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Claire Zhang (XinRu Zhang) is a Chinese illustrator based in London. She graduated from the School of Visual Arts with a BFA in illustration and the UAL Camberwell University of the Arts in MA illustration. Currently, she is an incoming Fall 2022 student at the Cambridge School of Art studying specifically in Children's books as my second Master degree.
She has her own character's GIF stickers series on Wechat, and her past clients include Penguin Random House, London Design Festival, China Central Television, AAJA New York. Claire has a passion for creating cute animal characters in colourful compositions.
She has worked as a teaching assistant at the Solomon R. Guggenheim Museum, taught the grade 5 students fine art and art history courses at New York P.S.9 Sarah Smith Garnet School.
2014. Kirshkoten Experience by HanMing Zhang.
2022. Tapirulan illustration competition
2021. Hill illustration Competition Finalist.
2020. Society of Illustrators Student Competition Finalist.
2019. Society of Illustrators Student Competition Finalist.
2013. CUC Aniwow! Competition Finalist.
2022. Gallery LVD, ASYAAF 2022, Seoul, Korea
2022. Tapirulan illustrators Contest #17, Cremona, Italy
2021. DIY Art Market at London Design Festival London, UK
2019. Society of Illustrators Student Exhibition, New York, US
2019. Red Envelope Show, Grumpy Bert, Brooklyn, New York, US
2019. Celebration& Pig/Boar, SVA ISO Gallery, New York, US

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This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile. It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community. If you're a ResearchGate member, you can follow this page to keep up with this author's work. If you are this author, and you don't want us to display this page anymore, please let us know .
The cell-to-cell transmission of pathological α-synuclein (α-syn) has been proposed to be a critical event in the development of synucleinopathies. Recent studies have begun to reveal the underlying molecular mechanism of α-syn propagation. As one of the central steps, α-syn secretion is reported to be Ca²⁺-dependent and mediated by unconventional...
α-Synuclein is a central player in Parkinson's disease (PD) pathology. Various point mutations in α-synuclein have been identified to alter the protein-phospholipid binding behavior and cause PD. Therefore, exploration of α-synuclein-phospholipid interaction is important for understanding the PD pathogenesis and helping the early diagnosis of PD. H...
Recent work has revealed that spontaneous release plays critical roles in the central nervous system, but how it is regulated remains elusive. Here we report that synaptotagmin‐11 (Syt11), a Ca2+‐independent Syt isoform associated with schizophrenia and Parkinson’s disease, suppressed spontaneous release. Syt11‐knockout hippocampal neurons showed a...
α-Klotho is known for its aging-related functions and is associated with neurodegenerative diseases, accelerated aging, premature morbidity, and mortality. Recent literature suggests that α-Klotho is also involved in the regulation of mental functions, such as cognition and psychosis. While most of studies of α-Klotho are focusing on its anti-aging...
Synaptotagmin-11 (Syt11) is associated with schizophrenia and Parkinson's disease (PD) and is a critical substrate of parkin, an E3 ubiquitin ligase linked to PD. Previously we reported that Syt11 regulates multiple membrane trafficking pathways in neurons and glia. However, the regulation of Syt11 degradation remains largely unknown. As the ubiqui...
Recent studies suggest that the cell-to-cell spread of pathological α-synuclein (α-syn) plays important roles in the development of Parkinson’s disease (PD). PD patients who carry α-syn gene mutations often have an earlier onset and more severe clinical symptoms and pathology than sporadic PD cases who carry the wild-type (WT) α-syn gene. However,...
Caveolae play crucial roles in intracellular membrane trafficking and mechanosensation. In this study, we report that synaptotagmin-11 (Syt11), a synaptotagmin isoform associated with Parkinson's disease and schizophrenia, regulates both caveolae-mediated endocytosis and the caveolar response to mechanical stimuli in astrocytes. Syt11-knockout (KO)...
Microglia are professional phagocytes in the brain and deficiency in their phagocytic activity plays an important role in Parkinson's disease. This protocol mainly describes the phagocytosis assay for uptake of α-synuclein preformed fibrils, a pathologic form of α-synuclein, by primary microglia.
In chemical synapses, action potentials evoke synaptic vesicle fusion with the presynaptic membrane at the active zone to release neurotransmitter. Synaptic vesicle endocytosis (SVE) then follows exocytosis to recapture vesicle proteins and lipid components for recycling and the maintenance of membrane homeostasis. Therefore, SVE plays an essential...
Cytokine secretion and phagocytosis are key functions of activated microglia. However, the molecular mechanisms underlying their regulation in microglia remain largely unknown. Here, we report that synaptotagmin-11 (Syt11), a non-Ca(2+) -binding Syt implicated in Parkinson disease and schizophrenia, inhibits cytokine secretion and phagocytosis in m...
Precise and efficient endocytosis is essential for vesicle recycling during a sustained neurotransmission. The regulation of endocytosis has been extensively studied, but inhibitors have rarely been found. Here, we show that synaptotagmin-11 (Syt11), a non-Ca(2+)-binding Syt implicated in schizophrenia and Parkinson's disease, inhibits clathrin-med...
... (b) Identifying wild-type and six familial mutant α-synucleins through the deep learning and LC biosensor combination system. Adapted with permission from Ref. [168] . 2021, Wiley. ...
... Concerning the fusion complex, the factor most frequently involved in various tissues and also in cancers (Peng et al., 2021) is the R-SNARE VAMP7 (vesicle-associated protein 7) together with the Q-SNARE SNAP23. Other R-SNAREs, such as VAMP3 and VAMP8, are also effective, however with lower frequency (Verweij et al., 2018; Zhao et al., 2022) . Their ternary complex, established with SNAP23 associated to Syntaxin-4, induces the generation of enlarging pores, called invadopodia, key sites for MVB fusion with the plasma membrane and for the ensuing ILV release (Puri and Roche, 2006;Verweij et al., 2018;Colombo et al., 2021;Peng et al., 2021;Zhao et al., 2022). ...
... These mutants impact aggregation and seeding differently. While substitutions at Alanine 30 and 53 are responsible for early α-synuclein oligomerization [58], non-conserved mutations like H50Q, G51D and A53T have been shown to induce preformed fibril (PFF) dependent seeding in vivo leading to neuroinflammation [59] . As α-synuclein variants, A30P and G51D have exposed hydrophobic NAC domains that cannot bind to membrane lipids resulting in initiation of Lewy aggregates in PD patients; [60,61], molecules that can enhance the association of the NAC domain to the membrane lipids are been actively pursued as attractive therapeutic avenue to prevent α-synuclein aggregation [62]. ...
... Western blotting was performed as described previously [40] . Equal protein amounts of samples were subjected to SDS-PAGE on 12% polyacrylamide gels and then transferred to nitrocellulose membranes. ...
... Not only can HSP90 mediate IL6 signaling pathways in other cell types (Shah et al., 2002;Okawa et al., 2009), IL6-induced pathways can also regulate activation of HSP90 (Stephanou et al., 1998). Two other DEGs suggest promotion of IL6 signaling: SPON1 (upregulated in this study) promotes IL6 mRNA production (Cheng et al., 2009), whereas synaptotagmin 11 (SYT11; downregulated in this study) inhibits IL6 protein secretion (Du et al., 2017) . These findings are likely functionally relevant because IL6 levels were higher in the respective follicular (Rispoli et al., 2019). ...
... Endogenous inhibitors. There are also endogenous peptide inhibitors of CaN, such as Cain/Cabin1, calci pressin, and calsarcins [27, 66,67]. Cain is located in the nucleus of T lymphocytes, where it inhibits activated CaN translocated to the nucleus as a complex with NFAT [29,68]. ...
... As the distribution of large vesicles closing to the plasma membrane in the soma is relatively rare, those cells without large vesicles were excluded for further analysis. No statistical methods were used to predetermine sample sizes but our sample sizes are similar to those reported in previous publications (Lou et al., 2008; Wang et al., 2016) . Electron microscopic data are presented as the mean ± SEM, and statistical significance among various groups was evaluated with two-way ANOVA and Kolmogorov-Smirnov test. ...
Cellular and Molecular Life Sciences (1)
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