Ships with any qualifying order over $25. Ships with any Subscribe & Save delivery. ( Add-on ItemFREE Shipping on orders over . DetailsDoctor's Best High Absorption Magnesium Dietary Supplement, 200 mg per 2 tablets, 240 Tablets ( FREE Shipping on orders over . DetailsDoctor's Best High Absorption Coq10 w/ BioPerine (100 mg), 120 Soft gels ( FREE Shipping on orders over . Best Vitamin D3 (5000IU) - 360 Softgels Vitamin D3 5000 IU Doctor’s Best Vitamin D3 supports healthy bone density and structure as it is required for optimal calcium absorption. More than that, this nutrient enhances and regulates immune function, supports optimal cardiovascular function and enhances cellular function. Vitamin D deficiency is prevalent with more than 75% of Americans deficient in this nutrient. People who live in the northern half of the United States are at a greater risk of being Vitamin D deficient due to a lack of sunlight.* 75% of Americans are deficient in Vitamin D
Why Take Vitamin D3 While best known for its role in helping absorption of calcium, Vitamin D3 has numerous benefits. Over the last several years research has focused on critical functions of this vitamin and the role it plays in most organs and systems of the body. The major source of Vitamin D is sunlight but use of sunscreen, limited time in the sun and skin color are factors that make getting sufficient Vitamin D from the sun challenging. Doctor’s Best uses Vitamin D3 which is more efficient at converting to active Vitamin D in the body.* What is Doctor’s Best Vitamin D3? It is made of D3, the naturally-occurring form of Vitamin D. Research shows that supplemental Vitamin D3 (cholecalciferol) is significantly more efficient at converting to active Vitamin D in the body than Vitamin D2 (ergocalciferol). This makes Vitamin D3 the preferred supplemental form of this nutrient. Recent studies have shown that the RDA for Vitamin D of 600IU daily is woefully inadequate for assuring optimal Vitamin D levels.
Research suggests that a minimum daily intake of 1000IUs or higher doses are needed to ensure levels are optimal enough to promote health.* How does it work? Vitamin D from dietary intake or sun exposure requires two activation steps in the body. The first activation occurs in the liver, while the second activation occurs in the kidneys, allowing for regulation of calcium metabolism. Vitamin D receptors are present throughout the body, in tissue such as the skin, cartilage, heart, prostate, bones and intestines so the second activation step also takes place in local tissues.* Vitamin D plays a role in most organs and systems of the body. It is hormone-like, known to interact with over 200 different genes, and plays a crucial regulatory role as a metabolic activator for a multitude of metabolic processes. It acts as a “molecular switch” by influencing the expression of multiple genes. Therefore activated Vitamin D not only influences bone health, but is involved in supporting the function of the immune system, cardiovascular system, respiratory system and the musculoskeletal system.*
Cannell JJ, Hollis BW. Altern Med Rev 2008;13:6-20. Dietary Supplement Fact Sheet: Vitamin D. Dietary Supplement Fact Sheet [(2009, 2009] from http://ods.od.nih.gov/factsheets/vitamind.asp - en22. Holick MF, Chen TC, Lu Z, Sauter E. J Bone Miner Res 2007;22 Suppl 2:V28-33. van Etten E, Stoffels K, Gysemans C, others. Zittermann A, Koerfer R. Curr Opin Clin Nutr Metab Care 2008;11:752-7. Zittermann A, Frisch S, Berthold HK, others. Am J Clin Nutr 2009;89:1321-7. Scragg RK, Camargo CA, Jr., Simpson RU. Lips P, Hosking D, Lippuner K, others. J Intern Med 2006;260:245-54. Viljakainen HT, Natri AM, Karkkainen M, others. J Bone Miner Res 2006;21:836-44. American Journal of Clinical Nutrition 2004;79:362-371. Vitamin d from dietary intake or sun exposure requires two activation steps in the body. However, vitamin d receptors are present throughout the body, in tissue such as the skin, cartilage, heart, prostate, bones and intestines. Thus, the second activation step also takes place in local tissues.
Recent discoveries have highlighted the important modulatory effects of vitamin d on various cells of the immune system.vitamin d enhances and regulates immune function. It is known that various cells of the immune system, such as t lymphocytes and antigen presenting cells, express the vitamin d receptor on their surface when activated. Recently, it has been found that treatment of these immune cells with vitamin d influences their expression of cytokines, which are chemical messengers of the immune system. The immune modulating effects of vitamin d extend to monocytes and dendritic cells of the immune system as well. Dendritic cells are important antigen-processing cells of the immune system that function to initiate the immune response. Vitamin d may prevent overactivity of the immune response and keep the immune system in a normal healthy state of vigilance.vitamin d supports optimal cardiovascular function. Research has uncovered the role vitamin d plays in supporting cardiac function.
Heart myocytes (cells) express the vitamin d receptor, as do smooth muscle cells of blood vessels. The benefits of vitamin d on the heart are potentially far-reaching. Studies on mice heart cells have shown that vitamin d administration impacts their growth and proliferation. In these cells, vitamin d inhibited the release of a protein that could be detrimental to the function of these cells, displaying cardioprotective properties. It has also been shown that vitamin d has a modulatory effect on heart rhythm. 2.2 x 2.2 x 4.2 inches ; Shipping Weight: 4.8 ounces (View shipping rates and policies) Item model number: 753950002500 #1,306 in Health & Personal Care (See Top 100 in Health & Personal Care) in Health & Personal Care > Vitamins & Dietary Supplements > Vitamins > Vitamin D > D3 Vitamin D, Extra virgin olive oil, softgel capsule (gelatin, glycerin, purified water). Take one capsule daily or as directed by a nutritionally informed physician. Store in a cool dry place.