You are hereHome » Treatments » High Dose Intravenous Vitamin C Infusions High Dose Intravenous Vitamin C InfusionsNaunyn Schmiedebergs Arch Pharmacol. Epub 2013 May 11.Hagel AF1, Layritz CM, Hagel WH, Hagel HJ, Hagel E, Dauth W, Kressel J, Regnet T, Rosenberg A, Neurath MF, Molderings GJ, Raithel M.Author information1Functional Tissue Diagnostics, Department of Medicine I, University Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.AbstractHistamine plays an important role in the development of symptoms in allergic, infectious, neoplastic and other diseases. Empirical findings have suggested beneficial effects of ascorbic acid supplementation in those diseases, and these effects are assumed to be related to a possible decrease in systemic histamine concentration. In the present study, we systematically investigated for the first time the effect of 7.5 g of intravenously administered ascorbic acid on serum histamine levels (as detected by ELISA) in 89 patients (19 with allergic and 70 with infectious diseases).
When all patients were grouped together, there was a significant decline in histamine concentration from 0.83 to 0.57 ng/ml×m2 body surface area (BSA, p<0.0001). The decrease in serum histamine concentration in patients with allergic diseases (1.36 to 0.69 ng/ml×m2 BSA, p=0.0007) was greater than that in patients with infectious diseases (0.73 to 0.56 ng/ml×m2 BSA, p=0.01). Furthermore, the decline in histamine concentration after ascorbic acid administration was positively correlated with the basal, i.e. pre-therapeutic, histamine concentration. Intravenous infusion of ascorbic acid clearly reduced histamine concentrations in serum, and may represent a therapeutic option in patients presenting with symptoms and diseases associated with pathologically increased histamine concentration.PMID: 23666445 DOI: 10.1007/s00210-013-0880-1 [Indexed for MEDLINE] Publication typeControlled Clinical TrialMeSH termsAdultAgedAscorbic Acid/administration & dosage*Communicable Diseases/blood*FemaleHistamine/blood*HumansHypersensitivity/blood*Infusions, IntravenousMaleMiddle AgedYoung AdultSubstancesHistamineAscorbic AcidFull Text SourcesSpringerMedicalAllergy - MedlinePlus Health InformationInfectious Diseases - MedlinePlus Health InformationVitamin C - MedlinePlus Health InformationMiscellaneousSodium ascorbate - Hazardous Substances Data BankL-Ascorbic Acid - Hazardous Substances Data BankHISTAMINE - Hazardous Substances Data Bank
IV therapy is a wonderful way to get a high dose of vitamins, minerals and antioxidants directly into the bloodstream. Thus, the nutrients are rapidly infused into the circulation and are delivered directly into the cellular space without having to go through the digestive tract. Many people notice superior immunity, increased energy and enhanced detoxification from the improvement in cellular health. When cellular health is supported, the body is able to effectively utilize the nutrients supporting the major bodily systems. IV nutrient therapy also provides higher therapeutic doses, when compared to oral supplementation. This method of administration can be life changing for patients with digestive issues or malabsorption, such as in Crohn’s, Ulcerative Colitis or Irritable Bowel Syndrome. IV nutrient therapy is a successful form of treatment for a wide array of health conditions, especially those associated with inflammation, poor immunity, leaky gut or food sensitivities.
Vitalia Natural Medicine offers customized IV formulations to treat a wide array of health conditions, including but not limited to the following: The doctors at Vitalia have received specialized training in IV therapeutics and are pleased to offer the wonderful benefits of IV therapy to our patients. Please contact the office to see if IV therapy is a good fit for you. Scientists have been studying the effects of mega-doses of Vitamin C for decades. Research associated with Vitamin C can be found regarding various cancers, including but not limited to breast cancer, pancreatic cancer, prostate cancer and gastric cancer. This article will review some of the research associated with the use of high dose Vitamin C in cancer treatment. Vitamin C is an essential water-soluble vitamin, also known as ascorbic acid. The antioxidant functions of Vitamin C have been researched extensively to show positive, protective benefits against coronary heart disease, strokes, cataracts, gout, heavy metal toxicities like lead, as well as the prevention of various forms of cancer (1).
For most purposes, oral doses of Vitamin C are adequate to achieve the desired outcome. However, when used adjunctively to treat cancer, Vitamin C must be used intravenously in order to reach doses high enough to have an anti-cancer effect. Hugh D. Riordan, M.D. is one of several pioneers in Vitamin C and cancer research, with 25 years of clinical experience in the administration of over 40,000 onsite high dose IVC treatments. Riordan and his colleagues conducted numerous case studies and discovered that various types of tumor cells were susceptible to destruction from high-dose Vitamin C, when the Vitamin C levels are able to reach 350 to 400 mg/dL in the blood plasma. At this particular dose, Vitamin C becomes a pro-oxidant that is able to selectively induce cellular death of cancer cells, without harm to healthy cells (2). The reason Vitamin C can kill cancer cells is due to research concluding that cancer cells are deficient in an enzyme known as catalase, which is responsible for the breakdown of hydrogen peroxide to water and oxygen.
Therefore, Vitamin C creates a chemical reaction that results in a surge of peroxide free radicals within cancer cells causing them to die. Because normal (non-cancer) cells don’t have a catalase deficiency, they go through the normal process of breaking down the peroxide into water and oxygen, which not only prevents their death, but also actually increases cellular health. Additional research has identified that the role of Vitamin C in cancer treatment, may be inducing cancer cell death through other standard cellular functions and biochemical pathways. Once example of this is the mitochondria, the “powerhouse” energy-producing component of a cell. A recent study in the Journal of Orthomolecular Medicine determined that the mitochondria of cancer cells are inefficient at generating the amount of energy needed to allow for natural cell death (3). However, high doses of Vitamin C optimize health in the sick mitochondria of cancer cells, which allows the cells to do their job at stimulating the immune system and killing cancer cells.
This means that cancer cells are actually too sick and metabolically disabled to die, but when the high-energy mitochondrial burn is restored with Vitamin C, cancer cells are able to undergo a natural cell death. If you are faced with a diagnosis of cancer, treatment options may seem limited to chemotherapy, radiation and/or surgery. However, high dose Vitamin C delivered intravenously can kill early stages of cancer cells and improve quality of life in later stages of cancer. Research has not determined any known contraindications to giving intravenous Vitamin C with any chemotherapy when proper protocol is followed. Furthermore, research is beginning to show that using Vitamin C at the same time of treatment with chemotherapy or radiation may improve the effectiveness of these treatments. In fact, some physicians using high dose Vitamin C recommend giving it on the same day as the chemo or radiation treatments. Research on Vitamin C continues to develop and will ultimately provide greater clarity and insight for it to be accepted as a standard form of conventional cancer treatment.
The current amount of research on high dose Vitamin C, only supports the years of success that doctors and integrative medical establishments have been seeing clinically with their patients. At Vitalia Natural Medicine, you will have a team of doctors overseeing your care. Dr. Wolf devotes a large part of her practice to specializing in adjunctive cancer treatments and will provide comprehensive naturopathic care including diet and nutritional advice and scientifically proven Cancer fighting nutritional supplements. Dr. Wolf specializes in supporting patients through conventional cancer treatment including surgery, chemotherapy and radiation and is specifically trained in drug/nutrient/ herb interactions. She can also answer all of your diet and nutritional questions, and put together a specific nutritional program for you. Both Dr. Minesaki and Dr. Stanclift have extensive experience and specialized training in IV Nutritional therapy. They are certified through the IVNTP (IV Nutritional Therapy for Physicians) to safely administer nutrients intravenously.
The doctor’s at Vitalia work together as a team to provide Comprehensive Naturopathic Care and effective high dose IV Nutritional Therapy including IV vitamin C. What you can expect is a thorough preliminary screening, including blood work to ensure that this treatment is safe for you. Certain individuals with heart or kidney comprise, rare metabolic disorders may not be good candidates. IV Nutritional therapy protocols and treatment schedules can vary depending on the individual, presenting diagnosis and severity of the condition. Patients are started on a low dose of Vitamin C and that amount is increased up to the therapeutic level. Patients are regularly re-evaluated with clinical consultations and necessary blood work and imaging studies to further guide the treatment plan. 3. Mitochondria, Energy and Cancer: The Relationship with Ascorbic Acid Gonzalez MJ, Rosario-Perez G, Guzman AM, Miranda-Massari JR, Duconge J, Lavergne J, Fernandez N, Ortiz N, Quintero del Rio AI, Mikirova NA, Riordan NH, Ricart CM
Orthomolecular Medicine, 2010, 25(1):29-38 ( to find research article) Docetaxel combined with IV Vitamin C shows enhanced benefit: 1. Fromberg, A, et.al. Ascorbate Exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs. Cancer Chemother Pharmacol, 67:1157-1166, 2011. DOI 10.1007/s00280-010-1418-6 (Springer online). Carboplatin combined with IV Vitamin C shows enhanced benefit and outcomes: 1. Sullivan, G. et. Prospective Randomized Phase I/IIa Pilot Trial to Assess Safety and Benefit Administering High Dose Intravenous Ascorbate in Combination with Chemotherapy in Newly Diagnosed Advanced Stage III or Stage IV Ovarian Cancer. Moderated Abstract [6] presented at the Society for Integrative Oncology, Cleveland, OH. 2. Ma, Y. Drisko, J. Poilreddy, K. Synergistic Effects of Ascorbate with Carboplatin against Human Ovarian Cancer in Vitro and in Vivo. Moderated Abstract [20] presented at the Society for Integrative Oncology, Cleveland, OH.