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Закладки кокса Ларнака
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In Vitro Antiproliferative Potential and Antioxidant Capacity of New Coordination Compounds
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In Vitro Antiproliferative Potential and Antioxidant Capacity of New Coordination Compounds
By using our site, you agree to our collection of information through the use of cookies. To learn more, view our Privacy Policy. To browse Academia. Также была исследована их цитотоксичность в отношении нормальных эпителиальных клеток почки собаки Madin Darby линии MDCK. Жизнеспособность раковых клеток определяли по тесту Alamar Blue с использованием окислительно-восстановительного индикатора ресазурина. Полученные результаты показали, что вещества TIA и TIA обладают высоким антипролиферативным и антиоксидантным потенциалами. Цитотоксическая активность этих соединений в отношении нормальных клеток линии MDCK ниже, чем в опухолевых клетках, что указывает на перспективность их использования в качестве противоопухолевых средств. Однако, необходимы дополнительные исследования для о Lesya Kobylinska. Olexandr Smolsky. Synthesis and study of antioxidant properties of \\\\\\\\\[1,2,4\\\\\\\\\]triazolo\\\\\\\\\[1,5-a\\\\\\\\\]pyridine derivatives and their potential toxicity using preclinical diagnostic methods. Derivatives of \\\\\\\\\[1,2,4\\\\\\\\\]triazolo\\\\\\\\\[1,5-a\\\\\\\\\]pyridine were synthesized on the basis of 2-aminopyridines and ethyl isothiacyanatocarbonate, with subsequent cyclization of intermediate adducts. The resulting 2-amino\\\\\\\\\[1,2,4\\\\\\\\\]triazolo\\\\\\\\\[1,5-a\\\\\\\\\]pyridines were reacted with isoamyl nitrite in the presence of CuHal2, which led to the synthesis of volatile 2-halogeno\\\\\\\\\[1,2,4\\\\\\\\\]triazolo\\\\\\\\\[1,5- a\\\\\\\\\]pyridine. The toxicity of the obtained compounds was studied by the degree of hemolysis of erythrocytes in a hypotonic NaCl solution. The intensity of free-radical oxidation of lipids was assessed spectrophotometrically by the formation of TBА-active products. The antioxidant activity of the substances was determined by inhibiting the oxidation of adrenaline under conditions of artificial oxidative stress. Scientific novelty. For the first ti Konstantin Puzakov. This review analyzes the literature on the effects of certain drugs with antioxidant properties on the risk of developing malignant neoplasias, as well as on their growth and metastasis. Antioxidants are able to protect not only normal cells from the alterative effect of free radicals, but also tumor cells, thereby stimulating their survival and growth. There are data showing that in cells of certain malignant tumors, concentrations of endogenous antioxidant proteins are increasing. The p53 protein, which activates apoptosis in diseased cells, can be inactivated by antioxidants, which in turn can stimulate the survival and growth of malignant tumor cells. Currently, there is a sufficient amount of information about the effect on tumor growth of certain drugs of various pharmacological groups with anti Eva Berezhnaya. Pavel Maslennikov. This monograph presents modern concepts of free- free radicals, free radical oxidation of cellular components of antioxidants. Examined in detail the effect of environmental factors on antioxidant enzymes: superoxide dismutase, glutathione peroxidase, catalase, dehydro ascorbate reductase, ascorbate and antioxidant pigments - anthocyanins. Любомир Побережний. The use of inhibitors remains one of the most effective and economically sound methods of corrosion protection. Since universal inhibitors do not exist, effective inhibitors or compositions should be developed for each individual case. The inhibitory properties of N-phenyl-decahydroacridindiones-1,8 in groundwater were investigated in thisresearch the by electrochemical and gravimetric methods. The subject of the investigation. Methods of investigation. Antioxidant activity was evaluated by inhibiting lipid peroxidation reaction and adrenalin autoxidation. Main results. It was determined that herb extracts, gathered during budding and blooming stages, had higher antioxidant and antiradical activity which is explained by high content of polyphenolic compounds, in particular flavo It was determined that herb extracts, gathered during budding and blooming stages, had higher antioxidant and antiradical activity which is explained by high content of polyphenolic compounds, in particular flavonoid Sergey Andreev. The epidemic associated with the new Sars-CoV-2 coronavirus has affected almost all countries of the world and no reliable treatment for this infection exists yet. One of the currently widely accepted approaches for finding active compounds is based on the possibility of using existing drugs approved by government medical organizations as the FDA. Their choice is based on screening, based on the use of computer models that evaluate the specific binding energy minimization of such drugs to target molecules that are important for the life cycle. Thus, a few well-known antiviral drugs against HIV, hepatitis C and others selected on this basis exerted an antiviral effect in vitro, but their real effectiveness was far fr Kamil Kuca. This is because innovative multi-target-directed ligands MTDLs could more adequately address the complexity of this pathological condition. In a continuation of our efforts aimed at a new series of anti-AD MTDLs, we combined the structural features of the cholinesterase inhibitor drug tacrine with that of resveratrol, which is known for its purported antioxidant and anti-neuroinflammatory activities. In addition, 12 showed intriguing anti-inflammatory and immuno-modulatory properties in neuronal and glial AD cell models. Importantly, the MTDL profile is accompanied by high-predicted blood-brain barrier per Log in with Facebook Log in with Google. Remember me on this computer. Need an account? Click here to sign up. Download Free PDF. Olga Tagadiuc. Related Papers. Modern ideas about the effect of exogenous antioxidants on the growth of malignant tumors. Антиоксидантная и антирадикальная активность in vitro экстрактов травы sanguisorbaofficinalisl.
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In Vitro Antiproliferative Potential and Antioxidant Capacity of New Coordination Compounds
Закладки кокса Ларнака