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Some supplements have been shown in research to reduce or prevent MDMA-induced neurotoxcity in rodent studies. There are all-in-one products like RaveBox that provide a set of supplements. It seems likely the safer your MDMA dosage, the less important supplements may be. This does not appear to be the case in all users, and anecdotal reports suggest that it may be related to the frequency of use. Alpha-lipoic acid prevents 3,4-methylenedioxy-methamphetamine MDMA -induced neurotoxicity. Acetyl-L-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain. Ascorbic acid prevents 3,4-methylenedioxymethamphetamine MDMA -induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5-HT. Magnesium may help with jaw clenching anecdotal reports. Magnesium is not for neuroprotection, like the other supplements. We are unaware of high quality scientific evidence supporting this. Ginger may help with neuroprotection. Ginger can be ingested via several ways, and the following is an approximate standardization table for 1g of Ginger Extract: Nicotinamide, evidence suggesting MDMA neuroprotection Vitamin E also has a very long elimination half life. Adding green tea catechins i. This recommendation is based on a private conversation we had with a respected drug researcher. We noticed that after we first published the RollSafe guideline on this, avoiding 5-HTP within 24 hours has become the standard recommendation. Downside is the all-in-one kit costs more than buying in bulk and their supplement dosages could be improved, but they are convenient which is a huge plus for many and RaveBox has free shipping worldwide. Every hour, remember the fluid rules: Supplements, afterglows and comedowns Anecdotal evidence only. There is no high quality evidence that 5-HTP is dangerous to combine with MDMA, though there are rumors that this is a bad combination. If you know of good evidence either way, please send it to us. Any trusted brand with mg or less per capsule. Any trusted brand with mg per capsule. Any trusted brand of isotonic fluid Amazon: Propel Electrolyte Powder iHerb: Ultima Powder Packets Recommended dosage and frequency: As a rough guideline: Nature Made Chewable with 50mg sodium mg The sodium in this is an added bonus. Sunkist Chewable mg Within the all-in-one supplement kits Recommended dosage and frequency: Any trusted brand with magnesium glycinate diglycinate , magnesium gluconate, or magnesium citrate. Anecdotal reports suggest that diarrhea is rare with these forms of magnesium, however likely not nonexistent. Magnesium glycinate and gluconate may have the lowest rates of GI-upset, followed by magnesium citrate. Magnesium Gluconate Too expensive to recommend! On the order of 5x more expensive than magnesium glycinate. Mid-range and good absorption: Magnesium Citrate Recommended dosage and frequency: Ginger Ginger may help with neuroprotection. Thanks to Seth for making us aware of this. What if this is too many pills for me? If jaw clenching is an issue for you, add magnesium to the mix too.