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After ingestion, it reaches the large intestine without significant absorption, where it is split under the action of bacterial flora to form the active form — bis - p-hydroxyphenyl -pyridylmethane. The laxative effect develops hours after administration, the severity of the laxative effect does not correlate with the level of active bis- p-hydroxyphenyl -pyridylmethane in the blood plasma. It is not subjected to hepatic-intestinal recycling. A contact laxative of the triarylmethane group, activated in the large intestine under the action of bacterial sulfatases; the substance that is released in this case, stimulates the sensitive nerve endings of the intestinal mucosa, increases its motility. The use of the drug is not accompanied by tenesmus and intestinal spasms. In exchange treatment Muttasil stimulates the growth and metabolic activity of normal intestinal microflora. Constipation or cases requiring relief of defecation hemorrhoids, proctitis, anal fissures, preparation for surgery, instrumental and x-ray examinations. With caution: elderly patients, hypokalemia, high magnesium content in the blood, patients with asthenia, II-III trimesters of pregnancy. The safety of use during pregnancy and lactation has not been studied. In the first trimester of pregnancy, the drug is contraindicated. In the II—III trimesters of pregnancy, the use of the drug is possible only if the intended benefit to the mother exceeds the possible risk to the fetus. Sodium picosulfate is not excreted in breast milk, but if you need to use the drug Guttasil during lactation, you should stop breastfeeding. Adults and children older than 10 years — drops mg ; children from 4 to 10 years — drops 2. Children can add the drug to their food. In children, a single dose of the drug is effective. If necessary, the course of treatment for the child can be extended, but it is preferable to limit it to three days. To eliminate constipation in cancer patients receiving large doses of opioids, it is used as prescribed by a doctor. With long-term use of the drug in significantly increased doses, the following violations are possible. From the water-electrolyte balance: loss of potassium, sodium and other electrolytes, possible development of dehydration. On the part of the digestive system: dyspeptic phenomena, vomiting, nausea, cramps and abdominal pain, diarrhea, flatulence, pain in the stomach and anus, increased intestinal motility, which pass with a decrease in the dose of the drug. From the Central nervous system: headache, fatigue, drowsiness, convulsions. Electrolyte imbalance can lead to a decrease in tolerance to cardiac glycosides. Diuretics or corticosteroids may increase the severity of hypokalemia caused by the use Muttasil in high doses. Simultaneous treatment with antibiotics can reduce the laxative effect of the drug. Symptoms: high doses of Guttasil can cause liquid bowel movements, abdominal cramps colic , and clinically significant water-electrolyte balance disorders hypokalemia, loss of other electrolytes and fluid , and ischemia of the colon mucosa. Prolonged overdose leads to the development of chronic diarrhea and abdominal pain, hypokalemia, secondary hyperaldosteronism, possible kidney damage and the development of nephrolithiasis, metabolic alkalosis, hypokalemia and muscle weakness as a result of hypokalemia. Treatment: gastric lavage, administration of enterosorbents activated carbon , symptomatic treatment correction of water-electrolyte balance, appointment of antispasmodics. Like other laxatives, Guttasil should not be taken daily for a long time. If you need to take laxatives daily, you should find out the cause of constipation. Prolonged use of laxatives can lead to electrolyte imbalance and hypokalemia, as well as cause addiction and constipation due to the ricochet effect. Muttasil effective in relieving constipation in cancer patients receiving high doses of opioids. The drug contains sorbitol, so patients with rare hereditary fructose intolerance are not recommended to take it. Influence on the ability to drive vehicles and work with mechanisms. In therapeutic doses, the drug does not affect the ability to drive vehicles and work with other mechanisms. Drops for oral administration, 7. Each bottle is placed in a pack of cardboard. Name and address of the legal entity in whose name the registration certificate was issued: PJSC Farmak. Information about prescription drugs is for professionals only. The information provided should not be used by patients to make an independent decision on the use of the presented drugs and cannot serve as a substitute for a full-time consultation with a doctor. A description of the active substances of the drug is provided. The scientific information provided is generalized and cannot be used to decide on the possibility of using a specific drug. The appearance of the product may differ from the photos on the site. Guttasil 7. Product is available in pharmacies:. Add to cart. All products in the order are reserved for 24 hours, after that the order is automatically canceled. Composition Drops for reception inside 1 ml active substance: sodium picosulfate monohydrate in terms of sodium picosulfate 7. Pharmacokinetics After ingestion, it reaches the large intestine without significant absorption, where it is split under the action of bacterial flora to form the active form — bis - p-hydroxyphenyl -pyridylmethane. Pharmacodynamics A contact laxative of the triarylmethane group, activated in the large intestine under the action of bacterial sulfatases; the substance that is released in this case, stimulates the sensitive nerve endings of the intestinal mucosa, increases its motility. Indications of the drug Constipation or cases requiring relief of defecation hemorrhoids, proctitis, anal fissures, preparation for surgery, instrumental and x-ray examinations. Contraindications hypersensitivity to sodium picosulfate and other components of the drug; intestinal obstruction; acute inflammatory bowel diseases and acute abdominal diseases including acute appendicitis, ulcerative colitis, peritonitis ; acute abdominal pain, accompanied by nausea and vomiting, which may indicate acute inflammatory diseases, severe dehydration; pregnancy I trimester ; lactation. Use during pregnancy and lactation The safety of use during pregnancy and lactation has not been studied. Dosage and administration Inside, at night so that the chair is the next morning. Side effect With short-term use of the drug, side effects are rarely observed. Skin: skin rash, hives, itching. From the immune system: allergic reactions, angioedema. Interaction Electrolyte imbalance can lead to a decrease in tolerance to cardiac glycosides. Overdose Symptoms: high doses of Guttasil can cause liquid bowel movements, abdominal cramps colic , and clinically significant water-electrolyte balance disorders hypokalemia, loss of other electrolytes and fluid , and ischemia of the colon mucosa. Special instruction Like other laxatives, Guttasil should not be taken daily for a long time. Form release Drops for oral administration, 7. Conditions of supply of pharmacies Without a prescription. Manufacturer PAO Farmak. Phone: This product is in 24 pharmacies, see all 1A Partizanskaya Street s. Ignatievskoe, Social pharmacy 17 pom Sh. This product is in 20 pharmacies, see all 1A Partizanskaya Street s. Available in another region. Town Pharmacy Catalog Basket 0. All pharmacies 1 Kantemirova Street Ajbolit с 8. Chigiri Social pharmacy с 8. Novotroitskoe Perekrestok pharmacy с 9. Ignatievskoe Tvoyaapteka с 8. Ignatievskoe Social pharmacy с 8.

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