What Is Pragmatic Free Trial And Why Is Everyone Dissing It?
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Pragmatic trials are studies designed to inform the real-world practice of clinical. They are often characterized as focusing on practical aspects of study design which include the recruitment and consent process, as well as adherence and the use of standard equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from different geographic areas. This type of heterogeneity is required for pragmatic trials to be able to prove their validity, and it also helps to reduce bias in the results. A high degree of heterogeneity, however, can cause problems with the trial design.
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Legality
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The goal of pragmatic trials is to simulate real-life scenarios and to achieve the highest level of validity externally. They are typically ordered by policymakers and practitioners to help inform their decisions. They can be used to determine the causality of an intervention and its results. However, they shouldn't be used as a substitute for explanatory trials.
The pragmatism concept is controversial and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the clinical or physiological hypothesis as well as pragmatic trials that inform policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the traits of a pragmatic research study that includes recruitment, design, implementation of the intervention, and follow-up.
There is an encouraging trend in the number of pragmatic trials that are published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more acquaint to the subject of pragmatics. It is important to note that the majority of these studies were conducted in primary care settings.