Stücker M1, Memmel U, Hoffmann M, Hartung J, Altmeyer P.Author information1Department of Dermatology and Allergology, Ruhr University, Bochum, Germany. M.Struecker@derma.deAbstractBACKGROUND: There are already many effective topical therapies available for use in the treatment of chronic plaque psoriasis. Unfortunately, these treatments are often associated with a rather significant risk of undesirable effects.OBJECTIVE AND METHODS: In this randomized, prospective clinical trial, the effects of the vitamin D(3) analog calcipotriol were evaluated against those of a recently developed vitamin B(12) cream containing avocado oil in an intraindividual right/left-side comparison. The trial population consisted of 13 patients, 10 men and 3 women, with chronic plaque psoriasis. The observation period was 12 weeks; the effects of therapy were assessed on the basis of a PASI score adapted to the right/left-side comparison technique, the subjective evaluations of the investigator and patients and the results of 20-MHz sonography.
RESULTS: There was a more rapid development of beneficial effects with the use of calcipotriol in the initial 8 weeks, although differences in effects were significant only at the time point of therapy week 8 (p < 0.05). After 12 weeks, neither the PASI score nor 20-MHz sonography showed significant differences between the two treatments. While the efficacy of the calcipotriol preparation reached a maximum in the first 4 weeks and then began to subside, the effects of the vitamin B(12) cream containing avocado oil remained at a constant level over the whole observation period. This would indicate that the vitamin B(12) preparation containing avocado oil may be suitable for use in long-term therapy, a hypothesis further supported by the fact that the investigator and the patients assessed the tolerability of the vitamin B(12) cream containing avocado oil as significantly better in comparison with that of calcipotriol.CONCLUSION: The results of this clinical trial provide evidence that the recently developed vitamin B(12) cream containing avocado oil has considerable potential as a well-tolerated, long-term topical therapy of psoriasis.
Copyright 2001 S. Karger AG, BaselPMID: 11586013 [Indexed for MEDLINE] Publication typesClinical TrialComparative StudyRandomized Controlled TrialResearch Support, Non-U.S. Gov'tMeSH termsAdultAgedCalcitriol/adverse effectsCalcitriol/analogs & derivatives*Calcitriol/therapeutic useDermatologic Agents/adverse effectsDermatologic Agents/therapeutic useFemaleHumansMaleMiddle AgedOintmentsPersea*Phytotherapy*Plant Oils/adverse effectsPlant Oils/therapeutic use*Prospective StudiesPruritus/chemically inducedPsoriasis/diagnostic imagingPsoriasis/drug therapy*Psoriasis/pathologySeverity of Illness IndexSkin/drug effectsSkin/pathologyTime FactorsTreatment OutcomeUltrasonographyVitamin B 12/adverse effectsVitamin B 12/therapeutic use*SubstancesDermatologic AgentsOintmentsPlant OilscalcipotrieneCalcitriolVitamin B 12Other Literature SourcesCited by Patents in - The LensMedicalPsoriasis - Genetic AllianceHerbal Medicine - MedlinePlus Health InformationPsoriasis - MedlinePlus Health InformationMiscellaneousCYANOCOBALAMIN - Hazardous Substances Data Bank1,25-DIHYDROXYCHOLECALCIFEROL - Hazardous Substances Data Bank
Sold by Express Health and Fulfilled by Amazon.DetailsMAXASORB BioActive B12 Cream- Methyl Form, Most BioAvailable. More Energy & Feeling… ( FREE Shipping on orders over . DetailsAdvanced Powerful Vitamin D3 Skin Cream | A therapeutic skin formula containing Vitamin B-12 and Avocado oil, a clinically-researched topical combination, along with Aloe Vera and Vitamins D and E.No animals were used to test this product. Shipping Weight: 5.6 ounces (View shipping rates and policies) #73,780 in Health & Personal Care (See Top 100 in Health & Personal Care) in Health & Personal Care > Vitamins & Dietary Supplements > Vitamins > Vitamin B > B12 75 star43%4 star43%3 star14%See all verified purchase reviewsTop Customer ReviewsPepto PinkI'd order it againGreat productFive StarsSeems to work.Great Product for Aging Skin! Life-Flo Vitamin B-12 Skin Cream, 4 Ounce AnuMed Vitamin D3 Cream 10,000 IU 3 Ounces See and discover other items: vitamin b12 Patients: To order certain products, you must first obtain a Practitioner's Referral, then Register or Login.
Practitioners: To order certain products and refer patients, you must first establish a Practitioner Account. B-12 Cream with Avocado Oil Email to a Friend Based on clinically-researched combination of B-12 and avocado oil Also contains Aloe vera and vitamins D and E Use only as directed on the label or by your healthcare practitioner. Cleanse area before applying. Apply twice daily to skin for a minimum of eight weeks for optimal results. Vitamin B-12 provides a pinkish tint to the product; it will not stain skin or clothing. Direction: Use only as directed on the label or by your healthcare practitioner. Ingredients: Purified water, Glycerin, Aloe Vera (Aloe barbadensis) Gel, Caprylic/Capric Triglyceride, Avocado (Persea americana) Oil, Glyceryl Stearate, Cetearyl Glucoside, d-alpha Tocopherol (Vitamin E), Lecithin, Phenoxyethanol, Sodium Bicarbonate, Cyanocobalamin (Vitamin B-12), Allantoin, Calcipotriol (Vitamin D), and Sangre De Grado (Croton Lechleri).
Warning: For external use only. Keep out of reach of children. If iritation, redness, or discomfort occurs, discontinue use and consult a lecensed health care practitioner. No animals were used in the testing of this product. You have no items to compare. Sign up to receive special offers & promotions: Click here to see past ordersDetailsAnuMed Vitamin D3 Cream 10,000 IU 3 Ounces ( FREE Shipping on orders over . Vitamin b-12 combines vitamin b-12 as cyanocobalamin with aloe vera, avocado oil, vitamin e, and sanger de grado. Ideal for sensitive skin fragrance free, this cream helps to regenerate, nourish and moisturize skin while aiding in skin renewal helps soothe dry, itchy, or irritated skin contains vitamin b-12 as cyanocobalamin. 5.9 x 2.4 x 1.6 inches ; UPC: 811491745093 645951573533 885194965027 811867415681 #143,246 in Beauty (See Top 100 in Beauty) in Health & Personal Care > Health Care > Medications & Treatments > Eczema, Psoriasis & Rosacea Care