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Tapentadol is typically started at a low dose and gradually increased until pain is under control. Dosage should be individualized based on pain severity, therapy response, prior treatment experience and risk factors of addiction, abuse and misuse. Immediate-release tapentadol tablets are typically prescribed with an initial dosage of 50 to 100 mg taken orally every four to six hours as needed for pain relief. Additional doses may be prescribed for the first day of use to achieve optimum pain relief. The maximum dosage for immediate-release tapentadol tablets is 700 mg on the first day and 600 mg on subsequent days. Extended-release tapentadol tablets are typically prescribed with an initial dosage of 50 mg taken twice per day. The maximum dosage of extended-release tapentadol tablets is 500 mg per day.
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The overdose of Tapentadol would lead to some risk factors that include depression, addiction to the drug, and seizures. The toxic effects caused by Tapentadol overdose can be reversed just partially by Naloxone but it might increase the risk of seizures in the patient.
There are many death reports that have been recorded which were caused by the usage of Tapentadol overdose and these are still increasing in Northern Ireland. From the report, the overdose has been mostly caused by the drug interaction of Tapentadol with other drugs that include alcohol too. There are many other deaths that have been recorded within the United States and are mostly in Florida. It is better to take a consultation with a licensed physician before procuring Tapentadol.
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Research that has been conducted on mice has shown some validity in possibly using the drug for treating the symptoms of depression, however, the doctors do not believe that it can be used as an anti-depressant unless it is needed in such cases when the other depression meds that are given have failed.
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