Magnesium and B12 injections are so helpful that it is pointless progressing onto other things without trying these first. Below I set out the options that I see as available to anyone to whom I have recommended these injections. 1. Some GPs are unwilling to prescribe the magnesium and B12 but are prepared to inject them. In this event I can supply the magnesium and B12 (only if you are an existing patient of mine) and the GP's practice nurse should be able to inject. 2. The second possibility is that I teach you to inject yourself (only if you are an existing patient of mine) if the GP refuses to have anything to do with magnesium and B12 injections. This has great advantages because the timing of the magnesium and B12 depends on your clinical symptoms. Some people know exactly how long the injections "last" so that, for example, if they are going through a good phase the effect of the magnesium injection will last longer, whereas if they are going through a bad patch then the effect will last for a shorter time period.
Sometimes more benefit is obtained from the B12 than from the magnesium or vice-versa and the injections can be adjusted accordingly. I can teach you how to inject yourself during a consultation, or alternatively you can be taught by a competent local practitioner such as a doctor or nurse. Many of my patients do end up injecting themselves simply because this saves them the effort of travelling down to their GP's surgery on a regular basis and the risk of picking up nasty infections in the waiting room. 3. The third possibility is that you train yourself to self-inject by following a set of extremely clear and well written instructions on giving a subcutaneous injection and published by the Clinical Center of the National Institutes of Health in Giving a subcutaneous injection. Please see below also for a great tip on how to use Blu Tack to help with these injections if using ampoules! 4. If injections are not for you, for whatever reason, I now have a preparation of B12 which delivers 5,000 mcg (i.e. ten times the dose in a ½ ml injection) as a sublingual spray.
Even with perfect B12 absorption one can only expect 1% to actually get through the gut wall! So, the idea of the sublingual spray is that some is absorbed under the tongue, the so called "first pass effect" whereby the liver is by-passed. It works well for some people, but many CFSs tell me that the injections are irreplaceable! It costs approx £23 for 60 doses (nearly 3 months supply). It is available from my online shop Shot-O-B12 from Sales at Dr Myhill. 5. Another option in this situation is to try delivering magnesium and B12 through the skin. I have very happy feedback from patients using transdermal preparations of both B12 and magnesium – please see 'Transdermal micronutrients Both of these preparations are available from my online shop -- Transdermal B12 spray and Transdermal magnesium chloride spray 6. The final possibility is to try magnesium by nebuliser. This I have been trying for several years now with reasonably good results in some patients - Magnesium by nebuliser
Some of my patients obtain B12 in ampoules and loading a syringe from an ampoule (or "vial") can require the dexterity of a Roman centurion - centurions were chosen, in part, for their ability to throw missiles with both hands equally well (Ref - Vegetius. One of my patients, Jane Scott, has come up with an ingenious solution - "The Blu Tack Solution". Here is her explanation, in her own words, with a picture to the right. You can see the Blu Tack at the base of the ampoule. "Loading B12 into your insulin syringe can be a real pain and very tricky. Especially from the methylcobalamin vials. All hail the wonders of the humble piece of Blu Tack..... I no longer require a third hand to hold the vile vial. My Blu Tack securely holds the B12 vial at whatever angle required to leave my hands free to fill the syringe." In addition, the surface tension of B12 means that it does not run out when you tip the vial at really quite extreme angles. Sarah Myhill Limited :: Registered in England and Wales :: Registration No. 4545198
Registered Office: Upper Weston, Llangunllo, Knighton, Powys, Wales LD7 1SL, UK. Tel 01547 550331 | Does a vitamin B12 injection (Trineurosol HP/HV) taken once daily for ten days, then weekly, for 3 months followed by a monthly dose, have any side effects on patients? The vitamin B12 serum level of the patient is 137, with a reference range of 200 - 835. The patient is a 31-year-old female and has been asked to take a vitamin B12 injection.Vitamin B12 as it exists in food is a very benign substance. Vitamin B12 pharmacological preparations are usually well-tolerated but some people will react to them, although this is rare.Trineurosol contains a version of B12 known as hydroxocobalamine. The most common adverse effect is dicomfort at the injections site. You can read more about it here: HYDROXOCOBALAMIN - INJECTION side effects, medical uses, and drug interactionsVitamin B12 is water-soluble: “When taken in excess, your body eliminates what it doesn’t need,”. So if you’re not deficient, you’re wasting your money.
Most accounts from healthy people swearing by B12 boils down to a good ol’ placebo effect: If you’re told something works wonders, you’ll likely to feel that it does.Vitamin B12 Injections: Do You Need Them?Skip to Main Content Try our beta test site Oral Vitamin B12 Administration for Vitamin B12 Deficiency After Total Gastrectomy Pernicious anemia develops in 50% of total gastrectomized due to gastric cancer patients. Lack of intrinsic factor, which is secreted by parietal cell from stomach wall causes deficiency of cobalamin, which, in final, causes pernicious anemia. Thus, patients who had undergone total gastrectomy needs to be provided externally with cobalamin. Until now, intramuscular injection of cyanocobalamin has been the choice of treatment for cobalamin deficiency, but it has demerits in that it causes discomfort of coming to the hospital to get an injection, and in its high costs. However, in pernicious anemia in old age and absorption disorder patients, it has been reported that oral administration of cobalamin had effect of elevating serum vitamin B12.
Thus, this study was designed to prove the effect of oral administration of vitamin B12 in total gastrectomized patients with cobalamin deficiency. Intervention Model: Single Group AssignmentMasking: Open LabelPrimary Purpose: Treatment Effect of Oral Vitamin B12 Administration for Vitamin B12 Deficiency After Total Gastrectomy Drug Information available for: Genetic and Rare Diseases Information Center resources: Serum vitamin B12 [ Time Frame: 1,2 and 3 months after administration of medicine ] Questionnaire [ Time Frame: 1,2,3 months after administration of medicine ] MCV [ Time Frame: 1,2,3 months after administration of medicine ] Serum Homocysteine [ Time Frame: 1,2,3 months after administration of medicine ] TIBC [ Time Frame: 1,2,3 months after administration of medicine ] Serum iron [ Time Frame: 1,2,3 months after administration of medicine ] Transferrin [ Time Frame: 1,2,3 months after administration of medicine ]
September 2008 (Final data collection date for primary outcome measure) Vitamin B 12 is important for hexane synthesis. Its deficiency causes pernicious anemia and abnormal functioning neurons. It is not synthesized intrinsically, and extrinsic supplement is vital. Vitamin B 12 is known to be abundant in meat and dairies. It is usually absorbed in form of cobalamin and forms a complex with R binder, decomposed in duodenum, again form a complex with intrinsic factor, and finally absorbed in terminal ileum. In this process, intrinsic factor takes a major role, but when total gastrectomized, absorption of cobalamin is impossible theoretically, because intrinsic factor is known to be produced only from mucosa of the stomach. Thus,deficiency of vitamin B 12 develops, which causes clinical symptoms of pernicious anemia and neurological disorders. Total gastrectomy for cure of upper body cancer of stomach is gradually growing in Korea and Japan, and more than 50% of the patients are reported to have deficiency of vitamin B12.
Pernicious anemia and irreversible neurologic disorder can develop, thus supplementing the vitamin is an important treatment for the patient. However, the protocol in supplementation has not been exhibited as yet. Reported as now in Korea, after average six months postoperation, decrease of vitamin B12 was seen, and it is recommended that injection of Actinamide monthly after six months for supplementation should be the protocol for total gastrectomized patient. Intramuscular injection of Actinamide is the choice of treatment for vitamin B12 deficiency for total gastrectomized patient. However, having to visit hospital and the high cost of intramuscular vitamin B12 is a big burden for the patients. Van Walraven et al. from Canada reported in 2001, that when comparing the cost for oral supplementation of vitamin B12 with intramuscular injection, the difference of cost could rise up to 2 billion dollars. Oral supplementation of vitamin B12 is simple to use, can lower the number of hospital visits, and lessen the injection related complications, and thus improve the quality of life of the patient and bring reduction of medical expense.
However, effect of oral supplementation of vitamin B12 has not been studied in Korea. In Japan, Adachi et al. has reported that oral supplementation has effects on total gastrectomized patients, although its mechanism was not known. Studies on oral supplementation of vitamin B12 for total gastrectomized patient are rare, thus this study was aimed to prove the effect of oral vitamin B12 in total gastrectomized patients, and to establish a protocol for postoperation follow up. Ages Eligible for Study: Sexes Eligible for Study: Undergone total gastrectomy for gastric cancer Regular follow up is possible Has diseases other than stomach cancer Patients with other kinds of oral supplementation (multi-vitamins) Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.