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Clinical and basic research demonstrates that the endothelium plays a crucial role in mediating homeostasis and is involved in virtually every disease, either as a primary determinant of pathophysiology or as a victim of collateral damage. The endothelium is involved in the maintenance of normal organs and vascular structure and function. It may be thought as an organ by itself. Following its abnormalities in function would provide a tremendous opportunity to inform about the status of the disease progression. As it is widely distributed and easily accessible, it may be regarded as critical target in the fight against some cardio-neuro-vascular diseases. Our project aims to improve endothelium knowledge, to understand how endothelium interacts with its microenvironment, to use it as a early marker of pathological conditions and to treat its dysfunction. Inserm U - Biology of Cardiovascular Diseases. Planar cell polarity genes frizzled4 and frizzled6 exert patterning influence on arterial vessel morphogenesis by Laure PENIGAUD 2 March Publications 0 Comments Quantitative analysis of the vascular network anatomy is critical for the understanding of the vasculature structure and function. In this study, we have combined microcomputed tomography microCT and computational analysis to provide quantitative three-dimensional Maintenance of the endothelial cell barrier depends on the integrity of intercellular junctions, which is regulated by a polarity complex that includes the zeta isoform of atypical protein kinase C Vessel formation requires precise orchestration of a series of morphometric and molecular events controlled by a multitude of angiogenic factors and morphogens. In this study, we Impaired Hedgehog signalling-induced endothelial dysfunction is sufficient to induce neuropathy: In the present paper, we have identified the role of Hedgehog Hh signalling in Magellan, Pessac Phone:
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Inserm U1034 - Biology of Cardiovascular Diseases
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