Thymosin Beta 4 X Linked

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TMSB4X thymosin beta 4 X-linked Gene ID: 7114, updated on 1-Aug-2023 Gene type: protein coding Also known as: FX; TB4X; PTMB4; TMSB4 See all available tests in GTR for this gene Go to complete Gene record for TMSB4X Go to Variation Viewer for TMSB4X variants SummaryThymosin beta4 Suppresses LPS-Induced Murine Lung Fibrosis by Attenuating Oxidative Injury and Alleviating Inflammation. Thymosin beta4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-kappaB signaling axis in APP/PS1 mice. Discovery of thymosin beta4 as a human exerkine and growth factor. Thymosin β4 (Tβ4) is a multifunctional and widely distributed peptide that plays a pivotal role in several physiological and pathological processes in the body, namely, increasing angiogenesis and proliferation and inhibiting apoptosis and inflammation. Thymosin is a hormone secreted from the thymus; a small, irregular-shaped gland in the top part of the chest, just under the breastbone and between the lungs. The thymus is responsible for regulating the immune system and tissue repair. Thymosin Beta 4 (Tβ4) is a naturally occurring peptide made up of 43 amino acid proteins. Recommended INN for thymosin beta-4 is 'timbetasin', as published by the World Health Organization . Introduction Thymosin beta-4 Function Biological activities of thymosin β4 Actin binding "Moonlighting" Tissue regeneration Anti-inflammatory role for sulfoxide Terminal deoxynucleotidyl transferaseTmsb4x (thymosin beta-4 X-linked), Hmox1, Ifitm3, Ldhb, and Itgb7 were identified as strong candidate genes that promote metastasis. In particular, Tmsb4x enhanced DGC metastasis and stomach organoid-generated tumor growth in in vivo transplantation models. Tmsb4x promoted tumor clonogenicity and anoikis resistance. Thymosin beta‐4 (TB 4) is an X‐linked gene product with cardioprotective properties. Little is known about plasma concentration of TB 4 in heart failure ( HF ), and its relationship with other cardiovascular biomarkers. We identified thymosin beta-4 X-linked (TMSB4X) is one of the most significant candidate biomarkers. Higher TMSB4X expression in the tumor was found by N/T-paired HNSCC samples at both RNA and. Published studies have described a number of physiological properties and cellular functions of thymosin beta4 (Tbeta4), the major G-actin-sequestering molecule in mammalian cells. Those activities include the promotion of cell migration, blood vessel formation, cell survival, stem cell differentiat …Quality Chemicals For Research Used Only. Speedy Delivery. In Bulk. Call Us Now!Thymosin Beta 4 is a naturally occurring peptide. It is found in high concentrations in blood platelets, wound fluid and other tissues in the body. Tβ4 is not a growth factor; rather, it is a major actin regulating peptide. Tβ4 has been found to play an important role in protection, regeneration and remodeling of injured or damaged tissues. . Official Full Name thymosin, beta 4, X chromosome provided by MGI Primary source MGI:MGI:99510 AllianceGenome:MGI:99510 Gene type RefSeq status Organism Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus Also known asDescription TMSB4X, or thymosin beta-4, belongs to the thymosin beta family. It is an actin sequestering protein which plays an important role in the regulation of actin polymerization. TMSB4X binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Thymosin beta(4) as well as the other members of the beta-thymosin family are important G-actin sequestering peptides. The chemical properties, the biosynthesis, and posttranslational modifications (PTMs) of these peptides are discussed. During biosynthesis of thymosin beta(4) the initiator methionine is removed and the N-terminus is acetylated. Function This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y ( TMSB4Y ). [5] Biological activities of thymosin β4In vivo CRISPR-Cas9 knockout screening using quantitative PCR identifies thymosin beta-4 X-linked that promotes diffuse-type gastric cancer metastasis Gastric cancer (GC) is histologically classified into intestinal-type gastric cancer (IGC) and diffuse-type gastric cancer (DGC), and the latter is poorly differentiated and highly metastatic. Thymosin beta4 Suppresses LPS-Induced Murine Lung Fibrosis by Attenuating Oxidative Injury and Alleviating Inflammation. Circular RNA PIP5K1A (circPIP5K1A) accelerates endometriosis progression by regulating the miR-153-3p/Thymosin Beta-4 X-Linked (TMSB4X) pathway. Discovery of thymosin beta4 as a human exerkine and growth factor. thymosin beta 4, X-linked: RGD ID: 621622: Description: Predicted to enable actin monomer binding activity and enzyme binding activity. Involved in osteoblast differentiation. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Orthologous to human TMSB4X (thymosin beta 4 X-linked); INTERACTS WITH 17alpha . We identified thymosin beta-4 X-linked (TMSB4X) is one of the most significant candidate biomarkers. Higher TMSB4X expression in the tumor was found by N/T-paired HNSCC samples at both RNA and protein level. Official Full Name thymosin beta 4 X-linked provided by HGNC Primary source MIM:300159; AllianceGenome:HGNC:11881 Lineage Also known as Summary This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. Whereas thymosin β4 can augment an organism's ability to heal surface wound and stimulate angiogenesis 16,17,32, the work presented here is the first demonstration of thymosin β4's efficacy in . TB4 is strongly correlated with a cluster of 7 markers from the proximity extension assay panel, which are either X-linked, regulated by sex hormones, or involved with NF-κB signaling. Conclusions: We show that plasma TB4 is elevated in women with HFpEF and has prognostic information. Thymosin beta 4 (Tβ4) is an X-linked, small (44aa), ubiquitously expressed protein. Tβ4 has been shown to bind in a 1:1 ratio with G-actin. Cardiac-specific shRNA knockdown of t β4 , using an Nkx2. 5-cre driver in mice, resulted in abnormal development of compact myocardium and coronary vasculature and significant embryonic lethality between . TMSB4X Gene - GeneCards | TYB4 Protein | TYB4 Antibody TMSB4X Gene - Thymosin Beta 4 X-Linked Protein Coding (Updated: Aug 2, 2023 ; GC0XP012975 ; GIFtS: 44 ) Search in Gene Follow Gene Jump to section Aliases Disorders Domains Drugs Expression Function Genomics Localization Orthologs Paralogs Pathways Products Proteins Publications Sources

1. https://blog.libero.it/wp/bogdandmitrievpi/wp-content/uploads/sites/88273/2024/01/23-G-To-Tbsp.pdf


2. https://groups.google.com/g/89muscleman89/c/fdeXIy5EB-A


3. https://groups.google.com/g/escopiroli/c/yzIkezwVVZ8


4. https://publiclab.org/notes/print/44109


5. https://drive.google.com/file/d/1VP5JLai1-g8fM1nboDLdyQdZf8yLArxU/view

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