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At the time, we wrote something about the rectal use of MDMA E-by-bum because it sounded a bit funny. A few years ago, GDS followed that up with a more serious piece about the phenomena of people using drugs rectally, the science behind it pardon the pun and how rectal use of drugs may convey certain benefits, though it requires a bit of planning, patience, practice and equipment. GDS took a more in depth look at the different way people use MDMA pills and powders around the world and that what I want to talk about here. Route of use is very important when thinking about drug effects both pleasure and risk and is probably overlooked compared to dose and drug purity. Snorting drugs can be an effective route of administration for some drugs more than others. The substance needs to able to be ground to a fine enough powder and be water soluble to be absorbed into the mucus lining the nose and then into nasal blood vessels. The mucus tends to trap a lot of the powder stopping immediate absorption, effectively slowly down the absorption into the nose. Of course, you also end up swallowing quite a bit of it as well, often noticed as the foul taste in your mouth when you sniff and swallow. Snorting usually results in a more rapid onset of action than oral use because the nasal membrane is very porous and some of the drug gets directly into the blood stream by being absorbed directly into the blood vessels lining the nose. Snorting also generally results in more drug being absorbed when you swallow. Although snorting drugs allows some of drug to avoid being broken down by the liver on its first pass through the body, the lining of the nose does in fact contain enzymes so not all the snorted MDMA escapes untouched. All of this makes snorting MDMA attractive in terms of getting a quicker buzz than taking it orally and in some cases, might give you more bang for buck. On the other hand, the duration of drug effect when snorting tends to be shorter lived than when taking it orally meaning people need to re-dose more frequently. What makes the Danes and Kiwis the leaders in snorting MDMA around the world is unclear let us know if you have ideas. Surely that is all the same? The physical form of the MDMA you swallow can dramatically affect the bioavailability the rate that the drug is absorbed of the drug. For example, a very hard tablet is likely to release the drug much more slowly than a very soft crumbly one or a powder or crystal. Dissolve that powder in a drink and you may increase the speed of absorption even more. This becomes important when thinking about re-dosing over the course of a session. While re-dosing may be driven because a user feels the effects are wearing off, early re-dosing may also occur because users become impatient waiting for a drug effect and this can lead to accidental consumption of an excessive dose. Just how the different preferences for routes of use have evolved in different countries has evolved is not obvious — if you have any idea please share them with us. While it might have something to do with the most common form of the drug available in different countries as the table below shows most countries have both. Where powder was the dominant form available there were marked differences between whether countries adopted routes better suited to dabbing, bombing, drinking or snorting. The Canadians with highest rates of powder use alone hardly ever used these routes, whilst the Italians and Greeks showed a preference for drinking their MDMA dissolved in a drink. Conversely the Danes and Kiwis chose snorting, whilst the Spanish and Belgians opted for the dab, when they were not swallowing a pill or capsule. Route and purity aside the other major factor impacting on the effects people get from powders is how much they use — dose pretty much can trump any effect of route of use if you take enough. There was a huge variation among users from every country in how they usually measured their dose when using powder see Figure 2 below. The most common approach was to crush MDMA crystal and make a guess. After spending 9 hours in a lab crushing various pills and powders and weighing them for the pictures we used in the drugs meter minutes I can vouch that with practice this method may be more accurate that at first it might seem. But I had the benefit of mg scales and measured every dose so I has a good idea of how good my guesses were over the course of the day. I think without some baseline reference point — this approach could be quite risky. Full marks must go the nearly 1 in 4 who weighed their powders out — that is the gold standard if you are using good scales. How you use your MDMA matters. Dose if probably the biggest variable and knowing as much about your drug in terms of composition or purity before you take it is a useful thing. And the average time between doses was 75 minutes. So, it seems to GDS that these helpful approaches could be more widely adopted. If you value our research, we would greatly appreciate your contribution Please help us continue in our work. December November May June
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