WHY REDUCE PROLACTIN AND HOW TO DO IT

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Among anabolic steroids, there are drugs that, in addition to raising estradiol due to aromatization (converting testosterone to estradiol), can increase prolactin. These drugs are called gestagens (progestins). The most popular of them are: nandrolones, trenbolone and trestolone. Among all, the leader of prolactin increase is nandrolone.

Some peptides, such as GHRP-2 and GHRP-6, as well as antidepressants, and diseases such as pituitary adenoma can also increase prolactin.

🔍 Other possible causes

The excess of the normal hormone prolactin in the male body (hyperprolactinemia) most often occurs under the influence of such factors:

Autoimmune pathologies
Benign and malignant neoplasms of the central nervous system (prolactinoma)
The consequences of chronic renal failure
Neuroinfections (inflammation of the arachnoid membrane of the brain, neurosyphilis)
Progressive liver failure
The presence of a hematoma near the pituitary gland
Previously suffered a traumatic brain injury
Taking medications from the group of neuroleptics, prokinetics and antidepressants
Thyroid dysfunction

Excessive production of prolactin in the male body can be triggered by additional factors such as overeating, chronic lack of sleep, smoking, alcohol abuse, stress, moral and physical fatigue.

🚨 Negative effects of high prolactin levels

An increase in prolactin above the reference values causes the significant negative consequences: fluid retention, decreased libido and worsening of erection, infertility, a decrease in secondary sexual characteristics, an increase in the female type of mammary glands (gynecomastia) and possible discharge from them. High prolactin worsens your cholesterol levels, impairs lipid metabolism and increases the tendency of obesity. Also, there is evidence of an increased risk of type 2 diabetes. In the long term, it leads to a decrease in bone mineral density. Your bones become more fragile.

Many athletes complain of mood: apathy, nervousness and anxiety, irritability, emotional instability, and even the development of psychosis during elevated prolactin levels periods. Cases of depression, high fatigue, memory impairment, poor concentration, and pain in the heart are common. Vegetative disturbances are also possible.

Prolactin performs its functions in the body and its level must be appropriate. The action of prolactin in the male body has not yet been fully studied, but it is already clear that too low prolactin negatively affects the immune system.

👑 Nandrolone is the king of prolactin enhancement

The main side effects of 19-nortestosterone class steroids are associated with an increase in prolactin levels. Nandrolone increases prolactin more than the rest. Prolactin has the most negative effect on men when it rises in the brain. By binding to the progestin receptors of the pituitary gland, nandrolones increase the production of prolactin and suppress the secretion of gonadotropic hormones. Suppressed libido, depressive mood, low self-esteem, and increased hysteric emotionality are just a few of the prolactin’s negative effects.

How high your prolactin will rise when using nandrolone depends directly on the dosage that you use as well as on the characteristics of your body. Some athletes do not have problems with prolactin using even such high dosages as 800 mg per week, but someone with high prolactin and a complete lack of erection will already be at 200 mg per week.

✔️ How to decrease prolactin

Elevated prolactin should be reduced with medication. here are several drugs to reduce it: they are all essentially dopamine receptor stimulants. Typically, drugs such as bromcreptine and cabergoline are used for these purposes.

Bromocriptine is the first generation of such drugs with a rougher effect and a large number of significant side effects, while cabergoline is a more modern drug, with a longer effect, better tolerance and same effectiveness.

In order to lower the level of prolactin, a drug such as Caberos (Cabergoline) is excellent. Almost always used if you are going to use nandrolone or trenbolone, trestolone and if your prolactine is high. Cabergoline completely removes all the negative effects of high prolactin levels. Bromocriptine should be taken 1-2 times a day, while cabergoline - 1 time in 7 days.

Another possible solution to reduce prolactin levels is high dosages of Coenzymated Vitamin B6 (Pyridoxal-5-Phosphate). Dosages should be selected individually, starting from 100-200 mg and ending with 300 mg per day. Despite the fact that the substance is a vitamin, it also has a number of side effects, it is important to consider taking it.

💊 Cabergoline

Cabergoline is a selective dopamine receptor agonist. This drug is highly specific in its actions, with a strong affinity for the dopamine D2 receptor, and a low affinity for dopamine Dl, A 1-adrenergic, A2-adrenergic, 5-HT1- serotonin, and 5-HT2-serotonin receptors. Its main clinical use is for the treatment of hyperprolactinemia, or the hypersecretion of prolactin from lactotropes in the anterior pituitary (pituitary tumor is a common cause of this disorder). It is also applied in the management of Parkinson's disease.

Cabergoline effectively inhibits prolactin secretion, which it does by mimicking the actions of dopamine on the D2 receptor (dopamine normally serves as negative feedback for prolactin release). As a targeted agonist of the dopamine D2 receptor, cabergoline should not affect other pituitary hormones like growth hormone (GH), luteinizing hormone (LH), corticotrophin (ACTH), or thyroid-stimulating hormone (TSH).

In addition, interaction with other receptors was established: D3, D4, 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, α2B

The elimination half-life of cabergoline estimated from urinary data of 12 healthy subjects ranged between 63 to 69 hours. The prolonged prolactin-lowering effect of cabergoline may be related to its slow elimination and long half-life.

After oral dosing of radioactive cabergoline to five healthy volunteers, approximately 22% and 60% of the dose was excreted within 20 days in the urine and feces, respectively. Less than 4% of the dose was excreted unchanged in the urine.

There is a myth on the Internet that says that cabergoline is extremely dangerous for your heart, but to debunk this myth, we want to give arguments in the form of initiated studies where cabergoline was used for a very long time and did not cause increased risks [1], [2], [3]

🤔 How to use it

The dosage of cabergoline will depend on your prolactin levels, and most often it depends on how high dosages of nandrolone or trenbolone you are using. Most often, the minimum recommended dosage is 0.125-0.250 mg (250 mcg) per week, but is in any case, to understand the optimal dosage, you will need to take a prolactin blood test before taking it. Based on the obtained values, you will be able to more accurately select the dosage required specifically in your case.

Most often, the initial dose to check how much prolactin will drop is the minimum is 0.125-0.250 per week, after which a blood test is taken and the result is compared. Usually, several weeks of admission is enough to bring prolactin back to normal reference values, but each time you need to check the blood tests.

The optimal dose and frequency of administration is selected under the control of blood tests of the prolactin, since the effect of the drug is different and depends on the individual characteristics of the body. In clinical medicine, this drug may be taken for 6 months or longer.

When used by athletes/bodybuilders to inhibit prolactin secretion (as with lactating gynecomastia), doses on the lower end of the therapeutic range are most commonly used. although athletes/bodybuilders usually find a 4-6 week course of therapy (combined with an intelligent rearrangement of the offending drugs) most appropriate.

When used medically to inhibit prolactin secretion (for example, due to prolactinoma), cabergoline is given in an initial dosage of 500mcg per week. This may be taken in one single dose or divided into 2 or more doses on separate days.

Important note: when taking prolactin blood tests, you must refrain from sexual intercourse or masturbation for 24 hours. It is known that after orgasm, the level of prolactin in the male body jumps strongly and remains high for some time.

❓ When to start reducing prolactin

Many amateurs do not know that high prolactin have a lot of negative effects and never reduce prolactin without understanding why their libido is low even with high testosterone and their cycle results lower than they could be

It is necessary to decrease prolactin to normal values. Sometimes prolactin even slightly above the reference values can already cause the above problems, but sometimes the athlete does not notice its negative effects even if prolactin is overestimated twice as much as the allowable values. This does not mean that it can be left elevated.

Always keep an eye on your blood counts and have a drug such as cabergoline on hand if you are going to use progestogens. You also need to keep in mind that prolactin can increase directly, even if there are no drugs in your course that directly increase its values, and even if you are not on the course.

⚠️ Negative effects of Low Prolactin

Using cabergoline or any other means to reduce prolactin, you should do a blood test and always know the value of your prolactin. Too low a level of this hormone is fraught with a decrease in immunity and infertility. The results of one study show that men with very low prolactin levels are characterized by impaired sexual function and poor well-being [4].

💊 Using cabergoline for sexual enchantment

Cabergoline also has interesting property – namely, to increase sexual desire. Recently, the use of this drug in this way has become very popular. The fact is that cabergoline stimulates dopamine receptors., and dopamine is known is known to be an active neurotransmitter that plays important role in the formation of libido. Cabergoline has a positive effect on the pleasure of sexual life, pleasure in the process of sex, the power of orgasm, reduces the refractory period

Cabergoline is most commonly used to treat disorders caused by elevated levels of the hormone prolactin, which is produced by the pituitary gland. Excess prolactin can trigger a range of issues, such as infertility, sexual dysfunction, loss of bone mass, as well as breast pain and tenderness. In men, excessive prolactin can lead to various sexual disorders, including:

Erectile dysfunction
Decreased libido
Reduced fertility

Some studies suggest that cabergoline can be an effective treatment for erectile dysfunction in certain men. Erectile dysfunction is a condition where achieving or maintaining an erection is difficult, and its causes can be both physiological and psychological. Results from a 2007 study involving 50 men, along with a clinical case in 2015, indicate significant improvement in orgasmic function in men with psychological or psychogenic erectile dysfunction when using cabergoline [5].

Online, there are references to a clinical study using cabergoline and tadalafil, which showed their positive impact on men with psychogenic erectile dysfunction (ED, caused by factors like low self-esteem and performance anxiety).

Cabergoline has also shown effectiveness in treating delayed orgasm – a condition sometimes referred to as orgasmic disorder, anorgasmia, or delayed ejaculation. A 2016 analysis of the condition of 131 men who were taking cabergoline showed significant improvement in their ability to achieve orgasm [6].

[1] pubmed.ncbi.nlm.nih.gov/18594989
[2] pubmed.ncbi.nlm.nih.gov/23824978
[3] pubmed.ncbi.nlm.nih.gov/28217516
[4] pubmed.ncbi.nlm.nih.gov/35636912
[5] pubmed.ncbi.nlm.nih.gov/16728967
[6] pubmed.ncbi.nlm.nih.gov/26944776