Obes Surg. 2010 Jun;20(6):732-7. Epub 2009 Dec 1.Einarsdóttir K1, Preen DB, Clay TD, Kiely L, Holman CD, Cohen LD.Author information1Centre for Health Services Research, School of Population Health M431, The University of Western Australia, 35 Stirling Highway, Crawley, 6009, Perth, Australia. kristjana.einarsdottir@uwa.edu.auAbstractBACKGROUND: Vitamin D (VitD) deficiency is common following biliopancreatic diversion (BPD). We conducted a prospective open-label study to evaluate the efficacy of a single intramuscular injection with 600,000 IU of cholecalciferol in an arachis oil depot formulation (VitD3, Arachitol Solvay Pharmacia) as an adjunct to regular oral VitD supplementation (Citrical+D) for a period of 12 months following BPD surgery.METHODS: Some 29 patients who had undergone BPD during 2000-2005 were recruited and received a single injection of 600,000 IU of cholecalciferol. Venous blood VitD, parathyroid hormone (PTH), alkaline phosphatase (ALP), ionised calcium and urinary N-telopeptide (NTX) were assessed at baseline and at 1.5, 3, 6, 9 and 12 months post-injection.
Bone mineral density (BMD) was determined at baseline and 12 months post-injection.RESULTS: VitD concentrations (mean +/- SD) were significantly increased from baseline values (61.5 +/- 18.8 nmol/L) at 1.5 months (92.4 +/- 21.5, p < 0.001), 3 months (100.5 +/- 24.4, p < 0.001) and 6 months (79.1 +/- 20.9, p = 0.014) post-injection, with non-significant elevations at 9 months (73.3 +/- 15.1, p = 0.248) and 12 months (73.4 +/- 17.3, p = 0.278). The proportion of patients with 'normalised' VitD levels was significantly higher at all post-injection time points (range, 93-100%) compared with baseline (71.4%; p < 0.01). Ionised calcium and ALP remained within normal levels at baseline and all follow-up time points, although ionised calcium decreased by 3.4% (p = 0.015) and ALP increased by 14.6% (p = 0.021) at 12 months compared with baseline. No significant change in PTH, NTX or BMD was observed.CONCLUSIONS: Intramuscular cholecalciferol injection, as an adjunct to oral supplementation, appears a safe and effective method to increase and maintain VitD levels after BPD.
PMID: 19949888 DOI: 10.1007/s11695-009-0024-3 [Indexed for MEDLINE] Publication typeEvaluation StudiesMeSH termsAdministration, OralAdultAgedAlkaline Phosphatase/bloodBiliopancreatic Diversion/adverse effects*Bone Density/drug effects*Bone Density/physiologyCalcium/bloodCholecalciferol/administration & dosage*Collagen Type I/urineFemaleFollow-Up StudiesHumansInjections, IntramuscularMaleMiddle AgedParathyroid Hormone/bloodPeptides/urineProspective StudiesTreatment OutcomeVitamin D/administration & dosage*Vitamin D Deficiency*/etiologyVitamin D Deficiency*/prevention & controlVitamins/administration & dosage*SubstancesCollagen Type IParathyroid HormonePeptidesVitaminscollagen type I trimeric cross-linked peptideVitamin DCholecalciferolAlkaline PhosphataseCalciumFull Text SourcesSpringerIngenta plcOvid Technologies, Inc.Other Literature SourcesCOS Scholar UniverseMedicalBone Density - MedlinePlus Health InformationVitamin D - MedlinePlus Health InformationMiscellaneousCALCIUM, ELEMENTAL - Hazardous Substances Data BankCHOLECALCIFEROL - Hazardous Substances Data Bank
Please, wait while we are validating your browser June 2010, Volume 20, Issue 6, pp 732–737Effect of a Single ‘Megadose’ Intramuscular Vitamin D (600,000 IU) Injection on Vitamin D Concentrations and Bone Mineral Density Following Biliopancreatic Diversion SurgeryFirst Online: 01 December 2009Received: 01 July 2009Accepted: 30 October 2009DOI: 10.1007/s11695-009-0024-3Cite this article as: Einarsdóttir, K., Preen, D.B., Clay, T.D. et al. OBES SURG (2010) 20: 732. AbstractBackgroundVitamin D (VitD) deficiency is common following biliopancreatic diversion (BPD). We conducted a prospective open-label study to evaluate the efficacy of a single intramuscular injection with 600,000 IU of cholecalciferol in an arachis oil depot formulation (VitD3, Arachitol Solvay Pharmacia) as an adjunct to regular oral VitD supplementation (Citrical+D) for a period of 12 months following BPD surgery.MethodsSome 29 patients who had undergone BPD during 2000–2005 were recruited and received a single injection of 600,000 IU of cholecalciferol.
Venous blood VitD, parathyroid hormone (PTH), alkaline phosphatase (ALP), ionised calcium and urinary N-telopeptide (NTX) were assessed at baseline and at 1.5, 3, 6, 9 and 12 months post-injection. Bone mineral density (BMD) was determined at baseline and 12 months post-injection.ResultsVitD concentrations (mean ± SD) were significantly increased from baseline values (61.5 ± 18.8 nmol/L) at 1.5 months (92.4 ± 21.5, p < 0.001), 3 months (100.5 ± 24.4, p < 0.001) and 6 months (79.1 ± 20.9, p = 0.014) post-injection, with non-significant elevations at 9 months (73.3 ± 15.1, p = 0.248) and 12 months (73.4 ± 17.3, p = 0.278). The proportion of patients with ‘normalised’ VitD levels was significantly higher at all post-injection time points (range, 93–100%) compared with baseline (71.4%; p < 0.01). Ionised calcium and ALP remained within normal levels at baseline and all follow-up time points, although ionised calcium decreased by 3.4% (p = 0.015) and ALP increased by 14.6% (p = 0.021) at 12 months compared with baseline.
ConclusionsIntramuscular cholecalciferol injection, as an adjunct to oral supplementation, appears a safe and effective method to increase and maintain VitD levels after BPD.Click below to see answered questions from other visitors to this page... Taking 50,000 ius vitamin d3 and Still Deficient I have been taking 50,000 ius of vitamin d3 for over a year and I'm still vitamin d deficient. I believe it is at 13. I have been diagnosed with fibromyalgia … Lyme and vitamin d3 I have had a very tough year , west nile first off and then tested positive for Lyme. Some of the naturalpaths and Drs. I have seen have warned against … Liposomal Vitamin D Therapy A new popular fad of liposomal vitamins is really picking up leeway in the natural health arena. And since i am very vitamin D Deficient, it was suggested … Taking Vitamin D in First Trimester of Pregnancy I have been prescribed HuxD3 for a vitamin D deficiency at a dosage of 100,000 iu for 2 days and then a maintenance dose of 20,000 iu a week for another …
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