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Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. Members in this family been observed to produce a complex mixture of hallucinogenic , stimulant , psychedelic and entactogenic effects that qualitatively separates it from other psychedelic phenethylamine compounds like members of the 2C-x or DOx series. TMA-2 was first synthesized by Viktor Bruckner in \\\\\\\\\\\\\\\[1 \\\\\\\\\\\\\\\] , but was not investigated as a psychoactive chemical until Alexander Shulgin synthesized and tested it in \\\\\\\\\\\\\\\[2 \\\\\\\\\\\\\\\]. Shulgin published his synthesis and initial research findings in a paper, describing the effects as similar to mescaline , though lacking in color effects, producing less nausea and prone to causing anxiety and restlessness. Since then it has been regarded as an oddball and a novelty in the psychedelics community and is only occasionally sought after intentionally. In terms of its subjective effects, it is known for its lack of classic psychedelic visuals compared to its parent compound mescaline and is known instead for its instead a unique stimulating body-high and altered headspace that ranges from euphoric to dysphoric variably. Anecdotal reports suggest that TMA-2 is a highly unpredictable and dose-sensitive substance that can produce uncomfortable amounts of body load, nausea, overstimulation, and inconsistencies between experiences. In modern times, TMA-2 is used as an obscure recreational drug and a occasional entheogen. It is rarely sold on the streets and is almost exclusively obtainable as a grey area research chemical through the use of online vendors. TMA-2, or 2,4,5-trimethoxyamphetamine, is a molecule of the substituted amphetamine class. This pharmacology section is incomplete. You can help by adding to it. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive. You can help by expanding it. The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely if ever occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death. Anecdotal reports which describe the effects of this compound within our experience index include:. The toxicity and long-term health effects of recreational TMA-2 use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because TMA-2 has very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried TMA-2 suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly but nothing can be completely guaranteed. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. TMA-2 is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating. Tolerance to the effects of TMA-2 are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline in the absence of further consumption. TMA-2 presents cross-tolerance with all psychedelics , meaning that after the consumption of TMA-2 all psychedelics will have a reduced effect. As such, it may contain incomplete or wrong information. Retrieved from ' https: Psychoactive substance Research chemical Phenethylamine Psychedelic Amphetamine. Navigation menu Personal tools English Create account Log in. Views Read View source View history. Community Network Youtube Good vibes. This subjective effect breakdown is a stub. As such, it may contain incomplete or wrong information and is still in progress. This legality section is a stub.