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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. A Publisher Correction to this article was published on 26 September The objective of this study was to investigate self-medication behavior among Chinese adolescents aged 12—18 years and explore the factors associated with whether adolescents prioritize drug efficacy or safety when engaging in self-medication behavior. In , a questionnaire investigation was conducted in the Chinese mainland using a multi-stage sampling approach. After a statistical description, logistic regression was used to analyze the factors associated with considering drug efficacy and safety. The self-medication rate among Chinese adolescents aged 12—18 years was Of these, Regression analysis showed that individuals with better healthcare were more likely to consider drug efficacy an important factor. Additionally, those with a healthier family lifestyle were more likely to prioritize efficacy. When individuals engage in self-medication, those residing in urban areas and possessing advanced preventive health literacy and ample family health resources tend to prioritize drug safety to a greater extent. Conversely, those with higher monthly household incomes and only children exhibit a decreased inclination towards prioritizing safety during self-medication. Self-medication is a frequently observed practice among Chinese adolescents aged 12— Several factors, such as demographic and sociological characteristics, health literacy, and family health status, have been found to be associated with the extent to which adolescents prioritize medication safety and efficacy when engaging in self-medication practices. Higher levels of health literacy and better family health status were positively correlated with considering both the efficacy and safety of drugs as important factors when self-medicating. Self-medication is a widespread practice where individuals choose and use drugs to treat self-diagnosed illnesses or symptoms, or the intermittent or continued use of prescribed drugs for chronic or recurrent diseases or symptoms 1. This phenomenon is widespread among adolescents globally 2 , 3 , 4 , 5. Adolescents frequently opt for over-the-counter OTC drugs for self-medication. OTC drugs are easily accessible without a doctor's prescription and are relatively inexpensive, and can be purchased directly from pharmacies 6. During adolescence, responsibility for healthcare often shifts from parents and caregivers to the adolescents themselves. As they mature, adolescents typically become more autonomous in managing their medication 7. Various factors influence the selection of medication types in self-medication practices among adolescents. These factors impact how adolescents perceive their illnesses and subsequently affect their choice of drugs. Adolescents' characteristics, such as gender, educational level, and socio-economic status, are associated with the frequency of different types of OTC drugs used in self-medication 9. In , a Brazilian study found that girls aged 11 and 15 years 11 declared to take different types of drugs, especially painkillers 12 , and this behavior has begun to expand to younger ages In terms of the properties of the drug, the type, efficacy and safety are usually related to the adolescent's choice of self-medication. Studies showed that OTC analgesics 12 , antipyretics 4 , cough suppressants 14 , antibiotics 3 , and anti-inflammatory drugs 15 were widely used among adolescents. Acetaminophen, which is found in many OTC cough and cold medications, is also widely used by young people as an analgesic for mild pain or fever However, adolescents are more likely to misuse OTC medication due to their wrong drug use cognition and limited medication knowledge, thus increasing significant health risks It is important to note that medication overdoses related to the misuse of common OTC drugs are quite common. A study conducted in Pakistan in found that adolescents between the ages of 12 and 18 accounted for a high number of emergency department visits due to medication overdoses, with acetaminophen, other nonsteroidal anti-inflammatory drugs NSAIDs , and cough medicine being the most common culprits Overdosing on acetaminophen can result from taking a single large dose or repeatedly exceeding the recommended amount, leading to liver damage or hepatic failure 19 , Moreover, excessive consumption of the cough suppressant dextromethorphan can cause mental disorders, including hallucinations and delusions, which is another significant reason for its excessive use by some teenagers It is clear from the aforementioned observations that adolescents from diverse demographic backgrounds have varying concerns about drug attributes when self-medicating. Similarly, differences in concerns arise when adolescents choose different types of drugs. Disparities exist between the sale of OTC medications in the Chinese mainland and other countries. Comprehensive reports detailing adolescents' concerns regarding the efficacy and safety of self-medicated medicines in the Chinese mainland are lacking. This study aims to evaluate the prevalence of self-medication practices among Chinese adolescents and examine the factors they consider when purchasing and using OTC drugs. The language used in this text is clear, concise, and objective, with a formal register and precise word choice. The structure is logical, with causal connections between statements, and the text is free from grammatical errors, spelling mistakes, and punctuation errors. The content of the improved text is as close as possible to the source text, and no new aspects have been added. The anticipated outcomes aim to provide empirical evidence for the formulation of health policies and help to reduce the inappropriate use of OTC drugs among Chinese adolescents. For a detailed description of the method section see our previous study 24 , The investigation conducted multi-stage sampling in the Chinese mainland. All participants were informed and willingly signed a consent form prior to their involvement. In the cross-sectional investigation, the sample size for the bilateral test was determined using Formula 1. The proportion p of adolescents who reported self-medication behavior in Taiwan, China in was used, which was In this study, a total of questionnaires were collected, exceeding the minimum required sample size all participants came from the Chinese mainland. The inclusion criteria for participants in this study were as follows: 1 Age between 12 and 18 years old. Considering the possibility of respondents providing nominal ages age filled in being greater than their actual age , year-old participants were included in the study; 2 Self-reported purchase and use of over-the-counter drugs respondents answered 'yes' to the question regarding whether they had purchased and used over-the-counter drugs on their own ; 3 Voluntary participation in the study and completion of the informed consent form; 4 Participants could independently complete the online questionnaire or receive assistance from investigators if needed. In this study, a total of questionnaires were collected and subjected to logic checks. Ultimately, respondents were included, yielding an effective recovery rate of The questionnaire consists of three parts. The first part investigated the demographic and sociological characteristics of respondents, such as gender, age, ethnicity, location, place of residence urban and rural , education level, number of siblings, per capita monthly family income RMB to the USD exchange rate is the average rate for August etc. The second part investigated the status quo and essential considerations of adolescents' self-medication behavior, consisting of 3 questions 1 single-choice and 2 multiple-choice questions. The first single-choice question was 'Have you ever purchased and used OTC drugs by yourself? Those who answered 'no' were excluded from the study. The first multiple-choice question was, 'What kinds of OTC drugs have you purchased and used on your own? The second multiple-choice question was 'Which of the following factors do you think are the important factors for you to consider when you purchase OTC drugs by yourself? For each respondent, the order of the two multiple-choice questions was set as random to minimize bias in the study. The standardized HL index is calculated using the formula. The index range is 0—50, and its score positively correlates with the respondents' health literacy. The higher the index, the higher the health literacy level of the respondents. Concerning relevant literature, the health literacy of the respondents was divided into the high group more than 33 points and the low group 33 points or less. The grouping rules of each subscale were consistent with those of the full scale FHS-SF includes 10 items, 4 dimensions. Each item adopts the Likert 5-level scoring method, among which the sixth, ninth and tenth adopt reverse scoring; the higher the score is, the higher the family health level is Each dimension of the scale was included in this study for analysis. The respondents were divided into the high group greater than or equal to the median and low group less than the median according to the score of each dimension of FHS-SF. The Chinese versions of both scales have been validated, and the Chinese versions still measure depression and anxiety well PHQ-9 was developed by Spitzer et al. The Likert four-point scoring method was adopted to evaluate the following 9 aspects: decreased interest, low mood, sleep disturbance, fatigue, eating disorder, inferiority complex, difficulty concentrating, psychomotor delay, and suicidal symptoms. The main statistical index of this scale is the total score, and the total value of PHQ ranges from 0 to 27 points. The higher the score, the higher the degree of depression. In this study, according to the scoring rules, the respondents were divided into two groups: no depression 4 points or less and possible depression more than 4 points. GAD-7 was developed by Spitzer et al. It uses the number of days with related symptoms in the last two weeks as the evaluation standard. The degree of tension and anxiety, uncontrollable worry, excessive worry, inability to relax, inability to sit still, irritability, anger, and fear were respectively assessed. The main statistical index of this scale is the total score, which is scored by Likert four points. The total score ranges from 0 to 21, mainly used to assess the severity of anxiety symptoms; the higher the score, the higher the degree of anxiety. In this study, according to the scoring rules, the respondents were divided into two groups: no anxiety score 4 or less and possible anxiety score more than 4. Statistical analysis was performed using SPSS In this study, all scale scores were transformed into binary variables high and low groups by referring to relevant literature The classification variables were represented by frequency component ratio , and univariate binary logistic regression was used for univariate analysis. Multivariate binary stepwise logistic regression was used to analyze the factors related to the consideration of drug efficacy and safety among respondents. Finally, the respondents were divided into different subgroups based on gender and permanent residence, and multivariate binary stepwise logistic regression was conducted for each subgroup to perform a subgroup analysis. Two rounds of preliminary investigations were conducted before the formal investigation to refine the questionnaire based on the results. Trained investigators distributed questionnaires and assigned unique codes to each respondent to ensure anonymity. Every Sunday night, the research staff reviewed and provided feedback on the questionnaires collected by the investigators. After the questionnaire was collected, the logic check and data screening were carried out by two people back to back. If an outlier was identified during data analysis, the research team cross-checked the original questionnaire with the investigator before proceeding with further analysis. The study was conducted in accordance with the ethical standards set forth in the Helsinki Declaration All respondents in this study had a thorough understanding of the contents outlined in the informed consent form, and only those who voluntarily agreed to participate by signing the form were included. The results showed that the number of factors with a characteristic root greater than one was five. The variance contribution of the first principal factor was There were a few more female respondents than male respondents in this study; the largest number of respondents were from eastern China, and most of the respondents' usual place of residence was urban. The demographic and sociological characteristics are shown in Table 1. The findings showed that In this study, self-purchase and use of gynecological medication were included only for female respondents. Because only women tend to buy these drugs, the purchase of these drugs by men was not analyzed in this study. The percentage of respondents who had purchased and used gynecological drugs on their own was 4. Of the 22 people who chose 'other' and filled in the blanks, 12 filled in 'anti-cold medicine', 2 filled in 'ibuprofen', 2 filled in 'digestive medicine', 'anti-inflammatory', broad-spectrum antibiotic 'Amoxicillin', eye drops and Niuhuang antidote tablets were each filled by one person, as shown in Fig. The top two important considerations when purchasing OTC medicines were the safety of the medicine participants, Respondents in this study were categorized as being from eastern, central, and western China based on their location. According to the geographic heat map, respondents from western China had the highest prevalence of self-medication, more respondents from central China considered the efficacy of OTC drugs when self-medication, and more respondents from western China considered the safety of OTC drugs when self-medication. For details, in Figs. The consideration of drug effectiveness by individuals engaging in self-medication exhibited variation across diverse areas. The consideration of drug safety by individuals engaging in self-medication exhibited variation across diverse areas. As none of the scale scores met a normal distribution, the median, upper and lower quartiles were used to describe the concentration and dispersion degree trends of each scale score. The details of the scale scores for each scale are shown in Table 2. Univariate binary logistic regression analysis was used to conduct a univariate analysis of the types of OTC drugs the participants had purchased and used on their own. See Table 3 for details. Univariate binary logistic regression analysis of the variables related to the efficacy and safety of the drugs considered by the respondents when purchasing OTC drugs was conducted. See supplementary Materials, S2 Table for details. In this study, the dependent variable was whether respondents considered the drug efficacy as an important factor in self-medication. The regression model included location, place of residence, and gender as mandatory demographic characteristics. Additionally, monthly household income, ethnicity, education, being an only child, health literacy, family health status, and depression and anxiety were included in the regression model using stepwise regression. In particular, health literacy and family health were included in the model by calculating the total score and also by scoring the different dimensions of the scale measures. Logistic regression analysis indicated that health care literacy and family healthy lifestyle was associated with whether respondents considered drug efficacy as an essential consideration when purchasing OTC. See Table 4 for details. In this study, the dependent variable was whether respondents considered the drug safety as an important factor in self-medication. Logistic regression analysis indicated that place of residence, monthly per capita household income, whether only child, disease prevention literacy, and household health resources were associated with whether respondents considered drug safety as an essential consideration when purchasing OTC. Subgroup analysis was used with subgroup classification based on gender, location and place of residence to explore the variability of factors related to the dependent variable among different subgroups. The study results showed that the model built using data from each subgroup was generally consistent with the total model. Currently, nearly half of the people in the world do not have access to basic health services. Self-care has become a crucial way to promote primary health care and protect health for all. Thus, self-medication is widely used by people around the world as an important means of self-care. Studies have shown that self-medication is common among adolescents in countries including China, Australia, Malaysia, etc. This study reveals that the self-medication rate among Chinese adolescents aged 12—18 years is alarmingly high at This phenomenon may be related to the fact that they are in a critical period of growth. Previous studies 39 , 40 have shown that most adolescents face various kinds of vitamin and mineral deficiencies due to factors such as body growth, diet, exercise, and so on. The proportion of respondents who purchased antipyretic and analgesic drugs ranked second, indicating that most adolescents buy OTC drugs to alleviate fever or pain such as dysmenorrhea, headache, muscle pain, joint pain, etc. A Portuguese study also revealed that headache was the most common issue leading to self-medication among adolescents Of the 22 who answered 'others,' 12 responded with 'anti-cold medicine,' suggesting that some adolescents self-medicate to treat upper respiratory tract infections and the flu. Similar to this finding, the Portuguese study also revealed that the presence of symptoms of upper respiratory infections was a reason for adolescents to engage in self-medication The results showed that Chinese adolescents aged 12—18 years pay more attention to the safety, efficacy, and price of OTC drugs when making purchases. However, they give less consideration to characteristics such as drug taste and exquisite packaging. This finding aligns with the research results of Xu Jing et al. The results of univariate logistic regression analysis showed that the score of health care on the health literacy scale and the score on the family health scale were significantly related to the consideration of drug efficacy. Multivariate stepwise logistic regression analysis further found that better healthcare literacy would improve people's attention to the efficacy of drugs. Health literacy refers to an individual's ability to discover, understand, evaluate, and apply health-related information In the HLS-SF12 scale, the items in the healthcare dimension mainly involved disease treatment and drug-related information Therefore, people with higher scores in the healthcare dimension tend to be more aware of drug information and better judge the advantages and disadvantages of treatment options, paying more attention to the therapeutic effect of drugs. In addition, those with high family healthy lifestyle scores were more likely to consider drug efficacy an essential factor. Family is the most basic unit of social life, and a healthy lifestyle manifests good family function. It helps family members to actively understand the knowledge and skills related to drug treatment and change their cognition and behavior to maintain a healthy state 44 , Therefore, people with high family healthy lifestyle scores usually have a strong health awareness and pay more attention to the efficacy of drugs. The results of univariate logistic regression analysis showed that the family income per capita, the score of the disease prevention dimension in the health literacy scale and the score of the family health scale were significantly related to the emphasis on drug safety. Multivariate stepwise logistic regression analysis further found that compared with those with higher per capita monthly household income, those with lower per capita monthly household income were more likely to regard drug safety as an essential factor. Sun Shan once pointed out that groups with different economic conditions have apparent differences in OTC drug consumption and expenditure patterns The lower income group is obliged to receive the drug treatment generally after the disease when pain has affected the everyday work and life of the case Therefore, they usually pay more attention to the safety of drugs and hope to avoid secondary drug treatment expenses and secondary physical injuries caused by adverse drug reactions or side effects. The results of this study indicated that urban adolescents were more concerned about the safety of medications than rural adolescents. This difference is likely to be influenced by the disparity in education between urban and rural areas. Existing studies suggest that rural adolescents do not improve their health literacy as much as urban adolescents do, even with the same level of health education Therefore, this group does not possess the necessary knowledge to prioritize medication safety when self-medication. The findings of this study also suggest that non-only children are more likely to be concerned about the safety of medicines when self-medication. This is likely related to the fact that non-only children often need to share the family stockpile of medicines with their siblings. In such cases, non-only children will be exposed to a wider variety of medicines, and therefore, they need to be more concerned about the safety of medicines when self-medication. At the same time, the higher the score for disease prevention, the more inclined people will be to consider drug safety as an essential factor. In the HLS-SF12 scale, the items of the disease prevention dimension mainly involve emotion management, physical examination cognition and vaccine demand. Therefore, people with higher scores in the disease prevention dimension are more effective in protecting themselves from disease. As a result, they will naturally pay more attention to the drug's safety and carefully judge whether the drug will cause other diseases or adverse reactions. Regarding family health status, those with better family health resources were more willing to consider drug safety as an essential factor. Household health resources refer to the material and non-material assets a household can carry out daily activities and perform its functions, including money, housing, and health care 48 , Therefore, those with better family health resources have better access to healthcare resources and are more likely to obtain medical care and scientific medication knowledge, so they pay more attention to drug safety. Self-medication plays an integral role in complementing health care and treating diseases. Especially under the influence of the COVID pandemic, many Chinese adolescents who have just entered university need to comply with the epidemic prevention and control regulations of their schools, which may inconvenience their medical treatment. Scientific and rational self-medication can make adolescents get treatment at a lower cost and a higher convenience. However, adolescents' inappropriate self-medication behavior may negatively affect their health. Adolescents' judgment and self-care abilities are typically far worse than adults. It is necessary to strengthen the management of OTC drugs sold to adolescents and health education on self-medication for adolescents. The respondents included in this study were aged between 12 and 18 years, and this range included those in tertiary education and those who were not. Since both have changed dramatically in knowledge and lifestyle, the suggestions will be made towards health departments, drug manufacturers and distributors, media, schools and families for respondents with different education levels. First, health authorities should establish a regulatory system, especially for adolescents who buy OTC drugs, pay attention to their self-medication needs, and make adolescents able to purchase the drugs they need with the help of pharmacists or other professional medical staff. Secondly, drug manufacturers should make the labels of OTC drugs more easily identifiable on the drug packaging and make it easier to explain how to use drugs scientifically and correctly in the outer packaging and instructions. Adolescents who do not receive higher education spend most of their time in the family and school environment. Therefore, for these adolescents, the role of schools and families in the scientific use of OTC drugs should be valued. Schools should pass more scientific knowledge of medication in class, and families should pass correct and scientific medication concepts. For those receiving higher education, health education on the scientific use of non-prescription drugs should be promoted in classrooms, associations, publicity posters and other forms on university campuses. In addition, these university students are exposed to many online media, so the media should pay attention to the accuracy of information when transmitting medication information. Health authorities should pay attention to and regulate online OTC drug purchase channels and strengthen the monitoring of online OTC drug sales. Finally, adolescents and their families should take the initiative to learn how to scientifically identify and use OTC drugs. In a randomized controlled trial in Japan, proactive use of self-medication knowledge provided by pharmacists was shown to be effective in promoting safe self-medication behavior among the public 50 ; Other studies have shown that the drug use behavior of adolescents can be improved to a certain extent with the intervention of media This study has several strengths. Firstly, we utilized data from a cross-sectional survey conducted in the Chinese Mainland in Moreover, the survey employed a multi-stage sampling method to obtain a representative sample. Additionally, we combined family health, health literacy, and mental health status to analyze adolescents' non-prescription drug purchase behavior, which enriched the theoretical application value of health literacy in the field of adolescent self-medication. Targeted suggestions were provided for the future health promotion and health education practices of scientific medication in adolescents. Practical contributions were also made. This study has several limitations. Firstly, the data is based solely on self-report questionnaires, which can be influenced by social expectations, self-report errors, and poor memory. Secondly, a cross-sectional design was used in this study. The results were only used to explore the factors associated with the dependent variable, which did not allow for causal inferences to be made based on the findings. Thirdly, the study participants were Chinese adolescents. As adolescence is a unique stage in life, the results of this study may not be generalizable to other countries. To address this limitation, future studies should aim to include participants from more diverse countries or regions. The behavior characteristics of adolescents and other critical factors they consider when purchasing OTC medications may change in subsequent years. Chinese adolescents aged 12—18 frequently use OTC drugs for self-medication. The likelihood of considering drug safety as essential was negatively correlated with monthly family income, while health literacy and family health status were positively correlated with considering drug efficacy and safety as essential. This study examines the variables related to the importance of considering the efficacy and safety of drugs during adolescent self-medication. The findings provide research ideas for future exploration of factors to be considered when standardizing follow-up studies of adolescent self-medication behavior. Additionally, the results can serve as a basis for relevant departments to formulate policies to regulate adolescent self-medication behavior. Further studies can investigate the variables associated with the significance of additional factors in adolescents' self-medication, as well as intervention models and methods to encourage rational self-medication in adolescents. World Health Organization. Gualano, M. Use of self-medication among adolescents: A systematic review and meta-analysis. Public Health 25 , — Article PubMed Google Scholar. Elong Ekambi, G. Knowledge, practices and attitudes on antibiotics use in Cameroon: Self-medication and prescription survey among children, adolescents and adults in private pharmacies. PLoS One 14 , e Mathias, E. Self-medication practices among the adolescent population of South Karnataka, India. Public Health , Skarstein, S. Pain and development of identity in adolescents who frequently use over-the-counter analgesics: A qualitative study. Shehnaz, S. A systematic review of self-medication practices among adolescents. Health 55 , — Rutter, P. Abel, C. Nonprescription medication use and literacy among New Hampshire eighth graders. Article Google Scholar. James, H. Evaluation of the knowledge, attitude and practice of self-medication among first-year medical students. Jonassen, R. Over-the-counter analgesics use is associated with pain and psychological distress among adolescents: A mixed effects approach in cross-sectional survey data from Norway. BMC Public Health 21 , Bertoldi, A. Tracking of medicine use and self-medication from infancy to adolescence: Pelotas Brazil birth cohort study. Health 51 , S Kiza, A. Over-the-counter analgesics: A meta-synthesis of pain self-management in adolescents. Pain Manag. Sloand, E. Self-medication with common household medicines by young adolescents. Issues Compr. Lee, C. Inappropriate self-medication among adolescents and its association with lower medication literacy and substance use. PLoS One 12 , e Italia, S. Utilization of self-medication and prescription drugs among year-old children from the German GINIplus birth cohort. Drug Saf. Finkelstein, Y. Drug misuse in adolescents presenting to the emergency department. Care 33 , — Vidourek, R. Hispanic youth involvement in over-the-counter drug use: Parent, peer, and school factors. Benotsch, E. Intentional misuse of over-the-counter medications, mental health, and polysubstance use in young adults. Community Health 39 , — Wilson, K. Knowledge gaps and misconceptions about over-the-counter analgesics among adolescents attending a hospital-based clinic. Swedish teenagers and over-the-counter analgesics—Responsible, casual or careless use. Schillie, S. Medication overdoses leading to emergency department visits among children. Jensen, J. Association of maternal self-medication and over-the-counter analgesics for children. Pediatrics , e—e Romanelli, F. Dextromethorphan abuse: Clinical effects and management. Ge, P. Self-medication in Chinese residents and the related factors of whether or not they would take suggestions from medical staff as an important consideration during self-medication. Public Health 10 , Zhang, Z. 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China Market. Google Scholar. Health literacy and public health: A systematic review and integration of definitions and models. BMC Public Health 12 , 80 Yan, W. A study on the correlation between perinatal health literacy and family functioning of mothers of preterm infants in NICU. China Health Educ. Wei, Z. Shan, S. A study on the purchase channel choice and influencing factors of urban and rural OTC consumers in Fuzhou City Master. Fujian Agriculture and Forestry University, Tragler, A. Health education in school children. Indian Pediatr. Daines, C. Effects of positive and negative childhood experiences on adult family health. Crandall, A. The family health scale: Reliability and validity of a short- and long-form. Public Health 8 , Tachi, T. Scalzi, L. Improvement of medication adherence in adolescents and young adults with SLE using web-based education with and without a social media intervention, a pilot study. Online J. Download references. The authors hereby declare that this study acknowledges the financial support provided by the 'Hainan Province Specialized Key Discipline—Public Health and Preventive Medicine' Construction Project for this study. You can also search for this author in PubMed Google Scholar. Conceptualization: P. Data Curation: K. Formal Analysis: P. Methodology: D. Writing—Original Draft Preparation: D. Writing—Review and Editing: W. Supervision: X. Correspondence to Yibo Wu or Qiqin Feng. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. The original online version of this Article was revised: In the original version of this Article, Yibo Wu was omitted as a corresponding author. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Reprints and permissions. Liu, D. Status of self-medication and the relevant factors regarding drug efficacy and safety as important considerations among adolescents aged 12—18 in China: a cross-sectional study. Sci Rep 14 , Download citation. Received : 11 June Accepted : 08 April Published : 01 May Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily. Skip to main content Thank you for visiting nature. Download PDF. Subjects Health care Public health. This article has been updated. Abstract The objective of this study was to investigate self-medication behavior among Chinese adolescents aged 12—18 years and explore the factors associated with whether adolescents prioritize drug efficacy or safety when engaging in self-medication behavior. Knowledge attitude and convenience on self-medication practices among university students in Bangladesh exploration using structural equation modeling approach Article Open access 12 May A report of Kabul internet users on self-medication with over-the-counter medicines Article Open access 25 May Examining factors that influence medication adherence with children seen at outpatient department in Western China: a cross-sectional survey Article Open access 05 October Introduction Self-medication is a widespread practice where individuals choose and use drugs to treat self-diagnosed illnesses or symptoms, or the intermittent or continued use of prescribed drugs for chronic or recurrent diseases or symptoms 1. Methods For a detailed description of the method section see our previous study 24 , Participants Sample size In the cross-sectional investigation, the sample size for the bilateral test was determined using Formula 1. Demographic and sociological characteristics of respondents and important considerations in their self-medication behaviors There were a few more female respondents than male respondents in this study; the largest number of respondents were from eastern China, and most of the respondents' usual place of residence was urban. Full size table. Figure 1. Types of OTC medicines that respondents bought and used on their own. Full size image. Figure 2. Factors of the drug itself that respondents focus on when self-medicating. Figure 3. Distribution of self-medication behaviors by region. Figure 4. Figure 5. Table 2 Scores on each scale. Table 3 Univariate binary logistic regression of the types of OTC respondents had purchased. Table 4 Multivariate binary stepwise logistic regression results: whether respondents consider drug efficacy as an important consideration in purchasing OTC. Table 5 Multivariate binary stepwise logistic regression results: whether respondents consider drug safety as an important consideration in purchasing OTC. Factors related to drug efficacy or safety as an important consideration in Chinese adolescents Proportion of important considerations when self-medication The results showed that Chinese adolescents aged 12—18 years pay more attention to the safety, efficacy, and price of OTC drugs when making purchases. Drug efficacy The results of univariate logistic regression analysis showed that the score of health care on the health literacy scale and the score on the family health scale were significantly related to the consideration of drug efficacy. Drug safety The results of univariate logistic regression analysis showed that the family income per capita, the score of the disease prevention dimension in the health literacy scale and the score of the family health scale were significantly related to the emphasis on drug safety. Suggestion Self-medication plays an integral role in complementing health care and treating diseases. Strengths and limitations of the study Strengths This study has several strengths. Limitations This study has several limitations. Conclusion Chinese adolescents aged 12—18 frequently use OTC drugs for self-medication. Data availability All data, models, and code generated or used during the study appear in the submitted article. References World Health Organization. Article Google Scholar James, H. Article Google Scholar Schillie, S. Article Google Scholar Ge, P. Google Scholar Wei, Z. Google Scholar Shan, S. Acknowledgements The authors hereby declare that this study acknowledges the financial support provided by the 'Hainan Province Specialized Key Discipline—Public Health and Preventive Medicine' Construction Project for this study. View author publications. Ethics declarations Competing interests The authors declare no competing interests. Additional information Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Supplementary Information. Supplementary Tables. About this article. Cite this article Liu, D. Copy to clipboard. Publish with us For authors Language editing services Submit manuscript. Search Search articles by subject, keyword or author. Show results from All journals This journal. Advanced search. Close banner Close. Email address Sign up. Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing.

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A woman uses self-service machine to buy drugs at a 'future drugstore' in Zhengzhou, capital of central China's Henan Province, May 24, A 'future drugstore' of Alipay opened here on Thursday, which permits face-scanning paying, remote healthy consulting, enquiry reservation, hour self-service drug selling and other services. China launches relay satellite to explore Moon's far side. Aerial view of Laoshan mountain scenic zone in Qingdao. When birds foraging. Farmers plough in fields with cattle in SW China's Guizhou. Video Player Close.

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