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leptitoxThis leads to the other leptitox problem with metabolism boosters, which is your body can have a rebound effect when you go off them, similar to what happens when you stop taking appetite suppressants. Typically, the longer you are on metabolism boosters and the higher dosages you use, the worse your body will react when you stop taking them. Again, this causes many people to regain the weight they lost while taking the supplement. If you use a metabolism booster, the best thing to do is start with a dose that works and then stop taking it immediately when you stop having positive results.