W K MCALISTER JR
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James Knox Polk (; November 2, 1795 – June 15, 1849) was the 11th president of the United States, serving from 1845 to 1849. A protégé of Andrew Jackson and a member of the Democratic Party, he was an advocate of Jacksonian democracy and extending the territory of the United States. Polk led the U.S. into the Mexican–American War, and after winning the war he annexed the Republic of Texas, the Oregon Territory, and the Mexican Cession. After building a successful law practice in Tennessee, Polk was elected to its state legislature in 1823 and then to the United States House of Representatives in 1825, becoming a strong supporter of Jackson. After serving as chairman of the Ways and Means Committee, he became Speaker of the House in 1835, the only person to serve both as Speaker and U.S. president. Polk left Congress to run for governor of Tennessee, winning in 1839 but losing in 1841 and 1843. He was a dark-horse candidate in the 1844 presidential election as the Democratic Party nominee; he entered his party's convention as a potential nominee for vice president but emerged as a compromise to head the ticket when no presidential candidate could gain the necessary two-thirds majority. In the general election, Polk narrowly defeated Henry Clay of the Whig Party and pledged to serve only one term. After a negotiation fraught with the risk of war, Polk reached a settlement with Great Britain over the disputed Oregon Country, with the territory for the most part divided along the 49th parallel. He oversaw victory in the Mexican–American War, resulting in Mexico's cession of the entire American Southwest. He secured a substantial reduction of tariff rates with the Walker tariff of 1846. The same year, he achieved his other major goal, reestablishment of the Independent Treasury system. True to his campaign pledge to serve one term (one of the few U.S. presidents to make and keep such a pledge), Polk left office in 1849 and returned to Tennessee, where he died of cholera soon afterward. Though he has become relatively obscure, scholars have ranked Polk in the upper tier of U.S. presidents, mostly for his ability to promote and achieve the major items on his presidential agenda. At the same time, he has been criticized for leading the country into a war with Mexico that exacerbated sectional divides. A property owner who used slave labor, he kept a plantation in Mississippi and increased his slave ownership during his presidency. Polk's policy of territorial expansion saw the nation reach the Pacific coast and almost all its contiguous borders. He helped make the U.S. a nation poised to become a world power, but with divisions between free and slave states gravely exacerbated, setting the stage for the Civil War.
In connection with: James K. Polk
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Vitamin K is a family of structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation ("K" from Danish koagulation, for "coagulation") and for controlling binding of calcium in bones and other tissues. The complete synthesis involves final modification of these so-called "Gla proteins" by the enzyme gamma-glutamyl carboxylase that uses vitamin K as a cofactor. Vitamin K is used in the liver as the intermediate VKH2 to deprotonate a glutamate residue and then is reprocessed into vitamin K through a vitamin K oxide intermediate. The presence of uncarboxylated proteins indicates a vitamin K deficiency. Carboxylation allows them to bind (chelate) calcium ions, which they cannot do otherwise. Without vitamin K, blood coagulation is seriously impaired, and uncontrolled bleeding occurs. Research suggests that deficiency of vitamin K may also weaken bones, potentially contributing to osteoporosis, and may promote calcification of arteries and other soft tissues. Chemically, the vitamin K family comprises 2-methyl-1,4-naphthoquinone (3-) derivatives. Vitamin K includes two natural vitamers: vitamin K1 (phylloquinone) and vitamin K2 (menaquinone). Vitamin K2, in turn, consists of a number of related chemical subtypes, with differing lengths of carbon side chains made of isoprenoid groups of atoms. The two most studied are menaquinone-4 (MK-4) and menaquinone-7 (MK-7). Vitamin K1 is made by plants, and is found in highest amounts in green leafy vegetables, being directly involved in photosynthesis. It is active as a vitamin in animals and performs the classic functions of vitamin K, including its activity in the production of blood-clotting proteins. Animals may also convert it to vitamin K2, variant MK-4. Bacteria in the gut flora can also convert K1 into K2. All forms of K2 other than MK-4 can only be produced by bacteria, which use these during anaerobic respiration. Vitamin K3 (menadione), a synthetic form of vitamin K, was used to treat vitamin K deficiency, but because it interferes with the function of glutathione, it is no longer used in this manner in human nutrition.
In connection with: Vitamin K
Description combos: two and bacteria of It indicates which photosynthesis of
George W. Bush's tenure as the 43rd president of the United States began with his first inauguration on January 20, 2001, and ended on January 20, 2009. Bush, a Republican from Texas, took office following his narrow electoral college victory over Democratic incumbent vice president Al Gore in the 2000 presidential election. Four years later, in the 2004 presidential election, he narrowly defeated Democratic nominee John Kerry, to win re-election. Alongside Bush's presidency, the Republican Party also held their majorities in the House of Representatives under Speaker Dennis Hastert and the Senate under Senate Majority Leader Bill Frist during the 108th and 109th U.S. Congress. Bush served two terms and was succeeded by Democrat Barack Obama, who won the 2008 presidential election. He is the eldest son of the 41st president, George H. W. Bush. A decisive event reshaping Bush's administration were the terrorist attacks on September 11, 2001. In its aftermath, Congress created the Department of Homeland Security and Bush declared a global war on terrorism. He ordered an invasion of Afghanistan in an effort to overthrow the Taliban, destroy al-Qaeda, and capture Osama bin Laden. He also signed the controversial Patriot Act in order to authorize surveillance of suspected terrorists. In 2003, Bush ordered an invasion of Iraq, alleging that the Saddam Hussein regime possessed weapons of mass destruction. Intense criticism came when neither WMD stockpiles nor evidence of an operational relationship with al-Qaeda were found. Before 9/11, Bush had pushed through a $1.3 trillion tax cut program and the No Child Left Behind Act, a major education bill. He also pushed for socially conservative efforts, such as the Partial-Birth Abortion Ban Act and faith-based welfare initiatives. Also in 2003, he signed the Medicare Prescription Drug, Improvement, and Modernization Act, which created Medicare Part D. During his second term, Bush reached multiple free trade agreements and successfully nominated John Roberts and Samuel Alito to the Supreme Court. He sought major changes to Social Security and immigration laws, but both efforts failed. The wars in Afghanistan and Iraq continued, and in 2007 he launched a surge of troops in Iraq. The Bush administration's response to Hurricane Katrina and the dismissal of U.S. attorneys controversy came under attack, with a drop in his approval ratings. The 2008 financial crisis dominated his last days in office as policymakers looked to avert a major economic disaster, and he established the Troubled Asset Relief Program (TARP) to buy toxic assets from financial institutions. At various points in his presidency, Bush was among both the most popular and unpopular presidents in U.S. history. He received the highest recorded approval ratings in the wake of the September 11 attacks, but also one of the lowest such ratings during the Iraq War and the 2008 financial crisis. Although public sentiment of Bush has improved since he left office, his presidency has generally been rated as below-average by scholars.
In connection with: Presidency of George W. Bush
Title combos: Bush Presidency George of Presidency Presidency of George Bush
Description combos: tenure such on Behind the and nor an and
List of country music performers
This is an alphabetical list of country music performers. It includes artists who played country music at some point in their career, even if they were not exclusively country music performers.
In connection with: List of country music performers
Title combos: music performers List performers country country List of music
Description combos: career an country not artists music some artists It
Immunoglobulin G (IgG) is a type of antibody. Representing approximately 75% of serum antibodies in humans, IgG is the most common type of antibody found in blood circulation. IgG molecules are created and released by plasma B cells. Each IgG antibody has two paratopes.
In connection with: Immunoglobulin G
Description combos: Immunoglobulin type type antibody found plasma antibodies Immunoglobulin circulation
List of The New Yorker contributors
A list of current and past contributors to The New Yorker, along with the dates they were published and their primary areas of interest.
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Title combos: Yorker The List contributors of Yorker New The of
Description combos: The list list along of current were primary areas
William King McAlister Jr. (July 4, 1850 – May 16, 1923) was a justice of the Tennessee Supreme Court from 1893 to 1910. He was appointed by Tennessee governor Peter Turney April 1, 1893 to fill the vacancy caused by the resignation of Horace H. Lurton. He was elected in 1894 and 1902, serving until 1910. McAlister was born in Nashville, and attended Bethany College in West Virginia, enrolling at the age of 15. He served as city attorney of Nashville from 1875 to 1883. He was circuit judge of Seventh Circuit from 1886 to 1893. After leaving the Tennessee Supreme Court in 1910 he taught law at Vanderbilt University from 1910 until his death. His son Hill McAlister went on to become governor of Tennessee.
In connection with: William King McAlister
Title combos: King William William King McAlister
Description combos: After taught governor 1893 King the Virginia and McAlister
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