Urine Collection Devices
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Colli-Pee: An innovative solution for non-invasive urine collection and stabilization
Colli-Pee®, the heart of the company, is a patented award-winning urine collection device. Colli-Pee® allows for volumetric and standardized first-void urine collection and stabilization. Urine collected with a Colli-Pee® offers improved diagnostic accuracy and patient comfort compared to a regular urine cup. The platform consists of variants collecting different volumes (4 mL to 45 mL*) for various application purposes.
Urine sampling offers several benefits, however, not all urine fractions are the same. First-void urine is generally considered the first 20mL to 30mL of urine flow. This fraction contains higher concentrations of analytes associated with Human Papillomavirus (HPV) and Chlamydia trachomatis (CT) DNA than subsequent fractions. Additionally, first-void urine sampling is important to identify cancer biomarkers, such as prostate cancer.
Collecting a first-void urine sample with a standard urine cup can be awkward, messy and inconvenient for the user. For this reason, Novosanis developed Colli-Pee®.
Urinary analytes are susceptible to enzymatic and chemical degradation. Additionally, in the time between urine collection and processing, analytes can be degraded. Consequently, methods to stabilize urine samples are necessary. The Colli-Pee® device architecture enables immediate mixing of the sample with a urine preservative, improving stability of the urine specimen.
Colli-Pee® can be prefilled with Novosanis’ Urine Conservation Medium (UCM), to allow preservation of DNA in urine. Colli-Pee containing UCM has been CE-IVD marked, and has been registered in several countries outside of Europe.
To extend the preservation coverage to other analytes (RNA, EV, cfDNA) a new preservative, Urinary Analyte Stabilizer (UAS) is currently in development.
Prototypes are available for evaluation purposes. Contact us to know more.
Optimal preservative to sample ratio depends on the type of preservative.
Our data shows:
Colli-Pee® 20 mL allows for standardized and volumetric urine collection of the first 20mL of urine flow. This has applications in infectious diseases and oncology. Collector tubes can be pre-filled with a preservative for different urinary analytes, improving transport and storage of urine at room temperature.
Colli-Pee® Small Volumes tubes are compatible with high-throughput instruments and can streamline the pre-analytical process, shorten turnaround time, minimize errors as well as reduce costs. Collector tubes can be pre-filled with a preservative for different urinary analytes, improving transport and storage of urine at room temperature.
For detection and monitoring of cancers, as well as new biomarker development, a larger volume of urine can be required. Additionally, Colli-Pee® Large Volumes supports multi-omics research. Collector tubes can be pre-filled with a preservative for different urinary analytes, improving transport and storage of urine at room temperature.
Currently, the Colli-Pee Large Volumes variant is in development.
Novosanis is working on Colli-Pee® in a box for easy home-based urine collection. The kit allows postal delivery at home, next to postal shipment of the urine sample to the lab.
*Some Novosanis products are in development or not available in all geographic regions. Contact us to know the registration status in your region.
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