Thank you for your question. First of all, there is no reason to be embarrassed. It is not your fault that you have verruca plana. There is also no reason to be sad, as it is highly curable with the right treatments. In cases involving any type of medical information, Pubmed is aPubmed is a database of studies published in journals and is very helpful for sorting fact from myth. Here are a few studies that have been done on Verruca Plana. "Treatment of verruca plana with 5% 5-fluorouracil ointment" This study found that for patients who did not respond well to treatment with salicylic acid, vitamin A acid, dinitrochlorobenzene (DNCB), carbon dioxide cryotherapy, oral administration of methotrexate or intramuscular injection of sodium cacodylate often responded well to a treatment with 5% 5-fluorouracil ointment. DNCB also worked well in another study involving the same scientists. "Therapeutic effect of dinitrochlorobenzene (DNCB) on verruca plana
International Journal of Dermatology This study from a Chinese journal found that a Vitamin B12 injection was successful in 100% of sufferers' cases. "[The effect of Vit. B12 injection into acupoints in the treatment of Here is a rundown of the various treatments. acid, the other treatments have all been disputed and studies have found that they are no better than placebo. I would stay with salicyclic acid unless it does not help at all. This is the most common treatment for all warts. It is also the most effective and economical treatment that has been found. It is used in a process called keratolysis, and treatments with this ingredient are available over-the-counter at supermarkets and drug stores. the least expensive and most effective treatment for warts. application can prevent recurrence permanently. "Cutaneous warts: an evidence-based approach to therapy" American Family Physician, August 15, 2005 by Rocky Bacelieri,
"The Cochrane review (5) identifies topical therapy with salicylic acid as safe and effective and reports that no clear evidence exists to prove that other therapies have an advantage in regard to higher cure rates or fewer adverse effects. The pooled data from six RCTs demonstrated a cure rate of 75 percent in those treated with salicylic acid compared with 48 percent in the control group. guideline (4) lists salicylic acid as the first-line therapy for flat warts on the face, plantar warts, and flat and common warts on the Prescribed versions of salicyclic acid can have a 70% concentration, as opposed to 17% for over-the-counter versions. The best types of treatments to buy are pads, discs or flexible collodion, which is a liquid that dries to a film. products allow the acid to penetrate deeper and act longer. also some things you can do to help the treatment along. stone to siphon away the dead skin every two days and help get rid of
If the surrounding skin becomes inflamed, you can protect it with petrolatum before adding the salicylic acid. Wikipedia entry: Treatment of warts by keratolysis This involves freezing the surface of the wart until the cells are destroyed. An example of a cryosurgery product is the Histofreezer: Cryosurgery products have not found in studies to be more effective than treatment or placebo, so it is not really clear whether they workIt is best to try proven therapies from scientific studies rather than any form of cryosurgery. "In general, the wart is frozen for 10 to 30 seconds until a 1- to 2-mm iceball halo surrounds the targeted area. (4,6) The highest cure rates are achieved when treatment occurs at a frequency of every two(10,13) Benefit from therapy continuing for more than three months has not been documented..." Many studies disagree on the effectiveness of laser treatment. recommends it as a second-line treatment for the face, while another
says that it should not be used for the face at all. continuation of the above article with more information on this therapy as a treatment: Again, studies disagree on this medicine's effectiveness as wartSome studies say it works, some say it is no better than aIt's a burning treatment that can be applied daily and should be used six times for a verruca. This might not be an option if the warts are on your lips. duct tape therapy-- leaving duct tape over a wart for six days-- has proven to be more effective in studies than cryotherapy, although not as much as salicyclic acid. "Fungal, Bacterial, and Viral Infections of the Skin: Viral Infections" "Liquid nitrogen is a common initial treatment of choice for manyAdministered with a cotton-tipped applicator or cryospray device, liquid nitrogen freezes the lesion, causing it to blister andMore than one application at 2- to 3-week intervals may be necessary for large or periungual warts.
Electrodesiccation and curettage or laser surgery are effective for persistent or recurrent lesions." The biggest myth that I came across in my research is that over the counter salicylic acid is not as effective as more expensive and marketed therapies such as cryotherapy. This seems to be a case where the least expensive treatment is the most effective, which is a rarity NHS Factsheet-- Warts and Verrucas Verruca Plana salicylic acid verruca plana liquid nitrogen If you need any clarification before rating, let me know and I'll be glad to assist you. January 2016, Volume 53, Issue 1, pp 888–894Characterization of vitamin B12 in Dunaliella salinaFirst Online: 02 September 2015Revised: 10 August 2015Accepted: 24 August 2015DOI: 10.1007/s13197-015-2005-yCite this article as: Kumudha, A. & Sarada, R. J Food Sci Technol (2016) 53: 888. AbstractVitamin B12 is one of nature’s complex metabolite which is industrially produced using certain bacteria.
Algae could be an alternative source of vitamin B12 and in this study, vitamin B12 from a halotolerant green alga, Dunaliella salina V-101 was purified and characterized. The extract of Dunaliella was purified by passing through Amberlite XAD-2 and EASI-extract vitamin B12 immunoaffinity column. The total vitamin B12 content in purified sample fractions was 42 ± 2 μg/100 g dry weight as determined by the chemiluminescence method which was almost close to 49 ± 2 μg/100 g dry weight as estimated by microbiological method. Further quantification of total vitamin B12 using gold nanoparticle (AUNPs) based aptamer showed 40 ± 0.8/100 g dry weight. There was a good correlation among all the methods of quantification. Adenosylcobalamin, a form of vitamin B12 which is a cofactor for methylmalonyl CoA mutase was identified by HPLC. Upon quantification, Dunaliella was found to contain 34 ± 4 μg of adenosylcobalamin for 100 g dry biomass. Authenticity of adenosylcobalmin was confirmed by tandem mass spectrometry (MS/MS), selected ion recording (SIR) and multiple reaction monitoring (MRM) studies.