Testosterone Decanoate Male Contraception

***************************

***************************

To be successful, a male contraceptive must be effective and its effects on spermatogenesis must be reversible. . testosterone isocaproate, and testosterone decanoate (Sustanon), every 2-3 weeks. In one series of 551 injections, 162 were associated with pain and bleeding; . The administration of testosterone alone in supraphysiological doses induces azoospermia or severe oligozoospermia in a high proportion of normal men, and this has been demonstrated to result in good contraceptive efficacy [9], [10]. The absence of a long-duration preparation of testosterone remains a barrier to development. 01 February 2002 Article history PDF Split View Cite Permissions Share Suppression of spermatogenesis to azoospermia is the goal of hormonal male contraception based on T combined with gestagens. The combination of the long-acting T, ester testosterone undecanoate (TU), with norethisterone (NET) enanthate (E) showed high efficacy. INTRODUCTION Testosterone is a pleiotropic hormone that plays various physiological roles in the development of male genitalia in utero and during puberty. Classically, testosterone is a hormone associated with masculinity. The use of testosterone as a male contraceptive Testosterone functions as a contraceptive by suppressing secretion of the pituitary gonadotropins luteinizing hormone and follicle stimulating hormone. Low levels of these hormones decrease endogenous testosterone secretion from the testis and deprive developing sperm of the signals required for nor …A pilot study examined etonogestrel's potential as part of a male hormonal contraceptive regimen in combination with testosterone pellets was promising , leading to an international multicentre phase II study that enrolled 130 men and used combinations of etonogestrel implants with testosterone decanoate for 48 weeks . A total of 78-85% of . Overall, a majority of men feel that the responsibility of contraception falls too much on women ( 11) and are receptive to male-based methods ( 10 ), while 71-97% of women believe male hormonal contraception is a "good idea" ( 12 ). The time is ripe, therefore, for introduction of new methods to the marketplace. III. Testosterone decanoate has been investigated as a potential long-acting injectable male contraceptive. [4] [6] [7] [8] It has a longer duration of action than testosterone enanthate, but its duration is not as prolonged as that of testosterone undecanoate. [4] See also List of androgen esters § Testosterone esters ReferencesSperm production occurs in the seminiferous tubules, where the sperm are nurtured by Sertoli cells stimulated by follicle-stimulating hormone (FSH) and high concentrations of intra-testicular testosterone ( Figure -left panel) ( 5 ). Given the physiology of sperm production, a male contraceptive can work in one of several ways: Figure 110. 1016/s0010-7824(02)00390-6 Abstract We have investigated the pharmacokinetics and effects on the male reproductive axis of a novel preparation of testosterone decanoate (TD) with a progestogen implant. The effect of a novel combination of oral etonogestrel (ENG) and im testosterone decanoate (TD) on suppression of gonadotropins and spermatogenesis as a potential lead for male contraception was investigated. Healthy male volunteers were randomized into two groups receiving 300 μg ENG daily and 400 mg TD every 4 (n = 55) or 6 (n = 57) wk for . 11836281 10. 1210/jcem. 87. 2. 8218 Suppression of spermatogenesis to azoospermia is the goal of hormonal male contraception based on T combined with gestagens. The combination of the long-acting T, ester testosterone undecanoate (TU), with norethisterone (NET) enanthate (E) showed high efficacy. Male hormonal contraception is well tolerated and acceptable to most men. Unfortunately, testosterone-alone regimens fail to completely suppress spermatogenesis in all men, meaning that in some the potential for fertility remains. Recent findingsThe testosterone concentration achieved by exogenous testosterone for hormonal male contraceptive regimens is adequate to maintain peripheral androgen functions but is less than the high intratesticular testosterone . testosterone decanoate, 19-nortestosterone-hexoxyphenylpropionate, dimethandrolone undecanoate a: Injection — depot . Male hormonal contraceptives involve testosterone which works by reducing luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary. Hormonal male contraceptive regimens show full reversibility within a predictable time course. Various covariables affect the rate but not the extent of recovery, although their effect sizes are minor. . (intramuscular testosterone decanoate and undecanoate and subcutaneous testosterone pellets). Substantial overlap of 95% CIs for hazards . In the first, a long-acting injectable testosterone ester, testosterone decanoate, was combined with etonogestrel implants and resulted in 80-90% of subjects achieving a fewer than 1 million sperm per milliliter. . may lead to a safe, reversible and effective male contraceptive. Publication types Review MeSH terms Contraception / methods . A second progestin, desogestrel, has also been tested in male contraceptive regimens with similar results, but with less weight gain and smaller reductions in HDL cholesterol. 43 A large industry sponsored study of testosterone decanoate injections combined with an etonogestrel implant suppressed 80-90% of men below a sperm concentration of 1 . Testosterone decanoate is an androgen and anabolic steroid and a testosterone ester. It is a component of Sustanon, along with testosterone propionate, testosterone phenylpropionate, and testosterone isocaproate. The medication has not been marketed as a single-drug preparation. Testosterone decanoate has been investigated as a potential long-acting injectable male contraceptive. When testosterone is administered to a man, it functions as a contraceptive by suppressing the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary. Misuse or abuse of testosterone can cause serious side effects such as heart disease (including heart attack), stroke, liver disease, mental/mood problems, abnormal drug-seeking behavior, or . Hormonal male contraception clinical trials began in the 1970s. The method is based on the use of exogenous testosterone alone or in combination with a progestin to suppress the endogenous production of testosterone and spermatogenesis. . In the placebo-controlled randomized clinical trial using injectable testosterone decanoate and . A multicentre study investigating subcutaneous etonogestrel implants with injectable testosterone decanoate as a potential long-acting male contraceptive. Hum Reprod. 2006;21:285-94. . Sjogren B, Gottlieb C. Testosterone for male contraception during one year: attitudes, well-being and quality of sex life. Contraception. 2001;64:59-65.

1. https://aerotenna.readme.io/discuss/659dc6c1b04522002a74c450


2. https://groups.google.com/g/iron-fusion/c/VfFF6ftUkTw


3. https://gamma.app/public/Buy-Serostim-Online-b9c5q91a6zry8bf


4. https://groups.google.com/g/ifbbbro/c/3FdvEg5su0E


5. https://player.soundon.fm/p/a5d3d0d8-04c9-41c4-be90-57ff3defc615

Rate, extent, and modifiers of spermatogenic recovery after hormonal .
An effective hormonal male contraceptive using testosterone . - PubMed
Male Hormonal Contraception: Where Are We Now? - PMC
Drug Insight: recent advances in male hormonal contraception
The use of testosterone as a male contraceptive - PubMed
Investigation of a novel preparation of testosterone decanoate in men .
Testosterone decanoate - Wikipedia
Effective Hormonal Male Contraceptive Using Testosterone Undecanoate .
Male contraception - PMC - National Center for Biotechnology Information
Testosterone Undecanoate Intramuscular: Uses, Side Effects . - WebMD
Multicenter Phase IIb Study of a Novel Combination of Intramuscular .
Male Contraception | SpringerLink
Development of Novel Male Contraceptives - PMC - National Center for .
Testosterone decanoate - Wikiwand
Progress and prospects in male hormonal contraception - PMC
Progress and prospects in male hormonal contraception
Testosterone Undecanoate - an overview | ScienceDirect Topics
Advances in Male Contraception | Endocrine Reviews | Oxford Academic
Testosterone Is a Contraceptive and Should Not Be Used in Men Who .
Male Contraception - PMC - National Center for Biotechnology Information
Investigation of a novel preparation of testosterone decanoate in men .
Male Birth Control Options - Verywell Health
Continuing the search for a hormonal male contraceptive - PMC