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Трамадол Нюрнберг

Please note that all translations are automatically generated. Click here for the English version. Мы описываем микрохирургической подход к генерации артериовенозные AV петли в качестве модели для анализа васкуляризации в естественных условиях в изолированном и хорошо охарактеризованного окружающей среды. Эта модель не только полезно для исследования ангиогенеза, но и оптимально подходит для инженерных и аксиально васкуляризированных перевивных тканей. A functional blood vessel network is a prerequisite for the survival and growth of almost all tissues and organs in the human body. Moreover, in pathological situations such as cancer, vascularization plays a leading role in disease progression. Consequently, there is a strong need for a standardized and well-characterized in vivo model in order to elucidate the mechanisms of neovascularization and develop different vascularization approaches for tissue engineering and regenerative medicine. We describe a microsurgical approach for a small animal model for induction of a vascular axis consisting of a vein and artery that are anastomosed to an arteriovenous AV loop. The AV loop is transferred to an enclosed implantation chamber to create an isolated microenvironment in vivo, which is connected to the living organism only by means of the vascular axis. By implanting different cells, growth factors and matrices, their function in blood vessel network formation can be analyzed without any disturbing influences from the surroundings in a well controllable environment. In addition to angiogenesis and antiangiogenesis studies, the AV loop model is also perfectly suited for engineering vascularized tissues. After a certain prevascularization time, the generated tissues can be transplanted into the defect site and microsurgically connected to the local vessels, thereby ensuring immediate blood supply and integration of the engineered tissue. Большинство тканей и органов в организме человека зависят от функциональной сети сосудов крови, которая поставляет питательные вещества, газы и обменивает удаляет продукты жизнедеятельности. Неисправность этой системы, вызванной местными или системными проблемами сосудов может привести к множеству серьезных заболеваний. Кроме того, в научных областях, таких как тканевой инженерии или восстановительной медицины, функциональная сеть кровеносных сосудов в искусственно созданных тканей или пересаженных органов является необходимым условием для успешного клинического применения. В течение десятилетий исследователи исследовали точные механизмы, Log in or Start trial to access full content. Для экспериментов, самцов крыс линии Lewis с массой тела - использовали г. Васкуляризация вполне может быть продемонстрировано с помощью 3D микро-комп Уже более десяти лет мы успешно использовали артериовенозного AV петля для тканевой инженерии целей и изучения ангиогенеза в естественных условиях в небольшой животной модели. Можно показать, что эта микрохирургической модель очень хорошо подходит для создания модифицированны? Name Company Catalog Number Comments 0. KG P All rights reserved. Faculty Resource Center. High Schools. Sign In. JoVE Journal Bioengineering. Automatic Translation. Annika Weigand 1 , Justus P. Horch 1 , Anja M. Boos 1. Summary Мы описываем микрохирургической подход к генерации артериовенозные AV петли в качестве модели для анализа васкуляризации в естественных условиях в изолированном и хорошо охарактеризованного окружающей среды. Abstract A functional blood vessel network is a prerequisite for the survival and growth of almost all tissues and organs in the human body. Introduction Большинство тканей и органов в организме человека зависят от функциональной сети сосудов крови, которая поставляет питательные вещества, газы и обменивает удаляет продукты жизнедеятельности. Representative Results тканевая инженерия Для технических целей костной ткани, были имплантированы целый ряд различных заменителей костной ткани в небольшом животных крысы модели AV петля 27,28,33, Discussion Уже более десяти лет мы успешно использовали артериовенозного AV петля для тканевой инженерии целей и изучения ангиогенеза в естественных условиях в небольшой животной модели. References Folkman, J. Angiogenesis in vitro. DeCicco-Skinner, K. Endothelial cell tube formation assay for the in vitro study of angiogenesis. J Vis Exp. Puddu, A. Exp Eye Res. Li, H. J Cell Biochem. Griffith, L. Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol. Nehls, V. The configuration of fibrin clots determines capillary morphogenesis and endothelial cell migration. Microvasc Res. Fischbach, C. Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement. Logsdon, E. A systems biology view of blood vessel growth and remodelling. J Cell Mol Med. Kaully, T. Vascularization--the conduit to viable engineered tissues. Tissue Eng Part B Rev. Risau, W. Mechanisms of angiogenesis. Carmeliet, P. Mechanisms of angiogenesis and arteriogenesis. Nat Med. Morin, K. In vitro models of angiogenesis and vasculogenesis in fibrin gel. Exp Cell Res. Ucuzian, A. In vitro models of angiogenesis. World J Surg. Staton, C. A critical analysis of current in vitro and in vivo angiogenesis assays. Int J Exp Pathol. Tahergorabi, Z. A review on angiogenesis and its assays. Iran J Basic Med Sci. Agostini, S. Barley beta-glucan promotes MnSOD expression and enhances angiogenesis under oxidative microenvironment. Zhang, B. Zebrafish xenotransplantation as a tool for in vivo cancer study. Fam Cancer. Devaud, C. Tissues in different anatomical sites can sculpt and vary the tumor microenvironment to affect responses to therapy. Mol Ther. Min, Z. Biomater Sci. Sundaram, S. Tissue-engineered vascular grafts created from human induced pluripotent stem cells. Stem Cells Transl Med. Hori, A. Int J Oral Maxillofac Implants. Laschke, M. Prevascularization in tissue engineering: Current concepts and future directions. Biotechnol Adv. Wong, H. Novel method to improve vascularization of tissue engineered constructs with biodegradable fibers. Rouwkema, J. Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct. Tissue Eng. Lokmic, Z. Engineering the microcirculation. Erol, O. New capillary bed formation with a surgically constructed arteriovenous fistula. Surg Forum. Arkudas, A. Evaluation of angiogenesis of bioactive glass in the arteriovenous loop model. Tissue Eng Part C Methods. Axial prevascularization of porous matrices using an arteriovenous loop promotes survival and differentiation of transplanted autologous osteoblasts. Composition of fibrin glues significantly influences axial vascularization and degradation in isolation chamber model. Blood Coagul Fibrinolysis. Dose-finding study of fibrin gel-immobilized vascular endothelial growth factor and basic fibroblast growth factor in the arteriovenous loop rat model. Tissue Eng Part A. Mol Med. Buehrer, G. Kneser, U. Engineering of vascularized transplantable bone tissues: induction of axial vascularization in an osteoconductive matrix using an arteriovenous loop. Combination of extrinsic and intrinsic pathways significantly accelerates axial vascularization of bioartificial tissues. Plast Reconstr Surg. Bach, A. A new approach to tissue engineering of vascularized skeletal muscle. Bitto, F. Myogenic differentiation of mesenchymal stem cells in a newly developed neurotised AV-loop model. Biomed Res Int. Fiegel, H. Foetal hepatocyte transplantation in a vascularized AV-Loop transplantation model in the rat. Polykandriotis, E. The venous graft as an effector of early angiogenesis in a fibrin matrix. Regression and persistence: remodelling in a tissue engineered axial vascular assembly. Yuan, Q. BMC Biotechnol. Dew, L. Vascularization strategies for tissue engineers. Regen Med. Kang, Y. Engineering a vascularized collagen-beta-tricalcium phosphate graft using an electrochemical approach. Acta Biomater. Novosel, E. Vascularization is the key challenge in tissue engineering. Adv Drug Deliv Rev. Zimmerer, R. Prefabrication of vascularized facial bones. Dunda, S. Handchir Mikrochir Plast Chir. Tanaka, Y. Tissue engineering skin flaps: which vascular carrier, arteriovenous shunt loop or arteriovenous bundle, has more potential for angiogenesis and tissue generation?. Dong, Q. Prefabrication of axial vascularized tissue engineering coral bone by an arteriovenous loop: a better model. Prevascularisation strategies in tissue engineering. Mofikoya, B. Does open guide suture technique improve the patency rate in submillimeter rat artery anastomosis?. Manasseri, B. Microsurgical arterovenous loops and biological templates: a novel in vivo chamber for tissue engineering. Moimas, S. AAV vector encoding human VEGFtransduced pectineus muscular flaps increase the formation of new tissue through induction of angiogenesis in an in vivo chamber for tissue engineering: A technique to enhance tissue and vessels in microsurgically engineered tissue. J Tissue Eng. Fan, J. Microsurgical techniques used to construct the vascularized and neurotized tissue engineered bone. Bleiziffer, O. Guanylate-binding protein 1 expression from embryonal endothelial progenitor cells reduces blood vessel density and cellular apoptosis in an axially vascularised tissue-engineered construct. Horch, R. Cancer research by means of tissue engineering--is there a rationale?. Lee, H. Genetically engineered mouse models for drug development and preclinical trials. Biomol Ther Seoul. Willey, C. Semin Radiat Oncol. Guiro, K. Bioengineering Models for Breast Cancer Research. Breast Cancer Auckl. Ghajar, C. Tumor engineering: the other face of tissue engineering. Boos, A. Engineering axially vascularized bone in the sheep arteriovenous-loop model. J Tissue Eng Regen Med. Weigand, A. Acceleration of vascularized bone tissue-engineered constructs in a large animal model combining intrinsic and extrinsic vascularization. Successful human long-term application of in situ bone tissue engineering. This article has been published Video Coming Soon Keep me updated:. Contact Us. Recommend to library.

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