Controlled studies in pregnant women show no evidence of fetal risk.Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.X:Do not use in pregnancy. Risks involved outweigh potential benefits. Sources: Wheat germ oil, sunflower seeds; richest source is vegetable oils Functions: Lipid antioxidant, protects membrane phospholipids, intracellular antioxidant, inhibits platelet aggregationoccurs in premature infants & those who cannot absorb fat; muscle weakness, visceral impairment; infants: anemia, nerve, eye & balance problems that may be permanent Plays a role in protecting red blood cells against hemolysis; has protective effects against free radicals on polyunsaturated fatty acids found in cell membranes; plays a role in preventing oxidation of vitamin A and C Absorption: Reduced in patients with history of malabsorption; water preparations better absorbed than oil preparations