The requested URL /drugiden/?page_id=26 was not found on this server. Tafluprost (trade names Taflotan by Santen Pharmaceutical and Zioptan by Merck in the US) is a prostaglandin analogue. It is used topically (as eye drops) to control the progression of open-angle glaucoma and in the management of ocular hypertension, alone or in combination with other medication. It reduces intraocular pressure by increasing the outflow of aqueous fluid from the eyes. The most common side effect is conjunctival hyperemia, which occurs in 4 to 20% of patients. Less common side effects include stinging of the eyes, headache, and respiratory infections. Rare side effects are dyspnoea (breathing difficulties), worsening of asthma, and macular oedema. Nonsteroidal anti-inflammatory drugs (NSAIDs) can either reduce or increase the effect of tafluprost.[1] Timolol eye drops, a common kind of glaucoma medication, does not negatively interact with this drug. No interactions with systemic (for example, oral) drugs are expected because tafluprost does not reach relevant concentrations in the bloodstream.
Tafluprost is a prodrug of the active substance, tafluprost acid, a structural and functional analogue of prostaglandin F2α (PGF2α). Tafluprost acid is a selective agonist at the prostaglandin F receptor, increasing outflow of aqueous fluid from the eyes and thus lowering intraocular pressure. Other PGF2α analogues with the same mechanism include latanoprost and travoprost. Tafluprost, as a lipophilic ester, easily penetrates the cornea and is then activated to the carboxylic acid, tafluprost acid. Onset of action is 2 to 4 hours after application, the maximal effect is reached after 12 hours, and ocular pressure remains lowered for at least 24 hours. Tafluprost acid is inactivated by beta oxidation to 1,2-dinortafluprost acid, 1,2,3,4-tetranortafluprost acid, and its lactone, which are subsequently glucuronidated or hydroxylated. The cytochrome P450 liver enzymes play no role in the metabolism. An analogous pathway (at least up to the tetranor-metabolites) has been found for latanoprost and travoprost.
From left to right: tafluprost, tafluprost acid (the active metabolite), 1,2-dinortafluprost acid, 1,2,3,4-tetranortafluprost acid, 1,2,3,4-tetranortafluprost acid lactone[4][5] A tafluprost/timolol combination ophthalmic solution ^ a b c Tafluprost Professional Drug Facts. ^ a b c d e f g ^ a b c d e Oops... the page you are looking for doesn't exist. Click here to return to the homepage or try searching belowWherever you were trying to get to, you've landed here. are all the places you'll want to bookmark if you want the best tools, free advertising resources, and business building sites on the internet... Free Ad Report Member Links Free Ad Report Original Top 15 Tools Image Below To Download A Free Report On How To Why is this medication prescribed? How should this medicine be used? What special precautions should I follow? What should I do if I forget a dose? What side effects can this medication cause? What should I know about storage and disposal of this medication?
What other information should I know? Selenium sulfide, an anti-infective agent, relieves itching and flaking of the scalp and removes the dry, scaly particles that are commonly referred to as dandruff or seborrhea. It is also used to treat tinea versicolor, a fungal infection of the skin.This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.Selenium sulfide comes in a lotion and is usually applied as a shampoo. As a shampoo, selenium sulfide usually is used twice a week for the first 2 weeks and then once a week for 2, 3, or 4 weeks, depending on your response. For skin infections, selenium sulfide usually is applied once a day for 7 days. Follow the directions on the package or on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use selenium sulfide exactly as directed. Do not use more or less of it or use it more often than directed by your doctor.Do not use this medication if your scalp or the skin area to be treated is cut or scratched.
Avoid getting selenium sulfide in your eyes. If the medication gets into your eyes accidentally, rinse them with clear water for several minutes.Do not leave selenium sulfide on your hair, scalp, or skin for long periods (e.g., overnight) because it is irritating. Rinse off all of the lotion.Do not use this medication on children younger than 2 years of age without a doctor's permission.To use the lotion as a shampoo, follow these steps:selenium sulfide may damage it.Wash your hair with ordinary shampoo and rinse it well.Shake the lotion well.Massage 1 to 2 teaspoonsful (5 to 10 mL) of the lotion into your wet scalp.Leave the lotion on your scalp for 2 to 3 minutes.Rinse your scalp three or four times with clean water.Repeat Steps 4, 5, and 6.If you are using selenium sulfide before or after bleaching, tinting, or permanent waving your hair, rinse your hair with cool water for at least 5 minutes after applying selenium sulfide to prevent discolored hair.Wash your hands well and clean under your nails to remove any lotion.
If your doctor tells you to use the lotion on your skin, apply a small amount of water with the lotion to the affected area and massage it to form a lather. Leave the lotion on your skin for 10 minutes; then rinse it thoroughly.Before using selenium sulfide,tell your doctor and pharmacist if you are allergic to selenium sulfide or any other drugs.tell your doctor and pharmacist what prescription and nonprescription medications you are taking, including vitamins.tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using selenium sulfide, call your doctor.Apply the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not apply a double dose to make up for a missed one.Selenium sulfide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: oiliness or dryness of hair and scalphair losshair discolorationIf you experience either of the following symptoms, call your doctor immediately:
scalp irritationskin irritationIf you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.Keep all appointments with your doctor. Selenium sulfide is for external use only. Do not let selenium sulfide get into your eyes, nose, or mouth, and do not swallow it. Do not apply dressings, bandages, cosmetics, lotions, or other skin medications to the area being treated unless your doctor tells you.Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.