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Tablets, , mg: white to yellowish in color, rounded, flat, in the form of a clover leaf with beveled edges, with cross-shaped fault lines on both sides and 4 notches on the side surface, with a smooth surface, intact edges and a uniform appearance. Absorption-slow, but complete food intake does not significantly affect the speed and degree of absorption. After a single dose tablets C max is achieved after 32 h. Concentrations of carbamazepine Apparent V d — 0. Penetrates through the placental barrier. It is metabolized in the liver, mainly by the epoxy pathway, with the formation of the main metabolites: active carbamazepine,epoxide and inactive conjugate with glucuronic acid. The main isoenzyme that provides the biotransformation of carbamazepine into carbamazepine As a result of these metabolic reactions, the metabolite 9-hydroxy-methylcarbamoylacridane is also formed, which has a weak pharmacological activity. Carbamazepine can induce its own metabolism. There is no evidence that the pharmacokinetics of carbamazepine changes in elderly patients. Antiepileptic agent dibenzazepine derivative , which also has an antidepressant, antipsychotic and antidiuretic effect, has an analgesic effect in patients with neuralgia. The mechanism of action is blockade of voltage-dependent sodium channels, resulting in stabilization of overexcited neurons membranes, inhibition of the emergence of serial bits of neurons and decrease of synaptic conduction of impulses. Reduces the release of the excitatory neurotransmitter amino acid glutamate, increases the reduced CNS convulsive threshold, and thus reduces the risk of developing an epileptic attack. It is effective for focal partial epileptic attacks simple and complex , accompanied or not accompanied by secondary generalization, for generalized tonic-clonic epileptic attacks, as well as for a combination of these types of attacks usually ineffective for small attacks- petit mal , absences and myoclonic attacks. Patients with epilepsy especially children and adolescents have a positive effect on the symptoms of anxiety and depression, as well as a decrease in irritability and aggression. The effect on cognitive function and psychomotor performance depends on the dose. The onset of the anticonvulsant effect varies from several hours to several days sometimes up to 1 month due to auto-induction of metabolism. In essential and secondary trigeminal neuralgia, carbamazepine in most cases prevents the appearance of pain attacks. Easing of pain in trigeminal neuralgia is noted after hours. When alcohol withdrawal syndrome increases the threshold of convulsive readiness, which in this state is usually reduced, and reduces the severity of clinical manifestations of the syndrome increased excitability, tremor, gait disorders. Antipsychotic antimaniacal action develops after days, may be due to inhibition of the metabolism of dopamine and norepinephrine. Prolonged dosage form provides maintenance of a more stable concentration of carbamazepine in the blood when taken times a day. Caution: decompensated congestive heart failure; hyponatremia breeding syndrome hypersecretion of ADH, hypopituitarism, hypothyroidism, adrenal insufficiency ; failure of the liver and kidneys; old age; active alcoholism increases CNS depression, increased metabolism of carbamazepine ; oppression kostnomozgovy blood on a background of reception of drugs in history ; hyperplasia of prostate; increased IOP; combination with sedative-hypnotics. For women of reproductive age, if possible, Finlepsin retard is prescribed as monotherapy, in the minimum effective dose, since the frequency of congenital anomalies of newborns from mothers who took combined antiepileptic treatment is higher than with monotherapy. When pregnancy occurs, it is necessary to compare the expected benefit of therapy and possible complications, especially in the first trimester of pregnancy. It is known that children of mothers suffering from epilepsy are predisposed to disorders of intrauterine development, including malformations. Finlepsin retard can increase the risk of these disorders. There are isolated reports of cases of congenital diseases and malformations, including non-infection of the vertebral arches spina bifida. Antiepileptic drugs increase folic acid deficiency, often observed during pregnancy, which can contribute to an increase in the frequency of birth defects in children, so before the planned pregnancy and during pregnancy, folic acid is recommended. In order to prevent hemorrhagic complications in newborns, women in the last weeks of pregnancy, as well as newborns, are recommended to prescribe vitamin K. Carbamazepine penetrates into breast milk, so it is necessary to compare the benefits and possible undesirable consequences of breastfeeding in conditions of ongoing therapy. If you continue breastfeeding while taking the drug, you should monitor the child for possible adverse reactions for example, severe drowsiness, allergic skin reactions. Inside , during or after a meal, with a sufficient amount of liquid. For ease of use, the tablet as well as its half or quarter can be pre-dissolved in water or juice, since the property of prolonged release of the active substance after dissolving the tablet in the liquid remains. In cases where this is possible, Finlepsin retard should be prescribed as monotherapy. Treatment begins with a small daily dose, which is then slowly increased until the optimal effect is achieved. The addition of the drug Finlepsin retard to the already ongoing antiepileptic therapy should be carried out gradually, while the doses of the drugs used do not change or, if necessary, correct. If the patient forgot to take the next dose of the drug in a timely manner, you should take the missed dose as soon as this omission was noticed, and you can not take a double dose of the drug. The duration of use depends on the indication and the individual response of the patient to treatment. The decision to transfer the patient to Finlepsin retard, the duration of its use and the cancellation of treatment is made by the doctor individually. The possibility of reducing the dose of the drug or stopping treatment is considered after a year period of complete absence of seizures. Treatment is stopped, gradually reducing the dose of the drug for years, under the control of EEG. In children, reducing the daily dose of the drug should take into account the increase in body weight with age. After that, a certain number of patients can continue treatment with a lower maintenance dose of mg. Elderly patients and patients sensitive to carabamazepine, Finlepsin retard is prescribed at an initial dose of mg 1 time per day. The average daily dose is mg in the morning and mg in the evening. In exceptional cases, Finlepsin retard can be prescribed at a dose of mg 2 times a day. The average daily dose is mg mg in the morning and mg in the evening. If necessary, Finlepsin retard can be combined with other substances used for the treatment of alcohol abstinence, in addition to sedatives and hypnotics. During treatment, it is necessary to regularly monitor the content of carbamazepine in the blood plasma. In connection with the possible development of side effects from the Central and autonomic nervous system, patients are carefully monitored in a hospital. If necessary, the dose can be increased to mg 2 times a day. The development of adverse reactions from the Central nervous system may be the result of a relative overdose of the drug or significant fluctuations in the concentration of carbamazepine in blood plasma. CNS: frequently — dizziness, ataxia, drowsiness, weakness, headache, paresis of accommodation; sometimes abnormal involuntary movements e. The role of the drug in the development of malignant neuroleptic syndrome, especially in combination with neuroleptics, remains unclear. Allergic reactions: often — rash; sometimes — erythroderma, multi-organ hypersensitivity reaction of the delayed type with fever, skin rash, vasculitis including erythema nodosum as a manifestation of cutaneous vasculitis , lymphadenopathy, symptoms resembling lymphoma, a arthralgia, leukopenia, eosinophilia, hepatosplenomegaly and altered liver function tests these manifestations occur in various combinations. Other organs may also be involved e. From the hematopoietic organs: often-leukopenia, thrombocytopenia, eosinophilia; rarely-leukocytosis, lymphadenopathy, folic acid deficiency, agranulocytosis, aplastic anemia, true erythrocyte aplasia, megaloblastic anemia, acute intermittent porphyria, reticulocytosis, hemolytic anemia, splenomegaly. From the digestive system: often — nausea, vomiting, dry mouth, increased activity of GGT due to the induction of this enzyme in the liver , which usually has no clinical significance, increasing the activity of alkaline phosphatase; sometimes — increased activity of hepatic transaminases, diarrhea or constipation, abdominal pain; rarely glossitis, gingivitis, stomatitis, pancreatitis, hepatitis of cholestatic, parenchymal hepatocellular type, jaundice, granulomatous hepatitis, hepatic failure. On the part of the CCC: rarely-violations of intracardiac conduction; decrease or increase in blood pressure, bradycardia, arrhythmias, AV block with fainting, collapse, aggravation or development of CHF, exacerbation of IHD including the appearance or increase in angina attacks , thrombophlebitis, thromboembolic syndrome. From the musculoskeletal system: rarely-arthralgia, myalgia or convulsions. From the sensory organs: rare — disorders of taste sensations, increased IOP; cataract, conjunctivitis; hearing disorders, including tinnitus, hyperacusis, hypacusia, change of pitch perception. Other: violation of skin pigmentation, purpura, acne, hyperhidrosis, alopecia. Simultaneous administration of carbamazepine with SUR3A4 inhibitors can lead to an increase in its concentration in blood plasma and the development of adverse reactions. The combined use of inducers of CYP3A4 may lead to acceleration of the metabolism of carbamazepine, reducing its concentration in plasma and reduce therapeutic effect; on the contrary, their removal may reduce the rate of biotransformation of carbamazepine and increase its concentration. Increase the concentration of carbamazepine in plasma verapamil, diltiazem, felodipine, dextropropoxifen, viloxazine, fluoxetine, fluvoxamine, cimetidine, acetazolamide, danazol, desipramine, nicotinamide in adults, only in high doses ; macrolides erythromycin, josamycin, clarithromycin, troleandomycin ; azoles Itraconazole, ketoconazole, fluconazole , terfenadine, loratadine, isoniazid, propoxifen, grapefruit juice, viral protease inhibitors used in the treatment of HIV infection for example, ritonavir -correction of the dosage regimen or monitoring of the concentration of carbamazepine in plasma is required. Felbamate reduces the concentration of carbamazepine in plasma and increases the concentration of carbamazepine The concentration of carbamazepine is reduced by phenobarbital, phenytoin, primidone, metsuximide, fensuximide, theophylline, rifampicin, cisplatin, doxorubicin, possibly clonazepam, valpromide, valproic acid, oxcarbazepine and herbal preparations containing Hypericum perforatum. There is a possibility of replacing carbamazepine with valproic acid and primidone from the connection with plasma proteins and increasing the concentration of the pharmacologically active metabolite carbamazepine With the combined use of Finlepsin with valproic acid, in exceptional cases, coma and confusion may occur. There is a possibility to increase or decrease the level of phenytoin in blood plasma against the background of carbamazepine and improve mephenytoin. With simultaneous use of carbamazepine and lithium preparations, the neurotoxic effects of both active substances may increase. Tetracyclines can weaken the therapeutic effect of carbamazepine. When used together with paracetamol, the risk of its toxic effects on the liver increases and the therapeutic effectiveness decreases acceleration of paracetamol metabolism. Simultaneous administration of carbamazepine with phenothiazine, pimoside, thioxanthenes, molindone, haloperidol, maprotilin, clozapine, and tricyclic antidepressants leads to an increased depressive effect on the Central nervous system and a weakening of the anticonvulsant effect of carbamazepine. MAO inhibitors increase the risk of developing hyperpyretic crises, hypertensive crises, convulsions, and death before prescribing carbamazepine, MAO inhibitors should be canceled at least 2 weeks or, if the clinical situation allows, even for a longer period. Simultaneous administration with diuretics hydrochlorothiazide, furosemide can lead to hyponatremia, accompanied by clinical manifestations. Reduces the effects of non-depolarizing muscle relaxants pankuronia. Myelotoxic drugs increase the manifestations of hematotoxicity of the drug. Accelerates the metabolism of indirect anticoagulants, hormonal contraceptives, folic acid; praziquantel, can enhance the elimination of thyroid hormones. Accelerates the metabolism of drugs for anesthesia enfluran, halotan, fluorotan and increases the risk of hepatotoxic effects; increases the formation of nephrotoxic metabolites of methoxifluran. Increases the hepatotoxic effect of isoniazid. Symptoms usually reflect disorders of the Central nervous system, CNS, and respiratory system. CNS and sensory organs -depression of CNS functions, disorientation, drowsiness, excitement, hallucinations, coma; blurred vision, slurred speech, dysarthria, nystagmus, ataxia, dyskinesia, hyperreflexia at the beginning , hyporeflexia later , convulsions, psychomotor disorders, myoclonus, hypothermia, mydriasis. Digestive system — nausea and vomiting, delayed evacuation of food from the stomach, decreased motility of the colon. Urinary system -urinary retention, oliguria or anuria; fluid retention; hyponatremia. Laboratory parameters — leukocytosis or leukopenia, hyponatremia, possible metabolic acidosis, possible hyperglycemia and glucosuria, increase in the muscle fraction of CKD. Treatment: there is no specific antidote. Symptomatic maintenance treatment in the intensive care unit, monitoring of heart function, body temperature, corneal reflexes, kidney and bladder function, and correction of electrolyte disorders are required. It is necessary to determine the concentration of carbamazepine in plasma to confirm poisoning with this drug and assess the degree of overdose, gastric lavage, and the appointment of activated carbon. Late evacuation of gastric contents can lead to delayed absorption on the 2nd and 3rd days and repeated appearance of symptoms of intoxication during recovery. Forced diuresis, hemodialysis, and peritoneal dialysis are ineffective; however, dialysis is indicated when severe poisoning and renal failure are combined. Children may be in need of blood transfusion. Monotherapy for epilepsy begins with a low initial dose, gradually increasing it until the desired therapeutic effect is achieved. When selecting the optimal dose, it is advisable to determine the concentration of carbamazepine in blood plasma, especially in combination therapy. In some cases, the optimal dose may deviate significantly from the recommended initial and maintenance dose, for example, due to the induction of microsomal liver enzymes or due to interactions in combination therapy. If necessary, it can be combined with other substances used for the treatment of alcohol withdrawal. In connection with the development of side effects from the Central and autonomic nervous system, patients are carefully monitored in a hospital. When transferring the patient to carbamazepine, the dose of the previously prescribed antiepileptic agent should be gradually reduced until it is completely canceled. Sudden discontinuation of carbamazepine may trigger epileptic seizures. If it is necessary to abruptly interrupt treatment, the patient should be transferred to another antiepileptic agent under the cover of the drug shown in such cases for example, diazepam, intravenous or rectally, or phenytoin, intravenous. Before prescribing carbamazepine and during treatment, it is necessary to study liver function, especially in patients with a history of liver diseases, as well as in elderly patients. In the event of an increase in existing liver disorders or the appearance of an active liver disease, the drug should be immediately discontinued. Before starting treatment, it is necessary to conduct a study of the blood picture including counting platelets, reticulocytes , the level of iron in the blood serum, General urine analysis, urea level in the blood, EEG, determination of the concentration of electrolytes in the blood serum and periodically during treatment, since hyponatremia may develop. Subsequently, these indicators should be monitored weekly during the first month of treatment, and then monthly. However, before starting treatment, as well as periodically during treatment, clinical blood tests should be performed, including counting the number of platelets and possibly reticulocytes, as well as determining the level of iron in the blood serum. Non-progressive asymptomatic leukopenia does not require cancellation, but treatment should be discontinued if progressive leukopenia or leukopenia occurs, accompanied by clinical symptoms of an infectious disease. Carbamazepine should be discontinued immediately if hypersensitivity reactions or symptoms appear, presumably indicating the development of Stevens-Johnson syndrome or Lyell syndrome. Mild skin reactions isolated macular or maculopapular exanthema usually pass within a few days or weeks, even if the treatment is continued or the dose is reduced the patient should be closely monitored by a doctor at this time. It is necessary to take into account the possibility of activation of latent psychoses, and in elderly patients-the possibility of developing disorientation or psychomotor agitation. This was also confirmed by a meta-analysis of randomized clinical trials using antiepileptic drugs. Since the mechanism of suicidal attempts when using antiepileptic drugs is unknown, it is impossible to exclude their occurrence in the treatment of patients with Finlepsin. Intermenstrual bleeding may occur when oral contraceptives are used simultaneously. Carbamazepine can negatively affect the reliability of oral contraceptives, so women of reproductive age should use alternative methods of pregnancy prevention during treatment. Carbamazepine should only be used under medical supervision. It is necessary to inform patients about early signs of toxicity, as well as about symptoms from the skin and liver. The patient is informed of the need to immediately consult a doctor in case of adverse reactions such as fever, sore throat, rash, ulceration of the oral mucosa, unexplained bruising, hemorrhage in the form of petechiae or purpura. Before starting treatment, it is recommended to conduct an ophthalmological examination, including examination of the fundus and measurement of IOP. If the drug is prescribed to patients with increased IOP, constant monitoring of this indicator is required. Patients with severe cardiovascular diseases, liver and kidney damage, as well as the elderly are prescribed lower doses of the drug. Although the relationship between the dose of carbamazepine concentration and clinical efficacy or tolerability are rather insignificant, however regular determination of the level of carbamazepine may be useful in the following situations: the sharp increase in the frequency of attacks, and to check whether the patient the drug properly; during pregnancy; when treating children or adolescents; in suspected malabsorption drug; if you suspect the development of toxic reactions if the patient is taking several drugs. During treatment with Finlepsin, it is recommended to refrain from drinking alcohol. Tablets of prolonged action, mg, mg. Name of the legal entity in whose name the registration certificate was issued. Teva Pharmaceutical Enterprises Ltd. Send consumer complaints to the address: 35 Valovaya street, Moscow, Information about prescription drugs is for professionals only. The information provided should not be used by patients to make an independent decision on the use of the presented drugs and cannot serve as a substitute for a full-time consultation with a doctor. A description of the active substances of the drug is provided. The scientific information provided is generalized and cannot be used to decide on the possibility of using a specific drug. The appearance of the product may differ from the photos on the site. Finlepsin retard mg tbl prolong deist N50 Prescription drug. Рецептурный препарат. Product is available in pharmacies:. Add to cart. All products in the order are reserved for 24 hours, after that the order is automatically canceled. Brief information General description Manufacturer: Тева Active substance Карбамазепин There are contraindications, specialist advice is required The appearance of the product may differ from the photos on the site. Composition Long-acting tablets 1 table. Pharmacokinetics Absorption-slow, but complete food intake does not significantly affect the speed and degree of absorption. Pharmacodynamics Antiepileptic agent dibenzazepine derivative , which also has an antidepressant, antipsychotic and antidiuretic effect, has an analgesic effect in patients with neuralgia. Indications of the drug epilepsy primary generalized seizures except absences , partial forms of epilepsy simple and complex seizures , secondary generalized seizures ; trigeminal neuralgia; idiopathic glossopharyngeal neuralgia; pain with peripheral nerve damage in diabetes mellitus, pain with diabetic neuropathy; epileptiform seizures in multiple sclerosis; spasms of the facial muscles with trigeminal neuralgia; tonic convulsions, paroxysmal speech and movement disorders paroxysmal dysarthria and ataxia ; paroxysmal paresthesia and pain attacks; alcohol withdrawal syndrome anxiety, convulsions, hyperexcitability, sleep disorders ; psychotic disorders affective and schizoaffective disorders, psychoses, disorders of the limbic system. Contraindications hypersensitivity to carbamazepine and other components of the drug, as well as tricyclic antidepressants; disorders of bone marrow hematopoiesis anemia, leukopenia ; acute intermittent porphyria including anamnesis ; atrioventricular block; simultaneous administration of lithium drugs and MAO inhibitors. Use during pregnancy and lactation For women of reproductive age, if possible, Finlepsin retard is prescribed as monotherapy, in the minimum effective dose, since the frequency of congenital anomalies of newborns from mothers who took combined antiepileptic treatment is higher than with monotherapy. Dosage and administration Inside , during or after a meal, with a sufficient amount of liquid. The maximum daily dose should not exceed mg. Epilepsy In cases where this is possible, Finlepsin retard should be prescribed as monotherapy. Pain in diabetic neuropathy The average daily dose is mg in the morning and mg in the evening. Treatment of alcohol withdrawal in a hospital setting The average daily dose is mg mg in the morning and mg in the evening. Epileptiform seizures in multiple sclerosis The average daily dose is mg 2 times a day. Interaction Simultaneous administration of carbamazepine with SUR3A4 inhibitors can lead to an increase in its concentration in blood plasma and the development of adverse reactions. Carbamazepine reduces the tolerance of ethanol. Overdose Symptoms usually reflect disorders of the Central nervous system, CNS, and respiratory system. Respiratory system -respiratory depression, pulmonary edema. Special instruction Monotherapy for epilepsy begins with a low initial dose, gradually increasing it until the desired therapeutic effect is achieved. Finlepsin should not be combined with sedative hypnotics. Form release Tablets of prolonged action, mg, mg. Conditions of supply of pharmacies By prescription. Производитель Тева. Prescription drug. Available in another region. Карбамазепин мг тбл N The goods are available in pharmacies:. Финлепсин ретард мг тбл пролонг дейст N Town Pharmacy Catalog Basket 0. All pharmacies 1 Kantemirova Street Ajbolit с 8. Chigiri Social pharmacy с 8. Novotroitskoe Perekrestok pharmacy с 9. Ignatievskoe Tvoyaapteka с 8. Ignatievskoe Social pharmacy с 8.

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