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The ambition of the research group in Pharmaceutical Technology is to conduct methodological and basic mechanistic research that can contribute to the development of better and more cost effective pharmaceuticals. We will develop firstly, new and improved drug delivery solutions and secondly, formulation tools for a more effective development and manufacturing of drug products. The core expertise of the group is powder science and technology which is a scientific discipline with applications to different type of products, including pharmaceuticals. An important and common research question for the research projects of the group is how critical properties of particles and particle systems can be assessed, controlled and predicted. The main applications of the research are formulation of medicines for peroral and pulmonary administration. Three research projects are currently developed within the group, i. Tablets are typically fabricated by confined powder compression using tablet tooling of different types. Due to the application of force by the tableting punches, the volume of the powder held in the die is reduced until at coherent tablet of required fracture strength, attrition resistance and porosity is formed. Mechanical strength is hence a fundamental quality attribute of tablets and the ability of the powder to cohere into a tablet must be controlled. The powder compression event involves a series of physical phenomena on the particle level which are expressed during a short period of time. Particles constituting the powder are typically of varying size, shape and porosity and are hence difficult to reproducibly characterize as single particles. An alternative is to derive particle properties from powder compression data and the term analytical powder compression has been coined for such an approach. Analytical powder compression APC is defined as the determination of compression parameters as firstly, indications of the mechanical and friction properties of particles and secondly, as predictors of the ability of the powder to form tablets. The research group has developed a protocol for APC and is now further developing this protocol in terms of the assessment of elastic particle properties and the prediction of powder tabletability and compactibility. Poorly soluble drugs, such a BCS class II drugs, are typically used in drug products as micronized particles. In order to enable tablet manufacturing of such fine particulate material, the particles are often pre-processed by a size enlargement process during which a granular powder is prepared which consists of granules considerably larger than the starting material. An emerging granulation technology for large scale tablet manufacturing is dry granulation by roll compaction, a technology suitable for continuous manufacturing. The research group studies how physical and technical properties of the granules are affected by variations in powder composition and process parameters. The aim is to derive a mechanistic understanding of the compression properties of the granules enabling a rational approach to their formulation. The approach used in these studies is the sequential relationship composition — microstructure — single granule mechanics - tableting performance. Both traditional granules and model granules of uniform size and shape are used in research. Different types of dosage forms are used to deliver drugs to the lung och among these, inhalations powders are common due to their patient friendly properties. In order for particles to be inhalable and be deposited in the lung, they have to be very fine with an aerodynamic particle diameter typically below 5 mm. To enable automated machine filling of the inhaler as well as emptying of the inhaler and subsequent particle aerosolization during use, the micronized particles usually have to be agglomerated. Examples of two different types of agglomerates used in drug products, which hence represents important formulation technologies for inhalation powders, are adhesive mixtures structured agglomerates and soft non-structured agglomerates. In the research group, physical and formulation properties of agglomerates for inhalation are studied, primarily adhesive mixtures. A classification system, denoted a blend state theory, of adhesive mixtures has been introduced and the impact of blend state on powder physico-technical and aerosolisation properties has been demonstrated for different carriers and drugs. With this conceptual description as starting position work is on-going how the blend state can be controlled as well as the possibility to affect the interparticulate forces acting in the blend. Effect of drug load on the aerosolisation propensity of binary adhesive mixtures for inhalation. Part of International Journal of Pharmaceutics, Tabletability and compactibility of alpha-lactose monohydrate powders of different particle size. II: predicted relationships. Part of Pharmaceutical development and technology Print , p. Experimental comparison. Effect of fluid velocity and particle size on the hydrodynamic diffusion layer thickness. Andersson, Sara B. Part of European journal of pharmaceutics and biopharmaceutics, p. Effect of pressure drop on the in vitro dispersion of adhesive mixtures of different blend states for inhalation. Effects of a novel weight-loss combination product containing orlistat and acarbose on obesity: A randomized, placebo-controlled trial. Part of Obesity, p. Effect of excipient properties and blend ratio on the compression properties of dry granulated particles prepared from microcrystalline cellulose and lactose. Part of Powder Technology, Deciphering the role of granule deformation and fragmentation for the tableting performance of some dry granulated powders. On the relationship between blend state and dispersibility of adhesive mixtures containing active pharmaceutical ingredients. Part of Clinical Pharmacology in Drug Development, p. Part of Pharmaceutics, Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity. Crack nucleation and propagation in microcrystalline-cellulose based granules subject to uniaxial and triaxial load. Part of International Journal of Pharmaceutics, p. Evaluation of bulk compression using a discrete element procedure calibrated with data from triaxial experiments on single particles. Part of Powder Technology, p. Linking carrier morphology to the powder mechanics of adhesive mixtures for dry powder inhalers via a blend-state model. Atypical compaction behaviour of disordered lactose explained by a shift in type of compact fracture pattern. Milling induced amorphisation and recrystallization of alpha-lactose monohydrate. A hybrid approach to predict the relationship between tablet tensile strength and compaction pressure using analytical powder compression. Effect of milling on the plastic and the elastic stiffness of lactose particles. Part of European Journal of Pharmaceutical Sciences, p. Part of Journal of Pharmaceutical Sciences, p. Determination of interfacial amorphicity in functional powders. Relationships between surface coverage ratio and powder mechanics of binary adhesive mixtures for dry powder inhalers. Compressibility and tablet forming ability of bimodal granule mixtures: Experiments and DEM simulations. Determination of Interfacial Amorphicity in Functional Powders. Part of Langmuir, p. Comminution-amorphisation relationships during ball milling of lactose at different milling conditions. Powder compression mechanics of spray-dried lactose nanocomposites. Considerations on the quantitative analysis of apparent amorphicity of milled lactose by Raman spectroscopy. Compression analysis for assessment of pellet plasticity: Identification of reactant pores and comparison between Heckel, Kawakita, and Adams equations. An apparatus for confined triaxial testing of single particles. The crystallinity of cellulose controls the physical distribution of sorbed water and the capacity to present water for chemical degradation of a solid drug. The degree of compression of spherical granular solids controls the evolution of microstructure and bond probability during compaction. Effect of degree of methoxylation and particle size on compression properties and compactibility of pectin powders. An experimental evaluation of an effective medium based compaction equation. A protocol for the classification of powder compression characteristics. Gel formulations containing catanionic vesicles composed of alprenolol and SDS: effects of drug release and skin penetration on aggregate structure. Part of Colloids and Surfaces B, p. Flowability of surface modified pharmaceutical granules: A comparative experimental and numerical study. Degree of compression as a potential process control tool of tablet tensile strength. Effect of spherical-agglomerate strength on the distribution of force during uniaxial compression. A statistical approach to evaluate the potential use of compression parameters for classification of pharmaceutical powder materials. Effect of lubrication on the distribution of force between spherical agglomerates during compression. Dry mixing transformed micro-particles of a drug from a highly crystalline to a highly amorphous state. On the physical interpretation of the initial bending of a Shapiro-Konopicky-Heckel compression profile. Clinical study shows improved absorption of desmopressin with novel formulation. Part of Pharmaceutical research, p. Effective Kawakita parameters for binary mixtures. A particle rearrangement index based on the Kawakita powder compression equation. Uppsala University Subpages for Uppsala University. Study Subpages for Study. Research Subpages for Research. Neuropharmacology and biological addiction research. Pharmaceutical Bioinformatics. Pharmaceutical cellbiology. Pharmaceutical Physics. Pharmaceutical Technology. Spatial Mass Spectrometry. Translational Drug Discovery and Development. About us Subpages for About us. Description The ambition of the research group in Pharmaceutical Technology is to conduct methodological and basic mechanistic research that can contribute to the development of better and more cost effective pharmaceuticals. Learn more about our research areas. Analytical powder compression Tablets are typically fabricated by confined powder compression using tablet tooling of different types. Formulation of dry granulated powders Poorly soluble drugs, such a BCS class II drugs, are typically used in drug products as micronized particles. Formulation of inhalation powders Different types of dosage forms are used to deliver drugs to the lung och among these, inhalations powders are common due to their patient friendly properties. To top.

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Uppsala buy powder

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