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Piperacillin /tazobactam is used to treat a wide variety of bacterial infections . It is a penicillin antibiotic. It works by stopping the growth of bacteria.
This medication is given by injection into a vein as directed by your doctor, usually every 6 hours. It should be injected slowly over at least 30 minutes. The dosage is based on your medical condition and response to treatment. For children, the dosage is also based on age and weight .
If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.
If you are using the frozen pre-mixed solution, thaw the container at room temperature or in the refrigerator. If the bag is thawed in the refrigerator, let it sit at room temperature for at least 1 hour before using. Do not thaw by putting in warm/hot water or microwaving. After thawing, shake well and squeeze the container to check for leaks. Discard if the container leaks. Do not re-freeze the solution after thawing.
For the best effect, use this antibiotic at evenly spaced times. To help you remember, use this medication at the same time(s) every day.
Continue to use this medication for the full time prescribed, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.
Tell your doctor if your condition lasts or gets worse.
Nausea , constipation , diarrhea , headache , or trouble sleeping may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding.
This medication may rarely cause a severe intestinal condition due to a bacteria called C. difficile. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: diarrhea that doesn't stop, abdominal or stomach pain /cramping, blood / mucus in your stool.
If you have these symptoms, do not use anti- diarrhea or opioid products because they may make symptoms worse.
Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection . Contact your doctor if you notice white patches in your mouth , a change in vaginal discharge , or other new symptoms.
Get medical help right away if you have any very serious side effects, including: seizures , signs of kidney problems (such as a change in the amount of urine).
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction , including: fever that doesn't go away, new or worsening lymph node swelling , rash , itching /swelling (especially of the face/ tongue /throat), severe dizziness , trouble breathing .
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Before using piperacillin /tazobactam, tell your doctor or pharmacist if you are allergic to it; or to other antibiotics (such as penicillins, cephalosporins); or if you have any other allergies . This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication , tell your doctor or pharmacist your medical history, especially of: cystic fibrosis , kidney disease , seizure disorder.
This medication contains sodium. Consult your doctor or pharmacist if you are on a salt-restricted diet or if you have a condition that could be worsened by an increase in salt intake (such as heart failure , high blood pressure ).
Piperacillin/tazobactam may cause live bacterial vaccines (such as typhoid vaccine ) to not work well. Tell your health care professional that you are using piperacillin/tazobactam before having any immunizations / vaccinations .
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs , nonprescription drugs, and herbal products).
Older adults may be more sensitive to the extra sodium in this medication.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
This medication passes into breast milk in small amounts. Consult your doctor before breast-feeding.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist . Do not start, stop, or change the dosage of any medicines without your doctor's approval.
One product that may interact with this drug is: methotrexate .
This medication may interfere with certain lab tests (including certain urine glucose tests), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing , call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: seizures .
Lab and/or medical tests (such as complete blood count , sodium/ potassium blood levels, kidney / liver function tests ) should be done while you are using this medication . Keep all medical and lab appointments.
It is important to get each dose of this medication as scheduled. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Do not double the dose to catch up.
Consult the product instructions or your pharmacist for storage details. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Select a condition to view a list of medication options
This survey is being conducted by the WebMD marketing sciences department.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
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Bacitracin

Generic Name: bacitracin Brand Name: Bacitracin

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side effects drug center bacitracin (bacitracin) drug

Bacitracin is a prescription medicine used to treat the symptoms of Dermal Infections. Bacitracin may be used alone or with other medications.
Bacitracin belongs to a class of drugs called Antibacterials, Topical.
Bacitracin may cause serious side effects including:
Get medical help right away, if you have any of the symptoms listed above.
The most common side effects of Bacitracin include:
Tell the doctor if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Bacitracin. For more information, ask your doctor or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Bacitracin and other antibacterial drugs, Bacitracin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
Nephrotoxicity: Bacitracin in parenteral (intramuscular) therapy may cause renal failure due to tubular and glomerular necrosis . Its use should be restricted to infants with staphylococcal pneumonia and empyema when due to organisms shown to be susceptible to bacitracin. It should be used only where adequate laboratory facilities are available and when constant supervision of the patient is possible.
Renal function should be carefully determined prior to and daily during therapy. The recommended daily dose should not be exceeded and fluid intake and urinary output should be maintained at proper levels to avoid kidney toxicity. If renal toxicity occurs the drug should be discontinued. The concurrent use of other nephrotoxic drugs, particularly streptomycin, kanamycin, polymyxin B, polymyxin E (colistin), and neomycin should be avoided.
Sterile Bacitracin, USP is an antibiotic for intramuscular administration. Bacitracin is derived from cultures of Bacillus subtilis (Tracey). It is a white to pale buff, hygroscopic powder, odorless or having a slight odor. It is freely soluble in water; insoluble in acetone, chloroform , and ether. While soluble in alcohol, methanol, and glacial acetic acid , there is some insoluble residue. It is precipitated from its solutions and inactivated by many of the heavy metals.
The molecular formula is: C 66 H 103 N 17 O 16 S. Bacitracin is comprised of a polypeptide complex and Bacitracin A is the major component in this complex. The molecular weight of Bacitracin A is 1422.71.
In accordance with the statements in the “ WARNING BOX ”, the use of intramuscular bacitracin is limited to the treatment of
infants with pneumonia and empyema caused by staphylococci shown to be
susceptible to the drug.
To reduce the development of drug-resistant bacteria and
maintain the effectiveness of Bacitracin and other antibacterial drugs,
Bacitracin should be used only to treat or prevent infections that are proven
or strongly suspected to be caused by susceptible bacteria. When culture and
susceptibility information are available, they should be considered in
selecting or modifying antibacterial therapy. In the absence of such data,
local epidemiology and susceptibility patterns may contribute to the empiric
selection of therapy.
TO BE ADMINISTERED INTRAMUSCULARLY ONLY
Infant dose: For infants under 2500 grams—900 units/kg/24
hours in 2 or 3 divided doses. For infants over 2500 grams—1,000 units/kg/24 hours,
in 2 or 3 divided doses. Intramuscular injections of the solution should be
given in the upper outer quadrant of the buttocks, alternating right and left
and avoiding multiple injections in the same region because of the transient
pain following injection.
Should be dissolved in sodium chloride injection
containing 2 percent procaine hydrochloride. The concentration of the
antibiotic in the solution should not be less than 5,000 units per mL or more
than 10,000 units per mL.
Diluents containing parabens should not be used to
reconstitute bacitracin; cloudy solutions and precipitate formation have
occurred.
Reconstitution of the 50,000 unit vial with 9.8 mL of
diluent will result in a concentration of 5,000 units per mL.
Solutions are stable for one week when stored in a
refrigerator 2° to 8°C (36° to 46°F).
Sterile Bacitracin, USP is available in a vial (1's)
containing 50,000 units ( NDC 0009-0233-01) and as a pack of ten vials (10's)
each containing 50,000 units ( NDC 0009-0233-03).
Store the unreconstituted product in a refrigerator 2° to
8°C (36° to 46°F).
Distributed by: Pharmacia & Upjohn Co., Division of
Pfizer Inc., New York 10017. Revised: Dec 2011
Nephrotoxic reactions— Albuminuria ,
cylindruria, azotemia . Rising blood levels without any increase in dosage.
Other reactions— Nausea and vomiting. Pain
at site of injection. Skin rashes.
Included as part of the PRECAUTIONS section.
See “ WARNING BOX ” for precautions in
regard to kidney toxicity associated with intramuscular use of bacitracin.
Clostridium difficile associated diarrhea (CDAD)
has been reported with use of nearly all antibacterial agents and may range in
severity from mild diarrhea to fatal colitis . Treatment with antibacterial
agents alters the normal flora of the colon leading to overgrowth of C.
difficile .
C. difficile produces toxins A and B which
contribute to the development of CDAD. Hypertoxin producing strains of C.
difficile cause increased morbidity and mortality, as these infections can
be refractory to antimicrobial therapy and may require colectomy . CDAD must be considered
in all patients who present with diarrhea following antibiotic use. Careful
medical history is necessary since CDAD has been reported to occur over two
months after the administration of antibacterial agents.
If CDAD is suspected or confirmed, ongoing antibiotic use
not directed against C. difficile may need to be discontinued.
Appropriate fluid and electrolyte management, protein supplementation,
antibiotic treatment of C. difficile , and surgical evaluation should be
instituted as clinically indicated.
Adequate fluid intake should be maintained orally, or if
necessary, by parenteral method.
As with other antibiotics, use of this drug may result in
overgrowth of nonsusceptible organisms, including fungi. If superinfection
occurs, appropriate therapy should be instituted.
Prescribing Bacitracin in the absence of a proven or
strongly suspected bacterial infection or a prophylactic indication is unlikely
to provide benefit to the patient and increases the risk of the development of
drug-resistant bacteria.
There have been reports of anaphylaxis and/or allergic
contact dermatitis in patients exposed to Bacitracin in non-approved
indications.
This drug is contraindicated in those individuals with a
history of previous hypersensitivity or toxic reaction to it.
Bacitracin exerts pronounced antibacterial action in vitro against a variety of gram -positive and a few gram-negative organisms.
However, among systemic diseases, only staphylococcal infections qualify for
consideration of bacitracin therapy. Bacitracin is assayed against a standard
and its activity is expressed in units, 1 mg having a potency of not less than
50 units.
Susceptibility plate testing: If the Kirby-Bauer method
of disk susceptibility is used, a 10 unit bacitracin disk should give a zone of
over 13 mm when tested against a bacitracin-susceptible strain of Staphylococcus
aureus. Absorption of bacitracin following intramuscular injection is rapid and
complete. A dose of 200 or 300 units/kg every 6 hours gives serum levels of 0.2
to 2 mcg/mL in individuals with normal renal function. The drug is excreted
slowly by glomerular filtration. It is widely distributed in all body organs
and is demonstrable in ascitic and pleural fluids after intramuscular
injection.
Patients should be counseled that antibacterial drugs,
including Bacitracin, should only be used to treat bacterial infections. They
do not treat viral infections (e.g., the common cold ). When Bacitracin is
prescribed to treat a bacterial infection, patients should be told that
although it is common to feel better early in the course of therapy, the
medication should be taken exactly as directed. Skipping doses or not
completing the full course of therapy may (1) decrease the effectiveness of the
immediate treatment and (2) increase the likelihood that bacteria will develop
resistance and will not be treatable by Bacitracin or other antibacterial drugs
in the future.
Diarrhea is a common problem caused by antibiotics which
usually ends when the antibiotic is discontinued. Sometimes after starting treatment
with antibiotics, patients can develop watery and bloody stools (with or
without stomach cramps and fever) even as late as two or more months after
having taken the last dose of the antibiotic. If this occurs, patients should
contact their physician as soon as possible.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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