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It is strongly discouraged to take large amounts of this substance or to insufflate snort it. Please see this section for more details. Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25I-NBOMe in humans. It had no history of human use before being sold online as a designer drug in It has been associated with many deaths and hospitalizations. Anecdotal reports suggest that this substance may be difficult to use safely due to its highly sensitive dose-response and unpredictable effects. This compound is pharmacologically unique when compared to other psychedelics through its action on serotonin receptors. It is one of the only full agonists for the human 5-HT 2A receptor receptor in existence. The Ki values of the following targets were greater than Ki: The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely if ever occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death. The visual geometry produced by this substance is similar to LSD and can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colorful in scheme, glossy in color, sharp around the edges and equally angular as well as rounded across their corners. In comparison to other more commonly used psychedelics they can be described as significantly more intricate than the visual geometry found within 2C-I and most of the 2C-x family in general as well as completely on par with LSD , Psilocin and DMT at appropriately high dosages. It seems to consistently be able to build up in visual intensity when the user stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it. However, level 4 hallucinatory breakthroughs are reported but very different and inconsistent in comparison to other more commonly used psychedelics such as psilocin , 2C-E and DMT. Anecdotal reports which describe the effects of this compound within our experience index include:. The LD 50 has not yet been determined although it is potentially fatal at heavy dosages. This substance came to media attention in early after a cluster of seven non-fatal overdoses with the drug were reported in or around Richmond, Virginia. A year-old man from Little Rock, Arkansas died in October after taking a liquid drop of the drug nasally at a music festival. He was reported to have consumed caffeinated alcoholic beverages for 'several hours' beforehand. It is unclear what other drugs he may have consumed, as autopsies usually do not test for the presence of research chemicals. A Brazilian year-old died from overdose in April It is strongly recommended that one use harm reduction practices when using this substance. It is most often self-regulating. After that, it takes about 1 week for the tolerance to be reduced to half and 2 weeks to be back at baseline in the absence of further consumption. This dangerous interactions section is a stub. As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it. Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. Retrieved 7 May Entwicklung eines neuen Struktur-Wirkungskonzepts. Craig Malisow, Houston Press, March 13, http: Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5 2 , Misuse of Drugs Act S. The Stationery Office Limited. Retrieved July 5, , from http: Retrieved from ' https: All articles with unsourced statements Articles with unsourced statements Psychoactive substance Research chemical Phenethylamine Psychedelic. Navigation menu Personal tools English Create account Log in. Views Read View source View history. Community Network Youtube Good vibes.

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