Sheep Supplements & Vitamins We stock a wide range of sheep supplements ranging from our best sellers, a Ewe Drink which is a tonic and cordial for exhaustion in ewes after lambing to a Orph Paste for Sheep. a new way to treat Orph with one application. Check out our full range sheep vitamins and sheep supplements below.Targets (6)Enzymes (1)Transporters (5)Biointeractions (11)Get DrugBank to go! The DrugBank app for iOS and Android is coming soon.Sign up to get early access ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. Methionine synthaseKindProteinOrganismHumanPharmacological actionyesActionscofactorGeneral Function:Zinc ion bindingSpecific Function:Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).Gene Name:MTRUniprot ID:Q99707 Molecular Weight:140525.91 DaReferencesStover PJ: Vitamin B12 and older adults.
Curr Opin Clin Nutr Metab Care. Allen LH: Causes of vitamin B12 and folate deficiency. Methylmalonyl-CoA mutase, mitochondrialKindProteinOrganismHumanPharmacological actionyesActionscofactorGeneral Function:Modified amino acid bindingSpecific Function:Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species.Gene Name:MUTUniprot ID:P22033 Molecular Weight:83133.755 DaReferencesWorgan LC, Niles K, Tirone JC, Hofmann A, Verner A, Sammak A, Kucic T, Lepage P, Rosenblatt DS: Spectrum of mutations in mut methylmalonic acidemia and identification of a common Hispanic mutation and haplotype. Brooks AJ, Vlasie M, Banerjee R, Brunold TC: Co-C bond activation in methylmalonyl-CoA mutase by stabilization of the post-homolysis product Co2+ cobalamin. J Am Chem Soc. 2005 Nov 30;127(47):16522-8. Kozlowski PM, Andruniow T, Jarzecki AA, Zgierski MZ, Spiro TG: DFT analysis of co-alkyl and co-adenosyl vibrational modes in B12-cofactors.
Inorg Chem. 2006 Jul 10;45(14):5585-90. Moras E, Hosack A, Watkins D, Rosenblatt DS: Mitochondrial vitamin B12-binding proteins in patients with inborn errors of cobalamin metabolism. Epub 2006 Sep 29. Stover PJ: Vitamin B12 and older adults. Methionine synthase reductaseKindProteinOrganismHumanPharmacological actionunknownActionscofactorGeneral Function:Oxidoreductase activity, oxidizing metal ions, nad or nadp as acceptorSpecific Function:Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary for utilization of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Folate pathway donates methyl groups necessary for cellular methylation and affects different pathways such as DNA meth...Gene Name:MTRRUniprot ID:Q9UBK8 Molecular Weight:80409.22 DaReferencesO'Leary VB, Mills JL, Pangilinan F, Kirke PN, Cox C, Conley M, Weiler A, Peng K, Shane B, Scott JM, Parle-McDermott A, Molloy AM, Brody LC: Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association.
Epub 2005 Mar 17. Gueant-Rodriguez RM, Juilliere Y, Candito M, Adjalla CE, Gibelin P, Herbeth B, Van Obberghen E, Gueant JL: Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population. Miriuka SG, Langman LJ, Evrovski J, Miner SE, D'Mello N, Delgado DH, Wong BY, Ross HJ, Cole DE: Genetic polymorphisms predisposing to hyperhomocysteinemia in cardiac transplant patients. Transpl Int. 2005 Jan;18(1):29-35. Berkun Y, Abou Atta I, Rubinow A, Orbach H, Levartovsky D, Aamar S, Arbel O, Dresner-Pollak R, Friedman G, Ben-Yehuda A: 2756GG genotype of methionine synthase reductase gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis. Epub 2007 Jul 1. [PubMed:17611986 ] van der Linden IJ, den Heijer M, Afman LA, Gellekink H, Vermeulen SH, Kluijtmans LA, Blom HJ: The methionine synthase reductase 66A>G polymorphism is a maternal risk factor for spina bifida.
J Mol Med (Berl). Epub 2006 Oct 6. Methylmalonic aciduria type A protein, mitochondrialKindProteinOrganismHumanPharmacological actionunknownActionscofactorGeneral Function:Hydrolase activitySpecific Function:Probable GTPase. May function as chaperone. May be involved in the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis.Gene Name:MMAAUniprot ID:Q8IVH4 Molecular Weight:46537.865 DaReferencesOverington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Lerner-Ellis JP, Dobson CM, Wai T, Watkins D, Tirone JC, Leclerc D, Dore C, Lepage P, Gravel RA, Rosenblatt DS: Mutations in the MMAA gene in patients with the cblA disorder of vitamin B12 metabolism. Dobson CM, Gradinger A, Longo N, Wu X, Leclerc D, Lerner-Ellis J, Lemieux M, Belair C, Watkins D, Rosenblatt DS, Gravel RA: Homozygous nonsense mutation in the MCEE gene and siRNA suppression of methylmalonyl-CoA epimerase expression: a novel cause of mild methylmalonic aciduria.
Epub 2006 May 11. Methylmalonic aciduria and homocystinuria type C proteinKindProteinOrganismHumanPharmacological actionunknownActionscofactorGeneral Function:Cobalamin bindingSpecific Function:May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12).Gene Name:MMACHCUniprot ID:Q9Y4U1 Molecular Weight:31728.095 DaReferencesChandler RJ, Aswani V, Tsai MS, Falk M, Wehrli N, Stabler S, Allen R, Sedensky M, Kazazian HH, Venditti CP: Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism. Epub 2006 Jul 14. Ben-Omran TI, Wong H, Blaser S, Feigenbaum A: Late-onset cobalamin-C disorder: a challenging diagnosis. Am J Med Genet A. 2007 May 1;143A(9):979-84. Morel CF, Lerner-Ellis JP, Rosenblatt DS: Combined methylmalonic aciduria and homocystinuria (cblC): phenotype-genotype correlations and ethnic-specific observations. Epub 2006 May 22. Lerner-Ellis JP, Tirone JC, Pawelek PD, Dore C, Atkinson JL, Watkins D, Morel CF, Fujiwara TM, Moras E, Hosack AR, Dunbar GV, Antonicka H, Forgetta V, Dobson CM, Leclerc D, Gravel RA, Shoubridge EA, Coulton JW, Lepage P, Rommens JM, Morgan K, Rosenblatt DS: Identification of the gene responsible for methylmalonic aciduria and homocystinuria, cblC type.