Like what you’re reading? Get FREE updates sent to your inbox.Email* I want to improve my...I want to improve my...WeightEnergyDigestionBrainOverall HealthAll of the AboveI hate spam too. Your email is safe with me.If a person is, or is suspected to be, very vitamin D deficient a loading dose is typically givenEpub 2010 Feb 5. CONCLUSION: The cholecalciferol loading dose required to reach the serum 25-OHD(3) target level of 75 nmol/l can be calculated as follows: dose (IU)=40x(75 - serum 25-OHD(3))xbody weight. CLICK HERE for PDF of the study and equation Equation converted into units of ng and pounds Dose to get ng (in ng and pounds) = 35 x (- serum 25-OHD(3)) x body weight. Typically spread over over 8 weeks A very commonly prescribed loading dose in the US is 50,000 IU per week for 8 weeks, for a total of 400,000 IU Example uses of the equation to achieve 30 ng (on average) Example uses of the equation to achieve ng (on average) There is a HUGE variation in response between individuals for the average (equation)
600,000 vitamin D loading doses – good response to both oral and muscular – Oct 2015 has the following Take vitamin D3 daily or weekly has the following Response to a single dose of 100,000 IU starting at 27 ng/ml, half life is about 50 days Fatigue reduced by a single dose of vitamin D (100,000 IU) – RCT Dec 2016 Vitamin D supplementation for newborns – 400 IU daily vs 50,000 IU dose – RCT Sept 2016 Diabetic neuropathy reduced by injection of 600,000 IU of vitamin D – Feb 2016 Inflammation reduced by a single dose of Vitamin D (200,000 IU) – RCT Jan 2016 PMS reduced by half in girls who had low levels of vitamin D – RCT Dec 2015 Common cause of dizziness (BPPV) treated by several doses of 50,000 IU of vitamin D – 2015, 2016 200,000 IU restored levels in HIV children having low vitamin D - Nov 2014 Single dose (stoss) vitamin D raised levels in 87 percent of Cystic fibrosis patients – RCT March 2013 500,000 IU of vitamin D cut in half the hospital days following a lung failure – RCT 2015
Loading dose of 500,000 IU vitamin D increased hemoglobin in critical illness – RCT April 2015 Clinical trials using a LOT of vitamin D intervention – Jan 2015 Vitamin D deficiency in adolescents, with 300,000 IU loading dose – Nov 2014 ICU survival increased with vitamin D single loading dose - JAMA Sept 2014 Sickle cell vitamin D deficiency corrected with loading dose – July 2014 Neonate loading dose of 30,000 IU vitamin D helped a lot – May 2014 400,000 IU of vitamin D reduced adult pain and improved quality of life – March 2014 Vitamin D loading dose of 1,800,000 IU reduced shinbone tenderness – Feb 2013 Recurrence of child pneumonia delayed by 100000 IU of vitamin D – RCT Oct 2010 300,000 IU loading dose of vitamin D3 stopped gestational diabetes in RCT – Oct 2011 14000 IU vitamin D (50000 twice a week) often stops Sickle Cell pain Grade A recommendations for vitamin D - May 2009 InVita D3 25,000 IU oral solution
Last Updated on eMC 03-Feb-2016 View changes | Consilient Health Ltd Contact details No. 1 Church Road, Richmond upon Thames, Surrey, TW9 2QE, UK+44(0)20 3751 1889Health Problems and D University of Maryland July 2010 Side effects may include: Metal taste in mouth A frequent need to urinate You cannot get too much vitamin D from sunlight, and it would be very hard to get too much from food. Generally, too much vitamin D is a result of taking supplements in too high a dose. People with the following conditions should be careful when considering taking vitamin D supplements: High blood calcium or phosphorus levels If you are currently being treated with any of the following medications, you should not use vitamin D supplements without first talking to your health care provider. Atorvastatin (Lipitor) - Taking vitamin D may reduce the amount of Lipitor absorbed by the body, making it less effective. If you take Lipitor or any statin (drugs used to lower cholesterol), ask your doctor before taking vitamin D.
Calcium channel blockers - Vitamin D may interfere with these medications, used to treat high blood pressure and heart conditions. If you take any of these medications, do not take vitamin D without first asking your doctor. Calcium channel blockers include: Corticosteroids (prednisone) - Taking corticosteroids long-term can cause bone loss leading to osteoporosis. Supplements of calcium and vitamin D can help maintain bone strength. If you take corticosteroids for 6 months or more, ask your doctor about taking a calcium and vitamin D supplement. Digoxin (Lanoxin) - a medication used to treat irregular heart rhythms. Vitamin D improves absorption of calcium, and calcium, in turn, can increase the likelihood of a toxic reaction from this medication. These drugs may raise the amount of vitamin D in the blood: Estrogen - Hormone replacement therapy with estrogen appears to raise vitamin D levels in the blood, which may have a positive effect on calcium and bone strength.
In addition, taking vitamin D supplements along with estrogen replacement therapy (ERT) increases bone mass more than ERT alone. However, this benefit may be lost with the addition of progesterone. Isoniazid (INH) — a medication used to treat tuberculosis. Thiazide — This kind of diuretic (water pills) can increase vitamin D activity and can lead to high calcium levels in the blood. Vitamin D levels may be decreased by the following medications. If you take any of these medications, ask your doctor if you need more vitamin D: Antacids - Taking certain antacids for long periods of time may alter the levels, metabolism, and availability of vitamin D. Anti-seizure medications - these medications include: Bile acid sequestrants - used to lower cholesterol. Rifampin - used to treat tuberculosis Mineral oil - Mineral oil also interferes with absorption of vitamin D. Orlistat (Alli) - a medication used for weight loss that prevents the absorption of fat.
Because of its effect on fat, orlistat may also prevent the absorption of fat-soluble vitamins such as vitamin D. Physicians who prescribe orlistat also add a multivitamin with fat soluble vitamins. Side Effects and Warnings Vitamin D is generally well tolerated in recommended "Adequate Intake (AI)" doses. One study found a greater likelihood of daytime sleepiness for patients given vitamin D analogues. Vitamin D toxicity can result from regular excess intake of this vitamin, and may lead to hypercalcemia and excess bone loss. Individuals at particular risk include those with hyperparathyroidism, kidney disease, sarcoidosis, tuberculosis, or histoplasmosis. Chronic hypercalcemia may lead to serious or even life-threatening complications, and should be managed by a physician. Early symptoms of hypercalcemia may include nausea, vomiting, and anorexia (appetite/weight loss), followed by polyuria (excess urination), polydipsia (excess thirst), weakness, fatigue, somnolence, headache, dry mouth, metallic taste, vertigo, tinnitus (ear ringing), and ataxia (unsteadiness).
Kidney function may become impaired, and metastatic calcifications (calcium deposition in organs throughout the body) may occur, particularly affecting the kidneys. Treatment involves stopping the intake of vitamin D or calcium, and lowering the calcium levels under strict medical supervision, with frequent monitoring of calcium levels. Acidification of urine and corticosteroids may be necessary. Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Hypermagnesemia (high blood magnesium levels) may develop when magnesium-containing antacids are used concurrently with vitamin D, particularly in patients with chronic renal failure.
Decreased vitamin D effects may occur with the use of certain anti-seizure drugs, as they may induce hepatic microsomal enzymes and accelerate the conversion of vitamin D to inactive metabolites. Based on mechanism of action, use of vitamin D and calcium together may alter inflammatory response. Intestinal absorption of vitamin D may be impaired with the use of these agents. Patients on cholestyramine or colestipol should be advised to allow as much time as possible between the ingestion of these drugs and vitamin D. Use of corticosteroids can cause osteoporosis and calcium depletion with long-term administration. This calcium depletion creates a greater need for both supplemental calcium and vitamin D (which is necessary for calcium absorption). Vitamin D should be used with caution in patients taking digoxin, because hypercalcemia (which may result with excess vitamin D use) may precipitate abnormal heart rhythms. Intestinal absorption of vitamin D may be impaired with the use of mineral oil.
Orlistat (an obesity drug) can reduce vitamin D levels. Patients should consider taking a multivitamin with fat-soluble vitamins at least two hours before or after orlistat or at bedtime. Rifampin increases vitamin D metabolism and reduces vitamin D blood levels. The need for vitamin D supplementation with rifampin has not been thoroughly studied, although additional supplementation may be necessary. Stimulant laxatives can reduce dietary vitamin D absorption. Stimulant laxatives should be limited to short-term use if possible. Concurrent administration of thiazide diuretics and vitamin D to hypoparathyroid patients may cause hypercalcemia, which may be transient or may require discontinuation of vitamin D. Examples of thiazide diuretics include chlorothiazide (Diuril®), chlorthalidone (Hygroton®, Thalitone®), hydrochlorothiazide (HCTZ®, Esidrix®, HydroDIURIL®, Ortec®, Microzide®), indapamide (Lozol®), and metolazone (Zaroxolyn®). Interactions with Herbs and Dietary Supplements
Based on mechanism of action, the use of vitamin D and calcium together may alter inflammatory response. Vitamin D should be used with caution in patients taking herbs with similar properties on the heart as digoxin, because hypercalcemia (which may result with excess vitamin D use) may precipitate abnormal heart rhythms. Vitamin D is necessary for calcium absorption. Vitamin D is often included in calcium supplement products. Interactions with Vitamin D category listing has along with related searches Review of vitamin D interaction with drugs – Jan 2014 Drug–Vitamin D Interactions, A Systematic Review – Jan 2013 Is more medication needed with high level of vitamin D – March 2012 See also on the web Average Drug Label Lists Over Whopping 70 Side Effects Mercola June 2011 "In fact, the more commonly prescribed drugs averaged around 100 side effects each . . . Side Effects and Warning for vitamin DLast modified 14 January, 2016 .